Novel Radioiodinated and Radiofluorinated Analogues of FT-2102 for SPECT or PET Imaging of mIDH1 Mutant Tumours

Novel Radioiodinated and Radiofluorinated Analogues of FT-2102 for SPECT or PET Imaging of mIDH1 Mutant Tumours

Isocitrate dehydrogenases (IDHs) are metabolic enzymes commonly mutated in human cancers (glioma, acute myeloid leukaemia, chondrosarcoma, and intrahepatic cholangiocarcinoma). These mutated variants of IDH (mIDH) acquire a neomorphic activity, namely, conversion of α-ketoglutarate to the oncometabo...

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Bibliographic Details
Main Authors: Valérie Weber, Lucie Arnaud, Sladjana Dukic-Stefanovic, Barbara Wenzel, Valérie Roux, Jean-Michel Chezal, Thu-Hang Lai, Rodrigo Teodoro, Klaus Kopka, Elisabeth Miot-Noirault, Winnie Deuther-Conrad, Aurélie Maisonial-Besset
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
SPECT/PET imaging
mIDH1
FT-2102
radioiodination
radiofluorination
Online Access:https://www.mdpi.com/1420-3049/27/12/3766

Internet

https://www.mdpi.com/1420-3049/27/12/3766

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