Effect of the Lavender, sesame oil, combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice
Background and Objective: Burn is one of the leading causes of mortality in the world. This study was done to determine the effect of the lavender, sesame oil, and combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice. Methods: In this experimental study,...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Golestan University of Medical Sciences
2018-03-01
|
| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-1027&slc_lang=en&sid=1 |
| _version_ | 1818937993252044800 |
|---|---|
| author | Aria Afshari Mahdieh Raeeszadeh Loghman Akradi |
| author_facet | Aria Afshari Mahdieh Raeeszadeh Loghman Akradi |
| author_sort | Aria Afshari |
| collection | DOAJ |
| description | Background and Objective: Burn is one of the leading causes of mortality in the world. This study was done to determine the effect of the lavender, sesame oil, and combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice.
Methods: In this experimental study, 30 male adult albino mice were randomly allocated into 5 groups as follows: the negative control group (physiology serum); the positive control group (silver sulfadiazine); the first experimental group (sesame oil), the second experimental group (combination of Lavender with sesame oil) and the third experimental group (Lavender oil).Second degree of burn wound healing take place using hot sheet with a diameter of 2 cm. wound treatment was done in five groups in 21-day treatment period. The wound diameter size and restoration percentage were measured on days 1, 3, 6, 9, 18, and 21. Some mice were euthanized and the samples of wounds were used for histopathological studies.
Results: The percentage of wound healing significantly increased in groups of silver sulfadiazine, combination of Lavender with sesame oil, Lavender oil and sesame oil in compared to control group (P<0.05). The improvement percentage was seen in sulfadiazine and combination of Lavender with sesame oil groups in compared to negative control group. The level of tissue restoration based on the accumulation of collagen, fibroblasts, re-epithelialization were seen in sulfadiazine, combination of Lavender with sesame oil, Lavender oil and sesame oil, respectively.
Conclusion: Combination of Lavender with sesame oil similar to silver sulfadiazine has tissue restoration effect on burn wound healing in animal model. |
| first_indexed | 2024-12-20T06:00:47Z |
| format | Article |
| id | doaj.art-d2c62cc9874e4f43845fc2ac98ef0c7a |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-20T06:00:47Z |
| publishDate | 2018-03-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-d2c62cc9874e4f43845fc2ac98ef0c7a2022-12-21T19:50:55ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802018-03-012015157Effect of the Lavender, sesame oil, combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in miceAria Afshari0Mahdieh Raeeszadeh1Loghman Akradi2 Graduate of Doctor of Veterirary Medicine, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran Assistant Professor, Department of Basic Sciences, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran. vet_mr@yahoo.com Assistant Professor, Department of Pathobiology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran Background and Objective: Burn is one of the leading causes of mortality in the world. This study was done to determine the effect of the lavender, sesame oil, and combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice. Methods: In this experimental study, 30 male adult albino mice were randomly allocated into 5 groups as follows: the negative control group (physiology serum); the positive control group (silver sulfadiazine); the first experimental group (sesame oil), the second experimental group (combination of Lavender with sesame oil) and the third experimental group (Lavender oil).Second degree of burn wound healing take place using hot sheet with a diameter of 2 cm. wound treatment was done in five groups in 21-day treatment period. The wound diameter size and restoration percentage were measured on days 1, 3, 6, 9, 18, and 21. Some mice were euthanized and the samples of wounds were used for histopathological studies. Results: The percentage of wound healing significantly increased in groups of silver sulfadiazine, combination of Lavender with sesame oil, Lavender oil and sesame oil in compared to control group (P<0.05). The improvement percentage was seen in sulfadiazine and combination of Lavender with sesame oil groups in compared to negative control group. The level of tissue restoration based on the accumulation of collagen, fibroblasts, re-epithelialization were seen in sulfadiazine, combination of Lavender with sesame oil, Lavender oil and sesame oil, respectively. Conclusion: Combination of Lavender with sesame oil similar to silver sulfadiazine has tissue restoration effect on burn wound healing in animal model.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-1027&slc_lang=en&sid=1Burn woundWound healingLavender oilSesame oilSilver sulfadiazineMice |
| spellingShingle | Aria Afshari Mahdieh Raeeszadeh Loghman Akradi Effect of the Lavender, sesame oil, combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice مجله دانشگاه علوم پزشکی گرگان Burn wound Wound healing Lavender oil Sesame oil Silver sulfadiazine Mice |
| title | Effect of the Lavender, sesame oil, combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice |
| title_full | Effect of the Lavender, sesame oil, combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice |
| title_fullStr | Effect of the Lavender, sesame oil, combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice |
| title_full_unstemmed | Effect of the Lavender, sesame oil, combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice |
| title_short | Effect of the Lavender, sesame oil, combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice |
| title_sort | effect of the lavender sesame oil combination of lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice |
| topic | Burn wound Wound healing Lavender oil Sesame oil Silver sulfadiazine Mice |
| url | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-1027&slc_lang=en&sid=1 |
| work_keys_str_mv | AT ariaafshari effectofthelavendersesameoilcombinationoflavenderwithsesameoilandsilversulfadiazineontheburnwoundhealinginmice AT mahdiehraeeszadeh effectofthelavendersesameoilcombinationoflavenderwithsesameoilandsilversulfadiazineontheburnwoundhealinginmice AT loghmanakradi effectofthelavendersesameoilcombinationoflavenderwithsesameoilandsilversulfadiazineontheburnwoundhealinginmice |