CIDE Proteins in Human Health and Disease
Cell death-Inducing DNA Fragmentation Factor Alpha (DFFA)-like Effector (CIDE) proteins have emerged as lipid droplet-associated proteins that regulate fat metabolism. There are three members in the CIDE protein family—CIDEA, CIDEB, and CIDEC (also known as fat-specific protein 27 (FSP27))...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/8/3/238 |
| _version_ | 1797719881410412544 |
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| author | Mark Slayton Abhishek Gupta Bijinu Balakrishnan Vishwajeet Puri |
| author_facet | Mark Slayton Abhishek Gupta Bijinu Balakrishnan Vishwajeet Puri |
| author_sort | Mark Slayton |
| collection | DOAJ |
| description | Cell death-Inducing DNA Fragmentation Factor Alpha (DFFA)-like Effector (CIDE) proteins have emerged as lipid droplet-associated proteins that regulate fat metabolism. There are three members in the CIDE protein family—CIDEA, CIDEB, and CIDEC (also known as fat-specific protein 27 (FSP27)). CIDEA and FSP27 are primarily expressed in adipose tissue, while CIDEB is expressed in the liver. Originally, based upon their homology with DNA fragmentation factors, these proteins were identified as apoptotic proteins. However, recent studies have changed the perception of these proteins, redefining them as regulators of lipid droplet dynamics and fat metabolism, which contribute to a healthy metabolic phenotype in humans. Despite various studies in humans and gene-targeting studies in mice, the physiological roles of CIDE proteins remains elusive. This review will summarize the known physiological role and metabolic pathways regulated by the CIDE proteins in human health and disease. |
| first_indexed | 2024-03-12T09:11:15Z |
| format | Article |
| id | doaj.art-d2c8c9b161834739ae266ed5eb9b3c51 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T09:11:15Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d2c8c9b161834739ae266ed5eb9b3c512023-09-02T15:01:24ZengMDPI AGCells2073-44092019-03-018323810.3390/cells8030238cells8030238CIDE Proteins in Human Health and DiseaseMark Slayton0Abhishek Gupta1Bijinu Balakrishnan2Vishwajeet Puri3Department of Biomedical Sciences and Diabetes Institute, Ohio University Heritage College of Osteopathic Medicine, Athens, OH 45701, USADepartment of Biomedical Sciences and Diabetes Institute, Ohio University Heritage College of Osteopathic Medicine, Athens, OH 45701, USADepartment of Biomedical Sciences and Diabetes Institute, Ohio University Heritage College of Osteopathic Medicine, Athens, OH 45701, USADepartment of Biomedical Sciences and Diabetes Institute, Ohio University Heritage College of Osteopathic Medicine, Athens, OH 45701, USACell death-Inducing DNA Fragmentation Factor Alpha (DFFA)-like Effector (CIDE) proteins have emerged as lipid droplet-associated proteins that regulate fat metabolism. There are three members in the CIDE protein family—CIDEA, CIDEB, and CIDEC (also known as fat-specific protein 27 (FSP27)). CIDEA and FSP27 are primarily expressed in adipose tissue, while CIDEB is expressed in the liver. Originally, based upon their homology with DNA fragmentation factors, these proteins were identified as apoptotic proteins. However, recent studies have changed the perception of these proteins, redefining them as regulators of lipid droplet dynamics and fat metabolism, which contribute to a healthy metabolic phenotype in humans. Despite various studies in humans and gene-targeting studies in mice, the physiological roles of CIDE proteins remains elusive. This review will summarize the known physiological role and metabolic pathways regulated by the CIDE proteins in human health and disease.http://www.mdpi.com/2073-4409/8/3/238CIDEACIDEBFSP27fat metabolismlipid dropletsadiposeliver |
| spellingShingle | Mark Slayton Abhishek Gupta Bijinu Balakrishnan Vishwajeet Puri CIDE Proteins in Human Health and Disease Cells CIDEA CIDEB FSP27 fat metabolism lipid droplets adipose liver |
| title | CIDE Proteins in Human Health and Disease |
| title_full | CIDE Proteins in Human Health and Disease |
| title_fullStr | CIDE Proteins in Human Health and Disease |
| title_full_unstemmed | CIDE Proteins in Human Health and Disease |
| title_short | CIDE Proteins in Human Health and Disease |
| title_sort | cide proteins in human health and disease |
| topic | CIDEA CIDEB FSP27 fat metabolism lipid droplets adipose liver |
| url | http://www.mdpi.com/2073-4409/8/3/238 |
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