YAP/Smad3 promotes pathological extracellular matrix microenviroment‐induced bladder smooth muscle proliferation in bladder fibrosis progression

YAP/Smad3 promotes pathological extracellular matrix microenviroment‐induced bladder smooth muscle proliferation in bladder fibrosis progression

Abstract Fibrosis is a chronic inflammation process with excess extracellular matrix (ECM) deposition that cannot be reversed. Patients suffer from bladder dysfunction caused by bladder fibrosis. Moreover, the interactive mechanisms between ECM and bladder fibrosis are still obscure. Hence, we asses...

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Bibliographic Details
Main Authors: Xing‐Peng Di, Xi Jin, Jian‐Zhong Ai, Li‐Yuan Xiang, Xiao‐Shuai Gao, Kai‐Wen Xiao, Hong Li, De‐Yi Luo, Kun‐Jie Wang
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:MedComm
Subjects:
bladder fibrosis
extracellular matrix stiffness
proliferation
Smad3
YAP
Online Access:https://doi.org/10.1002/mco2.169

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