Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight
Abstract Individuals born with very low birth weight (VLBW; < 1500 g) have a higher risk of reduced visual function and brain alterations. In a longitudinal cohort study, we assessed differences in visual outcomes and diffusion metrics from diffusion tensor imaging (DTI) at 3 tesla in the visual...
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| Format: | Article |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52836-4 |
| _version_ | 1797274537801285632 |
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| author | Sigrid Hegna Ingvaldsen Anna Perregaard Jørgensen Arnstein Grøtting Trond Sand Live Eikenes Asta K. Håberg Marit S. Indredavik Stian Lydersen Dordi Austeng Tora Sund Morken Kari Anne I. Evensen |
| author_facet | Sigrid Hegna Ingvaldsen Anna Perregaard Jørgensen Arnstein Grøtting Trond Sand Live Eikenes Asta K. Håberg Marit S. Indredavik Stian Lydersen Dordi Austeng Tora Sund Morken Kari Anne I. Evensen |
| author_sort | Sigrid Hegna Ingvaldsen |
| collection | DOAJ |
| description | Abstract Individuals born with very low birth weight (VLBW; < 1500 g) have a higher risk of reduced visual function and brain alterations. In a longitudinal cohort study, we assessed differences in visual outcomes and diffusion metrics from diffusion tensor imaging (DTI) at 3 tesla in the visual white matter pathway and primary visual cortex at age 26 in VLBW adults versus controls and explored whether DTI metrics at 26 years was associated with visual outcomes at 32 years. Thirty-three VLBW adults and 50 term-born controls was included in the study. Visual outcomes included best corrected visual acuity, contrast sensitivity, P100 latency, and retinal nerve fibre layer thickness. Mean diffusivity, axial diffusivity, radial diffusivity, and fractional anisotropy was extracted from seven regions of interest in the visual pathway: splenium, genu, and body of corpus callosum, optic radiations, lateral geniculate nucleus, inferior-fronto occipital fasciculus, and primary visual cortex. On average the VLBW group had lower contrast sensitivity, a thicker retinal nerve fibre layer and higher axial diffusivity and radial diffusivity in genu of corpus callosum and higher radial diffusivity in optic radiations than the control group. Higher fractional anisotropy in corpus callosum areas were associated with better visual function in the VLBW group but not the control group. |
| first_indexed | 2024-03-07T14:59:49Z |
| format | Article |
| id | doaj.art-d2c3656dba7c4b1bac53bc4fd767989f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T14:59:49Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d2c3656dba7c4b1bac53bc4fd767989f2024-03-05T19:12:39ZengNature PortfolioScientific Reports2045-23222024-02-0114111310.1038/s41598-024-52836-4Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weightSigrid Hegna Ingvaldsen0Anna Perregaard Jørgensen1Arnstein Grøtting2Trond Sand3Live Eikenes4Asta K. Håberg5Marit S. Indredavik6Stian Lydersen7Dordi Austeng8Tora Sund Morken9Kari Anne I. Evensen10Department of Neuromedicine and Movement Science, NTNU Norwegian University of Science and TechnologyDepartment of Neuromedicine and Movement Science, NTNU Norwegian University of Science and TechnologyDepartment of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim University HospitalDepartment of Neuromedicine and Movement Science, NTNU Norwegian University of Science and TechnologyDepartment of Radiology and Nuclear Medicine, MR-Center, Trondheim University HospitalDepartment of Neuromedicine and Movement Science, NTNU Norwegian University of Science and TechnologyDepartment of Clinical and Molecular Medicine, Norwegian University of Science and TechnologyRegional Centre for Child and Youth Mental Health and Child Welfare, Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Neuromedicine and Movement Science, NTNU Norwegian University of Science and TechnologyDepartment of Neuromedicine and Movement Science, NTNU Norwegian University of Science and TechnologyDepartment of Clinical and Molecular Medicine, Norwegian University of Science and TechnologyAbstract Individuals born with very low birth weight (VLBW; < 1500 g) have a higher risk of reduced visual function and brain alterations. In a longitudinal cohort study, we assessed differences in visual outcomes and diffusion metrics from diffusion tensor imaging (DTI) at 3 tesla in the visual white matter pathway and primary visual cortex at age 26 in VLBW adults versus controls and explored whether DTI metrics at 26 years was associated with visual outcomes at 32 years. Thirty-three VLBW adults and 50 term-born controls was included in the study. Visual outcomes included best corrected visual acuity, contrast sensitivity, P100 latency, and retinal nerve fibre layer thickness. Mean diffusivity, axial diffusivity, radial diffusivity, and fractional anisotropy was extracted from seven regions of interest in the visual pathway: splenium, genu, and body of corpus callosum, optic radiations, lateral geniculate nucleus, inferior-fronto occipital fasciculus, and primary visual cortex. On average the VLBW group had lower contrast sensitivity, a thicker retinal nerve fibre layer and higher axial diffusivity and radial diffusivity in genu of corpus callosum and higher radial diffusivity in optic radiations than the control group. Higher fractional anisotropy in corpus callosum areas were associated with better visual function in the VLBW group but not the control group.https://doi.org/10.1038/s41598-024-52836-4 |
| spellingShingle | Sigrid Hegna Ingvaldsen Anna Perregaard Jørgensen Arnstein Grøtting Trond Sand Live Eikenes Asta K. Håberg Marit S. Indredavik Stian Lydersen Dordi Austeng Tora Sund Morken Kari Anne I. Evensen Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight Scientific Reports |
| title | Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight |
| title_full | Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight |
| title_fullStr | Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight |
| title_full_unstemmed | Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight |
| title_short | Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight |
| title_sort | visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight |
| url | https://doi.org/10.1038/s41598-024-52836-4 |
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