Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery
The aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to preoperative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the postoperative level of pain, use of analgesics, inflammation, and oxidative stress. The study enroll...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-12-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2023-0040 |
| _version_ | 1797349325349584896 |
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| author | Peršec Jasminka Šribar Andrej Ilić Monika Mamić Ivan Kifer Domagoj Domijan Ana-Marija Maleš Željan Turčić Petra |
| author_facet | Peršec Jasminka Šribar Andrej Ilić Monika Mamić Ivan Kifer Domagoj Domijan Ana-Marija Maleš Željan Turčić Petra |
| author_sort | Peršec Jasminka |
| collection | DOAJ |
| description | The aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to preoperative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the postoperative level of pain, use of analgesics, inflammation, and oxidative stress. The study enrolled 42 patients who underwent elective thoracic surgery in a one-year period at the University Hospital Dubrava (Zagreb, Croatia). Based on a computer-generated randomization list the patients were assigned to the dexmedetomidine (n = 18) or dexamethasone (n = 24) group. Postoperatively, patients of dexmedetomidine group reported lower pain (VAS value 1 h post surgery, 3.4 ± 2.7 vs. 5.4 ± 1.8, dexmedetomidine vs. dexamethasone, p < 0.01) and had lower anal-gesic requirements in comparison with dexamethasone group. Thus, dexmedetomidine in comparison with dexamethasone was more efficient in lowering pain and analgesia requirements 24 h after the surgery. On the contrary, dexamethasone had better anti-inflammatory properties (CRP level 24 h post surgery, 131.9 ± 90.7 vs. 26.0 ± 55.2 mg L−1, dexmedetomidine vs. dexamethasone, p < 0.01). Both dexmedetomidine and dexamethasone exhibited antioxidant effects, however, their antioxidant properties should be further explored. The results of this study improve current knowledge of pain control in thoracic surgery. |
| first_indexed | 2024-03-08T12:28:44Z |
| format | Article |
| id | doaj.art-d2ca68fc3dce4bb1b927569966b67994 |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2024-03-08T12:28:44Z |
| publishDate | 2023-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-d2ca68fc3dce4bb1b927569966b679942024-01-22T07:05:24ZengSciendoActa Pharmaceutica1846-95582023-12-0173469170810.2478/acph-2023-0040Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgeryPeršec Jasminka0Šribar Andrej1Ilić Monika2Mamić Ivan3Kifer Domagoj4Domijan Ana-Marija5Maleš Željan6Turčić Petra71Clinical Department for Anesthesiology Reanimatology and Intensive Care Medicine, University Hospital DubravaZagreb, Croatia1Clinical Department for Anesthesiology Reanimatology and Intensive Care Medicine, University Hospital DubravaZagreb, Croatia1Clinical Department for Anesthesiology Reanimatology and Intensive Care Medicine, University Hospital DubravaZagreb, Croatia3University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmacology, Zagreb, Croatia4University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Biophysics, Zagreb, Croatia5University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Botany, Zagreb, Croatia5University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Botany, Zagreb, Croatia3University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmacology, Zagreb, CroatiaThe aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to preoperative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the postoperative level of pain, use of analgesics, inflammation, and oxidative stress. The study enrolled 42 patients who underwent elective thoracic surgery in a one-year period at the University Hospital Dubrava (Zagreb, Croatia). Based on a computer-generated randomization list the patients were assigned to the dexmedetomidine (n = 18) or dexamethasone (n = 24) group. Postoperatively, patients of dexmedetomidine group reported lower pain (VAS value 1 h post surgery, 3.4 ± 2.7 vs. 5.4 ± 1.8, dexmedetomidine vs. dexamethasone, p < 0.01) and had lower anal-gesic requirements in comparison with dexamethasone group. Thus, dexmedetomidine in comparison with dexamethasone was more efficient in lowering pain and analgesia requirements 24 h after the surgery. On the contrary, dexamethasone had better anti-inflammatory properties (CRP level 24 h post surgery, 131.9 ± 90.7 vs. 26.0 ± 55.2 mg L−1, dexmedetomidine vs. dexamethasone, p < 0.01). Both dexmedetomidine and dexamethasone exhibited antioxidant effects, however, their antioxidant properties should be further explored. The results of this study improve current knowledge of pain control in thoracic surgery.https://doi.org/10.2478/acph-2023-0040dexmedetomidinedexamethasonethoracotomylocal anestheticanalgesic efficacy |
| spellingShingle | Peršec Jasminka Šribar Andrej Ilić Monika Mamić Ivan Kifer Domagoj Domijan Ana-Marija Maleš Željan Turčić Petra Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery Acta Pharmaceutica dexmedetomidine dexamethasone thoracotomy local anesthetic analgesic efficacy |
| title | Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery |
| title_full | Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery |
| title_fullStr | Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery |
| title_full_unstemmed | Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery |
| title_short | Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery |
| title_sort | effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain analgesic requirements inflammation and oxidative stress in thoracic surgery |
| topic | dexmedetomidine dexamethasone thoracotomy local anesthetic analgesic efficacy |
| url | https://doi.org/10.2478/acph-2023-0040 |
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