Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls
Rumination is a significant risk factor for psychopathology in adolescent girls and is associated with heightened and prolonged physiological arousal following social rejection. However, no study has examined how rumination relates to neural responses to social rejection in adolescent girls; thus, t...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323001251 |
| _version_ | 1827591294004756480 |
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| author | Leehyun Yoon Kate E. Keenan Alison E. Hipwell Erika E. Forbes Amanda E. Guyer |
| author_facet | Leehyun Yoon Kate E. Keenan Alison E. Hipwell Erika E. Forbes Amanda E. Guyer |
| author_sort | Leehyun Yoon |
| collection | DOAJ |
| description | Rumination is a significant risk factor for psychopathology in adolescent girls and is associated with heightened and prolonged physiological arousal following social rejection. However, no study has examined how rumination relates to neural responses to social rejection in adolescent girls; thus, the current study aimed to address this gap. Adolescent girls (N = 116; ages 16.95–19.09) self-reported on their rumination tendency and completed a social evaluation fMRI task where they received fictitious feedback (acceptance, rejection) from peers they liked or disliked. Rejection-related neural activity and subgenual anterior cingulate cortex (sgACC) connectivity were regressed on rumination, controlling for rejection sensitivity and depressive symptoms. Rumination was associated with distinctive neural responses following rejection from liked peers including increased neural activity in the precuneus, inferior parietal gyrus, dorsolateral prefrontal cortex, and supplementary motor area (SMA) and reduced sgACC connectivity with multiple regions including medial prefrontal cortex, precuneus and ventrolateral prefrontal cortex. Greater precuneus and SMA activity mediated the effect of rumination on slower response time to report emotional state after receiving rejection from liked peers. These findings provide clues for distinctive cognitive processes (e.g., mentalizing, conflict processing, memory encoding) following the receipt of rejection in girls with high levels of rumination. |
| first_indexed | 2024-03-09T01:29:45Z |
| format | Article |
| id | doaj.art-d2d5bf6485f74e9e9416306703a21d8a |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-09T01:29:45Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-d2d5bf6485f74e9e9416306703a21d8a2023-12-10T06:14:25ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-12-0164101320Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girlsLeehyun Yoon0Kate E. Keenan1Alison E. Hipwell2Erika E. Forbes3Amanda E. Guyer4Center for Mind and Brain, University of California, Davis, Davis, CA 95618, USADepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USACenter for Mind and Brain, University of California, Davis, Davis, CA 95618, USA; Department of Human Ecology, University of California, Davis, Davis, CA 95616, USA; Correspondence to: Department of Human Ecology, Center for Mind and Brain, University of California Davis, 267 Cousteau Place, Davis, CA 95618, USA.Rumination is a significant risk factor for psychopathology in adolescent girls and is associated with heightened and prolonged physiological arousal following social rejection. However, no study has examined how rumination relates to neural responses to social rejection in adolescent girls; thus, the current study aimed to address this gap. Adolescent girls (N = 116; ages 16.95–19.09) self-reported on their rumination tendency and completed a social evaluation fMRI task where they received fictitious feedback (acceptance, rejection) from peers they liked or disliked. Rejection-related neural activity and subgenual anterior cingulate cortex (sgACC) connectivity were regressed on rumination, controlling for rejection sensitivity and depressive symptoms. Rumination was associated with distinctive neural responses following rejection from liked peers including increased neural activity in the precuneus, inferior parietal gyrus, dorsolateral prefrontal cortex, and supplementary motor area (SMA) and reduced sgACC connectivity with multiple regions including medial prefrontal cortex, precuneus and ventrolateral prefrontal cortex. Greater precuneus and SMA activity mediated the effect of rumination on slower response time to report emotional state after receiving rejection from liked peers. These findings provide clues for distinctive cognitive processes (e.g., mentalizing, conflict processing, memory encoding) following the receipt of rejection in girls with high levels of rumination.http://www.sciencedirect.com/science/article/pii/S1878929323001251RuminationAdolescenceSocial rejectionfMRIsgACCDefault mode network |
| spellingShingle | Leehyun Yoon Kate E. Keenan Alison E. Hipwell Erika E. Forbes Amanda E. Guyer Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls Developmental Cognitive Neuroscience Rumination Adolescence Social rejection fMRI sgACC Default mode network |
| title | Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls |
| title_full | Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls |
| title_fullStr | Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls |
| title_full_unstemmed | Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls |
| title_short | Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls |
| title_sort | hooked on a thought associations between rumination and neural responses to social rejection in adolescent girls |
| topic | Rumination Adolescence Social rejection fMRI sgACC Default mode network |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323001251 |
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