Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics
N6-methyladenosine (m6A) is a representative of RNA methylation modification, which plays a critical role in the epigenetic modification process of regulating human diseases. As a key protein for m6A, methyltransferase 3 (METTL3) had been identified to be associated with a variety of diseases. The p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-03-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-0586 |
| _version_ | 1797848733183901696 |
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| author | Liu Hanqi Huang Yanqing Lu Shanshan Yuan Didi Liu Junwen |
| author_facet | Liu Hanqi Huang Yanqing Lu Shanshan Yuan Didi Liu Junwen |
| author_sort | Liu Hanqi |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) is a representative of RNA methylation modification, which plays a critical role in the epigenetic modification process of regulating human diseases. As a key protein for m6A, methyltransferase 3 (METTL3) had been identified to be associated with a variety of diseases. The publications related to METTL3 were searched in the Web of Science Core Collection from the earliest mention to July 1st, 2022. Being screened by the retrieval strategy, a total of 1,738 articles related to METTL3 were retrieved. Much of our work focused on collecting the data of annual publication outputs, high-yielding countries/regions/authors, keywords, citations, and journals frequently published for qualitative and quantitative analysis. We found that diseases with high correlations to METTL3 not only included various known cancers but also obesity and atherosclerosis. In addition to m6A-related enzyme molecules, the most frequent key molecules were MYC proto-oncogene (C-MYC), Enhancer of zeste homolog 2 (EZH2), and Phosphatase and tensin homolog deleted on chromosome 10 (PTEN). METTL3 and methyltransferase 14 (METTL14) may function through opposite regulatory pathways in the same disease. “Leukemia,” “Liver Cancer,” and “Glioblastoma” were speculated to be potential hotspots in METTL3 related study. The number of publications had significantly surged year by year, demonstrating the growing importance of the research on epigenetic modification in the pathology of various diseases. |
| first_indexed | 2024-04-09T18:33:29Z |
| format | Article |
| id | doaj.art-d2d0668585cc463f903dcf96ec47a12b |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-09T18:33:29Z |
| publishDate | 2023-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-d2d0668585cc463f903dcf96ec47a12b2023-04-11T17:07:13ZengDe GruyterOpen Life Sciences2391-54122023-03-01181204910.1515/biol-2022-0586Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topicsLiu Hanqi0Huang Yanqing1Lu Shanshan2Yuan Didi3Liu Junwen4Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 420013, ChinaDepartment of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 420013, ChinaDepartment of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 420013, ChinaDepartment of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 420013, ChinaDepartment of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 420013, ChinaN6-methyladenosine (m6A) is a representative of RNA methylation modification, which plays a critical role in the epigenetic modification process of regulating human diseases. As a key protein for m6A, methyltransferase 3 (METTL3) had been identified to be associated with a variety of diseases. The publications related to METTL3 were searched in the Web of Science Core Collection from the earliest mention to July 1st, 2022. Being screened by the retrieval strategy, a total of 1,738 articles related to METTL3 were retrieved. Much of our work focused on collecting the data of annual publication outputs, high-yielding countries/regions/authors, keywords, citations, and journals frequently published for qualitative and quantitative analysis. We found that diseases with high correlations to METTL3 not only included various known cancers but also obesity and atherosclerosis. In addition to m6A-related enzyme molecules, the most frequent key molecules were MYC proto-oncogene (C-MYC), Enhancer of zeste homolog 2 (EZH2), and Phosphatase and tensin homolog deleted on chromosome 10 (PTEN). METTL3 and methyltransferase 14 (METTL14) may function through opposite regulatory pathways in the same disease. “Leukemia,” “Liver Cancer,” and “Glioblastoma” were speculated to be potential hotspots in METTL3 related study. The number of publications had significantly surged year by year, demonstrating the growing importance of the research on epigenetic modification in the pathology of various diseases.https://doi.org/10.1515/biol-2022-0586mettl3publicationsbibliometricsrna methylationepigenetics |
| spellingShingle | Liu Hanqi Huang Yanqing Lu Shanshan Yuan Didi Liu Junwen Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics Open Life Sciences mettl3 publications bibliometrics rna methylation epigenetics |
| title | Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics |
| title_full | Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics |
| title_fullStr | Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics |
| title_full_unstemmed | Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics |
| title_short | Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics |
| title_sort | bibliometric analysis of mettl3 current perspectives highlights and trending topics |
| topic | mettl3 publications bibliometrics rna methylation epigenetics |
| url | https://doi.org/10.1515/biol-2022-0586 |
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