Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID‐19
Abstract Background COVID‐19 has a broad clinical spectrum. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity. Methods Clinical and laboratory data from 610 COVID‐19 cases hospital...
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| Format: | Article |
| Language: | English |
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Wiley
2021-04-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.215 |
| _version_ | 1819073429660237824 |
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| author | Huadong Yan Amrita Vijay Fanrong Jiang Nanhong Zheng Yaoren Hu Honghua Ye Benjamin Ollivere Ting Cai Ana M Valdes Guruprasad P. Aithal |
| author_facet | Huadong Yan Amrita Vijay Fanrong Jiang Nanhong Zheng Yaoren Hu Honghua Ye Benjamin Ollivere Ting Cai Ana M Valdes Guruprasad P. Aithal |
| author_sort | Huadong Yan |
| collection | DOAJ |
| description | Abstract Background COVID‐19 has a broad clinical spectrum. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity. Methods Clinical and laboratory data from 610 COVID‐19 cases hospitalized in the province of Zheijang, China were investigated as risk factors for severe COVID‐19 (assessed by respiratory distress) compared to mild or common forms using logistic regression methods. Biochemical markers were correlated with severity using spearman correlations, and a ROC analysis was used to determine the individual contribution of each of the biochemical markers on severity. We carried out formal mediation analyses to investigate the extent of the effect of body mass index (BMI) on COVID‐19 severity mediated by hypertension, glycemia, Lactose Dehydrogenase (LDH) at the time of hospitalization and C‐Reactive Protein levels (CRP), in units of standard deviations. Results The individual markers measured on admission contributing most strongly to prediction of COVID‐19 severity as assessed at discharge were LDH, CRP and glucose. The proportion of the effect of BMI on severity of COVID‐19 mediated by CRP, glycemia or hypertension, we find that glucose mediated 79% (p < .0001), LDH mediated 78% (p < .0001), hypertension mediated 66% (p < .0001); however, only 44% (p < .005) was mediated by systemic inflammation (CRP). Conclusion Our data indicate that a larger proportion of the effect of BMI on severity of COVID‐19 is mediated by glycemia and LDH levels whereas less than half of it is mediated by systemic inflammation. |
| first_indexed | 2024-12-21T17:53:29Z |
| format | Article |
| id | doaj.art-d2caec6ecbf446c7acd26146513f62e3 |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-12-21T17:53:29Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-d2caec6ecbf446c7acd26146513f62e32022-12-21T18:55:17ZengWileyEndocrinology, Diabetes & Metabolism2398-92382021-04-0142n/an/a10.1002/edm2.215Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID‐19Huadong Yan0Amrita Vijay1Fanrong Jiang2Nanhong Zheng3Yaoren Hu4Honghua Ye5Benjamin Ollivere6Ting Cai7Ana M Valdes8Guruprasad P. Aithal9Department of Infectious Diseases Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Hwamei Hospital University of Chinese Academy of Sciences Ningbo ChinaNIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UKNingbo Institute of Life and Health Industry University of Chinese Academy of Sciences Ningbo ChinaDepartment of Infectious Diseases Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Hwamei Hospital University of Chinese Academy of Sciences Ningbo ChinaDepartment of Infectious Diseases Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Hwamei Hospital University of Chinese Academy of Sciences Ningbo ChinaNingbo Institute of Life and Health Industry University of Chinese Academy of Sciences Ningbo ChinaNIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UKDepartment of Infectious Diseases Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Hwamei Hospital University of Chinese Academy of Sciences Ningbo ChinaNIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UKNIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UKAbstract Background COVID‐19 has a broad clinical spectrum. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity. Methods Clinical and laboratory data from 610 COVID‐19 cases hospitalized in the province of Zheijang, China were investigated as risk factors for severe COVID‐19 (assessed by respiratory distress) compared to mild or common forms using logistic regression methods. Biochemical markers were correlated with severity using spearman correlations, and a ROC analysis was used to determine the individual contribution of each of the biochemical markers on severity. We carried out formal mediation analyses to investigate the extent of the effect of body mass index (BMI) on COVID‐19 severity mediated by hypertension, glycemia, Lactose Dehydrogenase (LDH) at the time of hospitalization and C‐Reactive Protein levels (CRP), in units of standard deviations. Results The individual markers measured on admission contributing most strongly to prediction of COVID‐19 severity as assessed at discharge were LDH, CRP and glucose. The proportion of the effect of BMI on severity of COVID‐19 mediated by CRP, glycemia or hypertension, we find that glucose mediated 79% (p < .0001), LDH mediated 78% (p < .0001), hypertension mediated 66% (p < .0001); however, only 44% (p < .005) was mediated by systemic inflammation (CRP). Conclusion Our data indicate that a larger proportion of the effect of BMI on severity of COVID‐19 is mediated by glycemia and LDH levels whereas less than half of it is mediated by systemic inflammation.https://doi.org/10.1002/edm2.215biochemical markersBMICOVID‐19disease severity |
| spellingShingle | Huadong Yan Amrita Vijay Fanrong Jiang Nanhong Zheng Yaoren Hu Honghua Ye Benjamin Ollivere Ting Cai Ana M Valdes Guruprasad P. Aithal Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID‐19 Endocrinology, Diabetes & Metabolism biochemical markers BMI COVID‐19 disease severity |
| title | Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID‐19 |
| title_full | Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID‐19 |
| title_fullStr | Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID‐19 |
| title_full_unstemmed | Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID‐19 |
| title_short | Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID‐19 |
| title_sort | serum glucose lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of covid 19 |
| topic | biochemical markers BMI COVID‐19 disease severity |
| url | https://doi.org/10.1002/edm2.215 |
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