High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes
Novel metal-based compounds with therapeutic potential became the subject of intense investigation in inorganic chemistry and biomedical science. Recently, strong dose-dependent cytotoxic activity against several human cancer cell lines of selenosemicarbazone metal complexes was demonstrate...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Serbian Chemical Society
2013-01-01
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Series: | Journal of the Serbian Chemical Society |
Subjects: | |
Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391300035D.pdf |
Summary: | Novel metal-based compounds with therapeutic potential became the subject of
intense investigation in inorganic chemistry and biomedical science.
Recently, strong dose-dependent cytotoxic activity against several human
cancer cell lines of selenosemicarbazone metal complexes was demonstrated.
The aim of the present study was to investigate in vitro antioxidative
potential of Ni(II), Cd(II) and Zn(II) selenosemicarbazone complexes. All
three investigated complexes exhibited high ABTS radical scavenging capacity,
comparable with ascorbic acid. In the acute toxicity study, administration of
the compounds was performed orally to the mice at the single doses and they
were observed for clinical signs, body weight effects, and mortality for 14
days after which they were sacrificed for gross organ necropsy. Body weight
did not vary after administration, and the autoptic analysis failed to show
appreciable macroscopic alterations of internal organs. Generally, the
compounds exhibited low toxic effects as required for further in vivo
therapeutic studies. [Projekat Ministarstva nauke Republike Srbije, br.
451-03-2372-IP type 1/79: Antioxidants based on selenium complex compounds -
research and development] |
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ISSN: | 0352-5139 1820-7421 |