Clonal evolution driven by superdriver mutations

Clonal evolution driven by superdriver mutations

Abstract Background Tumors are widely recognized to progress through clonal evolution by sequentially acquiring selectively advantageous genetic alterations that significantly contribute to tumorigenesis and thus are termned drivers. Some cancer drivers, such as TP53 point mutation or EGFR copy numb...

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Bibliographic Details
Main Authors: Patrick Grossmann, Simona Cristea, Niko Beerenwinkel
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Evolutionary Biology
Subjects:
Cancer progression
Tumorigenesis
Mutation
Selection
Fitness
Waiting time to cancer
Online Access:http://link.springer.com/article/10.1186/s12862-020-01647-y

Internet

http://link.springer.com/article/10.1186/s12862-020-01647-y

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