Efficacy of Nitazoxanide, Nitazoxanide-Garlic Combination and Tinidazole in Treatment of Giardia duodenalis and Blastocystis hominis: Coproscopic Assessment
Background: Giardia duodenalis and Blastocystis hominis are among the most common intestinal protozoa worldwide. Treatment of infection by metronidazole (MTZ) has some limitations. The objective of this study was to detect the prevalence of Blastocystis and giardiasis among school-age children from...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-03-01
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| Series: | Iranian Journal of Parasitology |
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| Online Access: | https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3664 |
| _version_ | 1827960718978187264 |
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| author | Sarah Mohamed Abdo Marwa Mohamed Ibrahim Ghallab Ghallab Mariam S. Zaghloul Heba Elhadad |
| author_facet | Sarah Mohamed Abdo Marwa Mohamed Ibrahim Ghallab Ghallab Mariam S. Zaghloul Heba Elhadad |
| author_sort | Sarah Mohamed Abdo |
| collection | DOAJ |
| description |
Background: Giardia duodenalis and Blastocystis hominis are among the most common intestinal protozoa worldwide. Treatment of infection by metronidazole (MTZ) has some limitations. The objective of this study was to detect the prevalence of Blastocystis and giardiasis among school-age children from December 2021 till March 2022 from Motoubes, Kafrelsheikh, Egypt, and determine the efficacy of nitazoxanide (NTZ), NTZ plus garlic and tinidazole (TIN) on Blastocystis and giardiasis infection.
Methods: Stool samples were collected from 390 children and microscopically examined using formalin-ethyl acetate concentration and culturing on Jones' medium for B. hominis. Those who tested positive for giardiasis (120 children, 30.7%) (Group I) or Blastocystis (180 children, 46.1%) (Group II) were equally divided into four subgroups. The first subgroup received NTZ orally, every 12 hours for three successive days. The second subgroup received NTZ in the same dose as the first subgroup plus dry garlic powder every 12 hours for three successive days. The third subgroup received TIN as a single oral dose, and a fourth control subgroup. Successful cure was considered if no Blastocystis or giardiasis stages were found in post-treatment faecal specimens.
Results: Cure rate was significantly higher in TIN treated groups (75.5% and 96.6%) than NTZ (57.7% and 40% ) or NTZ plus garlic treated groups ( 55.5% and 43%) in both Blastocystis and giardiasis, respectively (P<0.05).
Conclusion: TIN, once, is more efficacious than NTZ or NTZ plus garlic in the treatment of Blastocystis and giardiasis in children.
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| first_indexed | 2024-04-09T16:13:58Z |
| format | Article |
| id | doaj.art-d2cd79d63ddc4ddf80ee2d542a3589f7 |
| institution | Directory Open Access Journal |
| issn | 1735-7020 2008-238X |
| language | English |
| last_indexed | 2024-04-09T16:13:58Z |
| publishDate | 2023-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Parasitology |
| spelling | doaj.art-d2cd79d63ddc4ddf80ee2d542a3589f72023-04-24T06:56:04ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2023-03-0118110.18502/ijpa.v18i1.12379Efficacy of Nitazoxanide, Nitazoxanide-Garlic Combination and Tinidazole in Treatment of Giardia duodenalis and Blastocystis hominis: Coproscopic AssessmentSarah Mohamed Abdo0Marwa Mohamed Ibrahim Ghallab Ghallab1Mariam S. Zaghloul2Heba Elhadad3Department of Medical Parasitology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 35516, EgyptDepartment of Medical Parasitology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 35516, EgyptDepartment of Hepatology, Gastroenterology and Infectious Diseases, Kafrelshiekh University, 33516, Kafrelsheikh, EgyptParasitology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt Background: Giardia duodenalis and Blastocystis hominis are among the most common intestinal protozoa worldwide. Treatment of infection by metronidazole (MTZ) has some limitations. The objective of this study was to detect the prevalence of Blastocystis and giardiasis among school-age children from December 2021 till March 2022 from Motoubes, Kafrelsheikh, Egypt, and determine the efficacy of nitazoxanide (NTZ), NTZ plus garlic and tinidazole (TIN) on Blastocystis and giardiasis infection. Methods: Stool samples were collected from 390 children and microscopically examined using formalin-ethyl acetate concentration and culturing on Jones' medium for B. hominis. Those who tested positive for giardiasis (120 children, 30.7%) (Group I) or Blastocystis (180 children, 46.1%) (Group II) were equally divided into four subgroups. The first subgroup received NTZ orally, every 12 hours for three successive days. The second subgroup received NTZ in the same dose as the first subgroup plus dry garlic powder every 12 hours for three successive days. The third subgroup received TIN as a single oral dose, and a fourth control subgroup. Successful cure was considered if no Blastocystis or giardiasis stages were found in post-treatment faecal specimens. Results: Cure rate was significantly higher in TIN treated groups (75.5% and 96.6%) than NTZ (57.7% and 40% ) or NTZ plus garlic treated groups ( 55.5% and 43%) in both Blastocystis and giardiasis, respectively (P<0.05). Conclusion: TIN, once, is more efficacious than NTZ or NTZ plus garlic in the treatment of Blastocystis and giardiasis in children. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3664Giardia duodenalisBlastocystis hominisTinidazoleNitazoxanideGarlic |
| spellingShingle | Sarah Mohamed Abdo Marwa Mohamed Ibrahim Ghallab Ghallab Mariam S. Zaghloul Heba Elhadad Efficacy of Nitazoxanide, Nitazoxanide-Garlic Combination and Tinidazole in Treatment of Giardia duodenalis and Blastocystis hominis: Coproscopic Assessment Iranian Journal of Parasitology Giardia duodenalis Blastocystis hominis Tinidazole Nitazoxanide Garlic |
| title | Efficacy of Nitazoxanide, Nitazoxanide-Garlic Combination and Tinidazole in Treatment of Giardia duodenalis and Blastocystis hominis: Coproscopic Assessment |
| title_full | Efficacy of Nitazoxanide, Nitazoxanide-Garlic Combination and Tinidazole in Treatment of Giardia duodenalis and Blastocystis hominis: Coproscopic Assessment |
| title_fullStr | Efficacy of Nitazoxanide, Nitazoxanide-Garlic Combination and Tinidazole in Treatment of Giardia duodenalis and Blastocystis hominis: Coproscopic Assessment |
| title_full_unstemmed | Efficacy of Nitazoxanide, Nitazoxanide-Garlic Combination and Tinidazole in Treatment of Giardia duodenalis and Blastocystis hominis: Coproscopic Assessment |
| title_short | Efficacy of Nitazoxanide, Nitazoxanide-Garlic Combination and Tinidazole in Treatment of Giardia duodenalis and Blastocystis hominis: Coproscopic Assessment |
| title_sort | efficacy of nitazoxanide nitazoxanide garlic combination and tinidazole in treatment of giardia duodenalis and blastocystis hominis coproscopic assessment |
| topic | Giardia duodenalis Blastocystis hominis Tinidazole Nitazoxanide Garlic |
| url | https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3664 |
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