Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography
Abstract Pharmacokinetic positron emission tomography (PET) studies rely on the measurement of the arterial input function (AIF), which represents the time-activity curve of the radiotracer concentration in the blood plasma. Traditionally, obtaining the AIF requires invasive procedures, such as arte...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | EJNMMI Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40658-024-00618-2 |
| _version_ | 1797273200769368064 |
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| author | Sara de Scals Luis Mario Fraile José Manuel Udías Laura Martínez Cortés Marta Oteo Miguel Ángel Morcillo José Luis Carreras-Delgado María Nieves Cabrera-Martín Samuel España |
| author_facet | Sara de Scals Luis Mario Fraile José Manuel Udías Laura Martínez Cortés Marta Oteo Miguel Ángel Morcillo José Luis Carreras-Delgado María Nieves Cabrera-Martín Samuel España |
| author_sort | Sara de Scals |
| collection | DOAJ |
| description | Abstract Pharmacokinetic positron emission tomography (PET) studies rely on the measurement of the arterial input function (AIF), which represents the time-activity curve of the radiotracer concentration in the blood plasma. Traditionally, obtaining the AIF requires invasive procedures, such as arterial catheterization, which can be challenging, time-consuming, and associated with potential risks. Therefore, the development of non-invasive techniques for AIF measurement is highly desirable. This study presents a detector for the non-invasive measurement of the AIF in PET studies. The detector is based on the combination of scintillation fibers and silicon photomultipliers (SiPMs) which leads to a very compact and rugged device. The feasibility of the detector was assessed through Monte Carlo simulations conducted on mouse tail and human wrist anatomies studying relevant parameters such as energy spectrum, detector efficiency and minimum detectable activity (MDA). The simulations involved the use of 18F and 68Ga isotopes, which exhibit significantly different positron ranges. In addition, several prototypes were built in order to study the different components of the detector including the scintillation fiber, the coating of the fiber, the SiPMs, and the operating configuration. Finally, the simulations were compared with experimental measurements conducted using a tube filled with both 18F and 68Ga to validate the obtained results. The MDA achieved for both anatomies (approximately 1000 kBq/mL for mice and 1 kBq/mL for humans) falls below the peak radiotracer concentrations typically found in PET studies, affirming the feasibility of conducting non-invasive AIF measurements with the fiber detector. The sensitivity for measurements with a tube filled with 18F (68Ga) was 1.2 (2.07) cps/(kBq/mL), while for simulations, it was 2.81 (6.23) cps/(kBq/mL). Further studies are needed to validate these results in pharmacokinetic PET studies. |
| first_indexed | 2024-03-07T14:40:10Z |
| format | Article |
| id | doaj.art-d2bfe92ec0784a99a5fb0dbd689a713e |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-03-07T14:40:10Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-d2bfe92ec0784a99a5fb0dbd689a713e2024-03-05T20:24:14ZengSpringerOpenEJNMMI Physics2197-73642024-01-0111111710.1186/s40658-024-00618-2Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomographySara de Scals0Luis Mario Fraile1José Manuel Udías2Laura Martínez Cortés3Marta Oteo4Miguel Ángel Morcillo5José Luis Carreras-Delgado6María Nieves Cabrera-Martín7Samuel España8Grupo de Física Nuclear, EMFTEL and IPARCOS, Universidad Complutense de MadridGrupo de Física Nuclear, EMFTEL and IPARCOS, Universidad Complutense de MadridGrupo de Física Nuclear, EMFTEL and IPARCOS, Universidad Complutense de MadridUnidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)Unidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)Unidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)Instituto de Investigación del Hospital Clínico San Carlos (IdISSC)Instituto de Investigación del Hospital Clínico San Carlos (IdISSC)Grupo de Física Nuclear, EMFTEL and IPARCOS, Universidad Complutense de MadridAbstract Pharmacokinetic positron emission tomography (PET) studies rely on the measurement of the arterial input function (AIF), which represents the time-activity curve of the radiotracer concentration in the blood plasma. Traditionally, obtaining the AIF requires invasive procedures, such as arterial catheterization, which can be challenging, time-consuming, and associated with potential risks. Therefore, the development of non-invasive techniques for AIF measurement is highly desirable. This study presents a detector for the non-invasive measurement of the AIF in PET studies. The detector is based on the combination of scintillation fibers and silicon photomultipliers (SiPMs) which leads to a very compact and rugged device. The feasibility of the detector was assessed through Monte Carlo simulations conducted on mouse tail and human wrist anatomies studying relevant parameters such as energy spectrum, detector efficiency and minimum detectable activity (MDA). The simulations involved the use of 18F and 68Ga isotopes, which exhibit significantly different positron ranges. In addition, several prototypes were built in order to study the different components of the detector including the scintillation fiber, the coating of the fiber, the SiPMs, and the operating configuration. Finally, the simulations were compared with experimental measurements conducted using a tube filled with both 18F and 68Ga to validate the obtained results. The MDA achieved for both anatomies (approximately 1000 kBq/mL for mice and 1 kBq/mL for humans) falls below the peak radiotracer concentrations typically found in PET studies, affirming the feasibility of conducting non-invasive AIF measurements with the fiber detector. The sensitivity for measurements with a tube filled with 18F (68Ga) was 1.2 (2.07) cps/(kBq/mL), while for simulations, it was 2.81 (6.23) cps/(kBq/mL). Further studies are needed to validate these results in pharmacokinetic PET studies.https://doi.org/10.1186/s40658-024-00618-2Positron emission tomographyPharmacokinetic studiesArterial input functionScintillation fibers |
| spellingShingle | Sara de Scals Luis Mario Fraile José Manuel Udías Laura Martínez Cortés Marta Oteo Miguel Ángel Morcillo José Luis Carreras-Delgado María Nieves Cabrera-Martín Samuel España Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography EJNMMI Physics Positron emission tomography Pharmacokinetic studies Arterial input function Scintillation fibers |
| title | Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography |
| title_full | Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography |
| title_fullStr | Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography |
| title_full_unstemmed | Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography |
| title_short | Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography |
| title_sort | feasibility study of a sipm fiber detector for non invasive measurement of arterial input function for preclinical and clinical positron emission tomography |
| topic | Positron emission tomography Pharmacokinetic studies Arterial input function Scintillation fibers |
| url | https://doi.org/10.1186/s40658-024-00618-2 |
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