Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements
Purpose: The impact of cataract surgery on low luminance visual acuity deficit (LLVAD) measurements was investigated by measuring the LLVAD before and after cataract surgery. Design: Prospective, longitudinal study. Participants: Patients undergoing cataract surgery. Methods: Photopic luminance (PL)...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Ophthalmology Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914522000598 |
| _version_ | 1818016331117625344 |
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| author | Mengxi Shen, MD Yingying Shi, MD Liang Wang, BS Jonathan F. Russell, MD, PhD Xiaoshuang Jiang, MD, PhD Rita Laiginhas, MD, PhD Prashanth Iyer, MD, MPH Omer Trivizki, MD Marie Thulliez, MD Sonia H. Yoo, MD Terri P. Rose, OD, FAAO Ranya G. Habash, MD Guillermo Amescua, MD William J. Feuer, MS Giovanni Gregori, PhD Philip J. Rosenfeld, MD, PhD |
| author_facet | Mengxi Shen, MD Yingying Shi, MD Liang Wang, BS Jonathan F. Russell, MD, PhD Xiaoshuang Jiang, MD, PhD Rita Laiginhas, MD, PhD Prashanth Iyer, MD, MPH Omer Trivizki, MD Marie Thulliez, MD Sonia H. Yoo, MD Terri P. Rose, OD, FAAO Ranya G. Habash, MD Guillermo Amescua, MD William J. Feuer, MS Giovanni Gregori, PhD Philip J. Rosenfeld, MD, PhD |
| author_sort | Mengxi Shen, MD |
| collection | DOAJ |
| description | Purpose: The impact of cataract surgery on low luminance visual acuity deficit (LLVAD) measurements was investigated by measuring the LLVAD before and after cataract surgery. Design: Prospective, longitudinal study. Participants: Patients undergoing cataract surgery. Methods: Photopic luminance (PL)–best-corrected visual acuity (BCVA) and low luminance (LL)–BCVA were obtained using the ETDRS chart. Low luminance visual acuity deficit scores were calculated by subtracting the LL-BCVA letter score from the PL-BCVA letter score. To demonstrate the reproducibility of these visual acuity measurements, we used data from drusen-only eyes previously published in the Complement Inhibition with Eculizumab for the Treatment of Nonexudative Age-Related Macular Degeneration (COMPLETE) study. The PL-BCVA, LL-BCVA, and LLVAD measurements obtained at an interval of 3 months in this cohort were used for comparison. In the current study, the impact of cataract surgery on LLVAD measurements was analyzed by comparing the PL-BCVA, LL-BCVA, and LLVAD measurements before and after cataract surgery. Main Outcome Measures: The reproducibility of the visual acuity measurements and the changes in LLVAD measurement after cataract surgery. Results: In the COMPLETE study, no clinically significant differences were found in the PL-BCVA, LL-BCVA, or LLVAD measurements between baseline and the 3-month follow-up visits with a change of –1.1 letters, –1.3 letters, and 0.1 letters, respectively (P = 0.02, P = 0.11, and P = 0.88, respectively). In the current study, significant increases were found in the PL-BCVA and LL-BCVA measurements, with a change of 7.3 letters and 10.2 letters after cataract surgery (P < 0.001 for both), and a statistically significant decrease in LLVAD measurements was found, with a change of –3.0 letters after cataract surgery (P = 0.002). Conclusions: Because of the variable effect of cataracts on LL-BCVA measurements and the significant change in LLVAD measurements after cataract surgery, investigators should be aware that cataract surgery during a trial will have an unpredictable impact on LLVAD measurements, and pseudophakic and phakic patients should be analyzed separately. |
| first_indexed | 2024-04-14T07:10:50Z |
| format | Article |
| id | doaj.art-d2cceb1a921144dda6f8778f3f4fcdcb |
| institution | Directory Open Access Journal |
| issn | 2666-9145 |
| language | English |
| last_indexed | 2024-04-14T07:10:50Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ophthalmology Science |
