Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos
Applications and indications of assisted reproduction technology are expanding, but every new approach is under scrutiny and thorough consideration. Recently, groups of assisted reproduction experts have presented data that support the clinical use of mosaic preimplantation embryos at the blastocyst...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | https://www.mdpi.com/2221-3759/9/2/18 |
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| author | Ioanna Bouba Elissavet Hatzi Paris Ladias Prodromos Sakaloglou Charilaos Kostoulas Ioannis Georgiou |
| author_facet | Ioanna Bouba Elissavet Hatzi Paris Ladias Prodromos Sakaloglou Charilaos Kostoulas Ioannis Georgiou |
| author_sort | Ioanna Bouba |
| collection | DOAJ |
| description | Applications and indications of assisted reproduction technology are expanding, but every new approach is under scrutiny and thorough consideration. Recently, groups of assisted reproduction experts have presented data that support the clinical use of mosaic preimplantation embryos at the blastocyst stage, previously excluded from transfer. In the light of published contemporary studies, with or without clinical outcomes, there is growing evidence that mosaic embryos have the capacity for further in utero development and live birth. Our in-depth discussion will enable readers to better comprehend current developments. This expansion into the spectrum of ART practices requires further evidence and further theoretical documentation, basic research, and ethical support. Therefore, if strict criteria for selecting competent mosaic preimplantation embryos for further transfer, implantation, fetal growth, and healthy birth are applied, fewer embryos will be excluded, and more live births will be achieved. Our review aims to discuss the recent literature on the transfer of mosaic preimplantation embryos. It also highlights controversies as far as the clinical utilization of preimplantation embryos concerns. Finally, it provides the appropriate background to elucidate and highlight cellular and genetic aspects of this novel direction. |
| first_indexed | 2024-03-10T11:38:56Z |
| format | Article |
| id | doaj.art-d2d11e8ab383484791bd8ba21218b9d5 |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-03-10T11:38:56Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-d2d11e8ab383484791bd8ba21218b9d52023-11-21T18:38:15ZengMDPI AGJournal of Developmental Biology2221-37592021-05-01921810.3390/jdb9020018Biological and Clinical Significance of Mosaicism in Human Preimplantation EmbryosIoanna Bouba0Elissavet Hatzi1Paris Ladias2Prodromos Sakaloglou3Charilaos Kostoulas4Ioannis Georgiou5Laboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceIVF and Genetics Unit, Dept of Obstetrics and Gynecology, University Hospital of Ioannina, 45500 Ioannina, GreeceLaboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceLaboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceLaboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceLaboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceApplications and indications of assisted reproduction technology are expanding, but every new approach is under scrutiny and thorough consideration. Recently, groups of assisted reproduction experts have presented data that support the clinical use of mosaic preimplantation embryos at the blastocyst stage, previously excluded from transfer. In the light of published contemporary studies, with or without clinical outcomes, there is growing evidence that mosaic embryos have the capacity for further in utero development and live birth. Our in-depth discussion will enable readers to better comprehend current developments. This expansion into the spectrum of ART practices requires further evidence and further theoretical documentation, basic research, and ethical support. Therefore, if strict criteria for selecting competent mosaic preimplantation embryos for further transfer, implantation, fetal growth, and healthy birth are applied, fewer embryos will be excluded, and more live births will be achieved. Our review aims to discuss the recent literature on the transfer of mosaic preimplantation embryos. It also highlights controversies as far as the clinical utilization of preimplantation embryos concerns. Finally, it provides the appropriate background to elucidate and highlight cellular and genetic aspects of this novel direction.https://www.mdpi.com/2221-3759/9/2/18human mosaic embryospreimplantation genetic testingassisted reproduction |
| spellingShingle | Ioanna Bouba Elissavet Hatzi Paris Ladias Prodromos Sakaloglou Charilaos Kostoulas Ioannis Georgiou Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos Journal of Developmental Biology human mosaic embryos preimplantation genetic testing assisted reproduction |
| title | Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos |
| title_full | Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos |
| title_fullStr | Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos |
| title_full_unstemmed | Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos |
| title_short | Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos |
| title_sort | biological and clinical significance of mosaicism in human preimplantation embryos |
| topic | human mosaic embryos preimplantation genetic testing assisted reproduction |
| url | https://www.mdpi.com/2221-3759/9/2/18 |
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