A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors
Although emerging patient-derived samples and cellular-based evidence support the relationship between WDR74 (WD Repeat Domain 74) and carcinogenesis in multiple cancers, no systematic pan-cancer analysis is available. Our preliminary research demonstrated that WDR74 is over-expressed in lung squamo...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.860940/full |
| _version_ | 1818048432993992704 |
|---|---|
| author | Xiaoxuan Wu Peng Song Shun Wang Zhirong Qian Zhirong Qian Zhirong Qian Jianming Ying Shugeng Gao Wenbin Li |
| author_facet | Xiaoxuan Wu Peng Song Shun Wang Zhirong Qian Zhirong Qian Zhirong Qian Jianming Ying Shugeng Gao Wenbin Li |
| author_sort | Xiaoxuan Wu |
| collection | DOAJ |
| description | Although emerging patient-derived samples and cellular-based evidence support the relationship between WDR74 (WD Repeat Domain 74) and carcinogenesis in multiple cancers, no systematic pan-cancer analysis is available. Our preliminary research demonstrated that WDR74 is over-expressed in lung squamous cell carcinoma (LUSC) and related with worse survival. We thus investigated the potential oncogenic roles of WDR74 across 33 tumors based on the database of TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus). WDR74 is highly expressed in most cancers and correlated with poor prognosis in several cancers (all p < 0.05). Mutation analysis demonstrated that WDR74 is frequently mutated in promoter regions of lung cancer. Moreover, we found that CD8+ T-cells and the fibroblast infiltration level increased in WDR74 over-expressed cancer cells. The GO (Gene Ontology) enrichment analysis of the WDR74 pathway revealed its participation in cellular biogenesis of the RNA metabolism and its critical role in cancer initiation and progression through the tumor cell energy metabolism. Our first pan-cancer study inferred a relatively comprehensive understanding of the oncogenic roles of WDR74 across various cancers. |
| first_indexed | 2024-12-10T10:21:36Z |
| format | Article |
| id | doaj.art-d2cfc0b9a02a469895799f5326dcfdc0 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T10:21:36Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-d2cfc0b9a02a469895799f5326dcfdc02022-12-22T01:52:51ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.860940860940A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple TumorsXiaoxuan Wu0Peng Song1Shun Wang2Zhirong Qian3Zhirong Qian4Zhirong Qian5Jianming Ying6Shugeng Gao7Wenbin Li8Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Thoracic Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBeidou Academic and Research Center, Beidou Life Science, Guangzhou, ChinaBeidou Academic and Research Center, Beidou Life Science, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Digestive Cancer Research, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, ChinaDepartment of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Thoracic Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaAlthough emerging patient-derived samples and cellular-based evidence support the relationship between WDR74 (WD Repeat Domain 74) and carcinogenesis in multiple cancers, no systematic pan-cancer analysis is available. Our preliminary research demonstrated that WDR74 is over-expressed in lung squamous cell carcinoma (LUSC) and related with worse survival. We thus investigated the potential oncogenic roles of WDR74 across 33 tumors based on the database of TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus). WDR74 is highly expressed in most cancers and correlated with poor prognosis in several cancers (all p < 0.05). Mutation analysis demonstrated that WDR74 is frequently mutated in promoter regions of lung cancer. Moreover, we found that CD8+ T-cells and the fibroblast infiltration level increased in WDR74 over-expressed cancer cells. The GO (Gene Ontology) enrichment analysis of the WDR74 pathway revealed its participation in cellular biogenesis of the RNA metabolism and its critical role in cancer initiation and progression through the tumor cell energy metabolism. Our first pan-cancer study inferred a relatively comprehensive understanding of the oncogenic roles of WDR74 across various cancers.https://www.frontiersin.org/articles/10.3389/fgene.2022.860940/fullpan-cancer analysisWD repeat domain 74oncologybioinformatics analysiscarcinogenesis |
| spellingShingle | Xiaoxuan Wu Peng Song Shun Wang Zhirong Qian Zhirong Qian Zhirong Qian Jianming Ying Shugeng Gao Wenbin Li A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors Frontiers in Genetics pan-cancer analysis WD repeat domain 74 oncology bioinformatics analysis carcinogenesis |
| title | A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors |
| title_full | A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors |
| title_fullStr | A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors |
| title_full_unstemmed | A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors |
| title_short | A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors |
| title_sort | pan cancer analysis of the oncogenic role of wd repeat domain 74 in multiple tumors |
| topic | pan-cancer analysis WD repeat domain 74 oncology bioinformatics analysis carcinogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.860940/full |
| work_keys_str_mv | AT xiaoxuanwu apancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT pengsong apancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT shunwang apancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT zhirongqian apancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT zhirongqian apancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT zhirongqian apancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT jianmingying apancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT shugenggao apancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT wenbinli apancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT xiaoxuanwu pancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT pengsong pancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT shunwang pancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT zhirongqian pancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT zhirongqian pancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT zhirongqian pancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT jianmingying pancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT shugenggao pancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors AT wenbinli pancanceranalysisoftheoncogenicroleofwdrepeatdomain74inmultipletumors |