The clinical utility of gene testing for Alzheimer’s disease
Alzheimer’s disease (AD) is the largest cause of dementia, affecting 35.6 million people in 2010. Amyloid precursor protein, presenilin 1 and presenilin 2 mutations are known to cause familial early-onset AD, whereas apolipoprotein E (APOE) ε4 is a susceptibility gene for late-onset AD. The genes fo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-04-01
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| Series: | Neurology International |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/ni/article/view/2140 |
| _version_ | 1827885701400625152 |
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| author | Emily R. Atkins Peter K. Panegyres |
| author_facet | Emily R. Atkins Peter K. Panegyres |
| author_sort | Emily R. Atkins |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the largest cause of dementia, affecting 35.6 million people in 2010. Amyloid precursor protein, presenilin 1 and presenilin 2 mutations are known to cause familial early-onset AD, whereas apolipoprotein E (APOE) ε4 is a susceptibility gene for late-onset AD. The genes for phosphatidylinositol- binding clathrin assembly protein, clusterin and complement receptor 1 have recently been described by genome-wide association studies as potential risk factors for lateonset AD. Also, a genome association study using single neucleotide polymorphisms has identified an association of neuronal sortilin related receptor and late-onset AD. Gene testing, and also predictive gene testing, may be of benefit in suspected familial early-onset AD however it adds little to the diagnosis of lateonset AD and does not alter the treatment. We do not recommend APOE ε4 genotyping. |
| first_indexed | 2024-03-12T19:50:27Z |
| format | Article |
| id | doaj.art-d2c626a02bc9435a8811225a8609eb43 |
| institution | Directory Open Access Journal |
| issn | 2035-8385 2035-8377 |
| language | English |
| last_indexed | 2024-03-12T19:50:27Z |
| publishDate | 2011-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-d2c626a02bc9435a8811225a8609eb432023-08-02T03:15:23ZengMDPI AGNeurology International2035-83852035-83772011-04-0131e1e110.4081/ni.2011.e11432The clinical utility of gene testing for Alzheimer’s diseaseEmily R. Atkins0Peter K. Panegyres1Neurodegenerative Disorders Research Pty LtdNeurodegenerative Disorders Research Pty LtdAlzheimer’s disease (AD) is the largest cause of dementia, affecting 35.6 million people in 2010. Amyloid precursor protein, presenilin 1 and presenilin 2 mutations are known to cause familial early-onset AD, whereas apolipoprotein E (APOE) ε4 is a susceptibility gene for late-onset AD. The genes for phosphatidylinositol- binding clathrin assembly protein, clusterin and complement receptor 1 have recently been described by genome-wide association studies as potential risk factors for lateonset AD. Also, a genome association study using single neucleotide polymorphisms has identified an association of neuronal sortilin related receptor and late-onset AD. Gene testing, and also predictive gene testing, may be of benefit in suspected familial early-onset AD however it adds little to the diagnosis of lateonset AD and does not alter the treatment. We do not recommend APOE ε4 genotyping.http://www.pagepress.org/journals/index.php/ni/article/view/2140Neurology, Alzheimer's disease, gene testing |
| spellingShingle | Emily R. Atkins Peter K. Panegyres The clinical utility of gene testing for Alzheimer’s disease Neurology International Neurology, Alzheimer's disease, gene testing |
| title | The clinical utility of gene testing for Alzheimer’s disease |
| title_full | The clinical utility of gene testing for Alzheimer’s disease |
| title_fullStr | The clinical utility of gene testing for Alzheimer’s disease |
| title_full_unstemmed | The clinical utility of gene testing for Alzheimer’s disease |
| title_short | The clinical utility of gene testing for Alzheimer’s disease |
| title_sort | clinical utility of gene testing for alzheimer s disease |
| topic | Neurology, Alzheimer's disease, gene testing |
| url | http://www.pagepress.org/journals/index.php/ni/article/view/2140 |
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