| spelling | doaj.art-d2cceb1a921144dda6f8778f3f4fcdcb2022-12-22T02:06:26ZengElsevierOphthalmology Science2666-91452022-09-0123100170Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit MeasurementsMengxi Shen, MD0Yingying Shi, MD1Liang Wang, BS2Jonathan F. Russell, MD, PhD3Xiaoshuang Jiang, MD, PhD4Rita Laiginhas, MD, PhD5Prashanth Iyer, MD, MPH6Omer Trivizki, MD7Marie Thulliez, MD8Sonia H. Yoo, MD9Terri P. Rose, OD, FAAO10Ranya G. Habash, MD11Guillermo Amescua, MD12William J. Feuer, MS13Giovanni Gregori, PhD14Philip J. Rosenfeld, MD, PhD15Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaInstitute for Vision Research and Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IowaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Correspondence: Philip J. Rosenfeld, MD, PhD, Department of Ophthalmology, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136.Purpose: The impact of cataract surgery on low luminance visual acuity deficit (LLVAD) measurements was investigated by measuring the LLVAD before and after cataract surgery. Design: Prospective, longitudinal study. Participants: Patients undergoing cataract surgery. Methods: Photopic luminance (PL)–best-corrected visual acuity (BCVA) and low luminance (LL)–BCVA were obtained using the ETDRS chart. Low luminance visual acuity deficit scores were calculated by subtracting the LL-BCVA letter score from the PL-BCVA letter score. To demonstrate the reproducibility of these visual acuity measurements, we used data from drusen-only eyes previously published in the Complement Inhibition with Eculizumab for the Treatment of Nonexudative Age-Related Macular Degeneration (COMPLETE) study. The PL-BCVA, LL-BCVA, and LLVAD measurements obtained at an interval of 3 months in this cohort were used for comparison. In the current study, the impact of cataract surgery on LLVAD measurements was analyzed by comparing the PL-BCVA, LL-BCVA, and LLVAD measurements before and after cataract surgery. Main Outcome Measures: The reproducibility of the visual acuity measurements and the changes in LLVAD measurement after cataract surgery. Results: In the COMPLETE study, no clinically significant differences were found in the PL-BCVA, LL-BCVA, or LLVAD measurements between baseline and the 3-month follow-up visits with a change of –1.1 letters, –1.3 letters, and 0.1 letters, respectively (P = 0.02, P = 0.11, and P = 0.88, respectively). In the current study, significant increases were found in the PL-BCVA and LL-BCVA measurements, with a change of 7.3 letters and 10.2 letters after cataract surgery (P < 0.001 for both), and a statistically significant decrease in LLVAD measurements was found, with a change of –3.0 letters after cataract surgery (P = 0.002). Conclusions: Because of the variable effect of cataracts on LL-BCVA measurements and the significant change in LLVAD measurements after cataract surgery, investigators should be aware that cataract surgery during a trial will have an unpredictable impact on LLVAD measurements, and pseudophakic and phakic patients should be analyzed separately.http://www.sciencedirect.com/science/article/pii/S2666914522000598Cataract surgeryLow luminance visual acuity deficit |
| spellingShingle | Mengxi Shen, MD Yingying Shi, MD Liang Wang, BS Jonathan F. Russell, MD, PhD Xiaoshuang Jiang, MD, PhD Rita Laiginhas, MD, PhD Prashanth Iyer, MD, MPH Omer Trivizki, MD Marie Thulliez, MD Sonia H. Yoo, MD Terri P. Rose, OD, FAAO Ranya G. Habash, MD Guillermo Amescua, MD William J. Feuer, MS Giovanni Gregori, PhD Philip J. Rosenfeld, MD, PhD Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements Ophthalmology Science Cataract surgery Low luminance visual acuity deficit |
| title | Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements |
| title_full | Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements |
| title_fullStr | Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements |
| title_full_unstemmed | Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements |
| title_short | Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements |
| title_sort | impact of cataract surgery on low luminance visual acuity deficit measurements |
| topic | Cataract surgery Low luminance visual acuity deficit |
| url | http://www.sciencedirect.com/science/article/pii/S2666914522000598 |
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