Assessment of nano-iron particles impact on the reproductive health of female Wistar rats
Abstract Background Iron oxide nanoparticles, especially nano-magnetite, are promising candidates for use in a variety of applications. The present study aimed to investigate the effect of nano-magnetite on the reproductive health of female Wistar rats. Twenty-one adult female rats were divided into...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-07-01
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| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43088-022-00274-4 |
| _version_ | 1811223075996303360 |
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| author | Menna-Tullah Magdy Abd EL-Wahab A EL-Ghareeb Fawzy A Attaby Heba A Abd El-Rahman |
| author_facet | Menna-Tullah Magdy Abd EL-Wahab A EL-Ghareeb Fawzy A Attaby Heba A Abd El-Rahman |
| author_sort | Menna-Tullah Magdy |
| collection | DOAJ |
| description | Abstract Background Iron oxide nanoparticles, especially nano-magnetite, are promising candidates for use in a variety of applications. The present study aimed to investigate the effect of nano-magnetite on the reproductive health of female Wistar rats. Twenty-one adult female rats were divided into three groups: Group 1 served as the control group, Group 2 received a low dose of 5 mg/kg of nano-magnetite, and Group 3 received a high dose of 10 mg/kg of nano-magnetite. For 30 days, rats were intraperitoneally injected three times per week. The main findings Revealed that nano-magnetite did not induce a change in body weight or absolute as well as relative reproductive organs weight. Nano-magnetite nanoparticles influenced the reproductive serum hormone levels as well as imbalanced the ovarian and uterine malondialdehyde and total antioxidant activity. After nano-magnetite nanoparticle injection, the histopathological examination revealed apoptosis of granulosa cells of various types of follicles, degenerated corpora lutea, congested blood vessels, and uterine epithelial cells of uterine tissue showed a high level of apoptosis and inflammation. Immunohistochemistry studies demonstrated a significant increase in activated caspase-3 following nano-magnetite injection, indicating an increase in cell apoptosis. Conclusion This study demonstrated the negative effect of magnetite nanoparticle on reproductive health and increased the likelihood of infertility. |
| first_indexed | 2024-04-12T08:25:48Z |
| format | Article |
| id | doaj.art-d2d446546c71465d9ba814a080e02cbd |
| institution | Directory Open Access Journal |
| issn | 2314-8543 |
| language | English |
| last_indexed | 2024-04-12T08:25:48Z |
| publishDate | 2022-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj.art-d2d446546c71465d9ba814a080e02cbd2022-12-22T03:40:23ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85432022-07-0111111610.1186/s43088-022-00274-4Assessment of nano-iron particles impact on the reproductive health of female Wistar ratsMenna-Tullah Magdy0Abd EL-Wahab A EL-Ghareeb1Fawzy A Attaby2Heba A Abd El-Rahman3Department of Chemistry, Biotechnology, Faculty of Science, Cairo UniversityDepartment of Zoology, Faculty of Science, Cairo UniversityDepartment of Chemistry, Faculty of Science, Cairo UniversityDepartment of Zoology, Faculty of Science, Cairo UniversityAbstract Background Iron oxide nanoparticles, especially nano-magnetite, are promising candidates for use in a variety of applications. The present study aimed to investigate the effect of nano-magnetite on the reproductive health of female Wistar rats. Twenty-one adult female rats were divided into three groups: Group 1 served as the control group, Group 2 received a low dose of 5 mg/kg of nano-magnetite, and Group 3 received a high dose of 10 mg/kg of nano-magnetite. For 30 days, rats were intraperitoneally injected three times per week. The main findings Revealed that nano-magnetite did not induce a change in body weight or absolute as well as relative reproductive organs weight. Nano-magnetite nanoparticles influenced the reproductive serum hormone levels as well as imbalanced the ovarian and uterine malondialdehyde and total antioxidant activity. After nano-magnetite nanoparticle injection, the histopathological examination revealed apoptosis of granulosa cells of various types of follicles, degenerated corpora lutea, congested blood vessels, and uterine epithelial cells of uterine tissue showed a high level of apoptosis and inflammation. Immunohistochemistry studies demonstrated a significant increase in activated caspase-3 following nano-magnetite injection, indicating an increase in cell apoptosis. Conclusion This study demonstrated the negative effect of magnetite nanoparticle on reproductive health and increased the likelihood of infertility.https://doi.org/10.1186/s43088-022-00274-4Magnetite nanoparticlesFemale Wistar ratReproductive healthHistopathologyHormones |
| spellingShingle | Menna-Tullah Magdy Abd EL-Wahab A EL-Ghareeb Fawzy A Attaby Heba A Abd El-Rahman Assessment of nano-iron particles impact on the reproductive health of female Wistar rats Beni-Suef University Journal of Basic and Applied Sciences Magnetite nanoparticles Female Wistar rat Reproductive health Histopathology Hormones |
| title | Assessment of nano-iron particles impact on the reproductive health of female Wistar rats |
| title_full | Assessment of nano-iron particles impact on the reproductive health of female Wistar rats |
| title_fullStr | Assessment of nano-iron particles impact on the reproductive health of female Wistar rats |
| title_full_unstemmed | Assessment of nano-iron particles impact on the reproductive health of female Wistar rats |
| title_short | Assessment of nano-iron particles impact on the reproductive health of female Wistar rats |
| title_sort | assessment of nano iron particles impact on the reproductive health of female wistar rats |
| topic | Magnetite nanoparticles Female Wistar rat Reproductive health Histopathology Hormones |
| url | https://doi.org/10.1186/s43088-022-00274-4 |
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