Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

RNA splicing plays a fundamental role in human biology. Its relevance in cancer is rapidly emerging as demonstrated by spliceosome mutations that determine the prognosis of patients with hematologic malignancies. We report studies using FD-895 and pladienolide-B in primary leukemia cells derived fro...

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Príomhchruthaitheoirí: Manoj K. Kashyap, Deepak Kumar, Reymundo Villa, James J. La Clair, Chris Benner, Roman Sasik, Harrison Jones, Emanuela M. Ghia, Laura Z. Rassenti, Thomas J. Kipps, Michael D. Burkart, Januario E. Castro
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Ferrata Storti Foundation 2015-07-01
Sraith:Haematologica
Rochtain ar líne:https://haematologica.org/article/view/7440

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https://haematologica.org/article/view/7440

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