High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes
Novel metal-based compounds with therapeutic potential became the subject of intense investigation in inorganic chemistry and biomedical science. Recently, strong dose-dependent cytotoxic activity against several human cancer cell lines of selenosemicarbazone metal complexes was demonstrate...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2013-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391300035D.pdf |
| _version_ | 1811249035472797696 |
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| author | Dekanski Dragana Todorović Tamara Mitić Dragana Filipović Nenad Polović Natalija Anđelković Katarina |
| author_facet | Dekanski Dragana Todorović Tamara Mitić Dragana Filipović Nenad Polović Natalija Anđelković Katarina |
| author_sort | Dekanski Dragana |
| collection | DOAJ |
| description | Novel metal-based compounds with therapeutic potential became the subject of
intense investigation in inorganic chemistry and biomedical science.
Recently, strong dose-dependent cytotoxic activity against several human
cancer cell lines of selenosemicarbazone metal complexes was demonstrated.
The aim of the present study was to investigate in vitro antioxidative
potential of Ni(II), Cd(II) and Zn(II) selenosemicarbazone complexes. All
three investigated complexes exhibited high ABTS radical scavenging capacity,
comparable with ascorbic acid. In the acute toxicity study, administration of
the compounds was performed orally to the mice at the single doses and they
were observed for clinical signs, body weight effects, and mortality for 14
days after which they were sacrificed for gross organ necropsy. Body weight
did not vary after administration, and the autoptic analysis failed to show
appreciable macroscopic alterations of internal organs. Generally, the
compounds exhibited low toxic effects as required for further in vivo
therapeutic studies. [Projekat Ministarstva nauke Republike Srbije, br.
451-03-2372-IP type 1/79: Antioxidants based on selenium complex compounds -
research and development] |
| first_indexed | 2024-04-12T15:39:22Z |
| format | Article |
| id | doaj.art-d2d64d5cdac746448e2a62d98b380a38 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-04-12T15:39:22Z |
| publishDate | 2013-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-d2d64d5cdac746448e2a62d98b380a382022-12-22T03:26:52ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212013-01-0178101503151210.2298/JSC130315035D0352-51391300035DHigh antioxidative potential and low toxic effects of selenosemicarbazone metal complexesDekanski Dragana0Todorović Tamara1Mitić Dragana2Filipović Nenad3Polović Natalija4Anđelković Katarina5Biomedical Research, R&D Institute, Galenika, BelgradeFaculty of Chemistry, BelgradeFaculty of Chemistry, BelgradeFaculty of Agriculture, BelgradeFaculty of Chemistry, BelgradeFaculty of Chemistry, BelgradeNovel metal-based compounds with therapeutic potential became the subject of intense investigation in inorganic chemistry and biomedical science. Recently, strong dose-dependent cytotoxic activity against several human cancer cell lines of selenosemicarbazone metal complexes was demonstrated. The aim of the present study was to investigate in vitro antioxidative potential of Ni(II), Cd(II) and Zn(II) selenosemicarbazone complexes. All three investigated complexes exhibited high ABTS radical scavenging capacity, comparable with ascorbic acid. In the acute toxicity study, administration of the compounds was performed orally to the mice at the single doses and they were observed for clinical signs, body weight effects, and mortality for 14 days after which they were sacrificed for gross organ necropsy. Body weight did not vary after administration, and the autoptic analysis failed to show appreciable macroscopic alterations of internal organs. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies. [Projekat Ministarstva nauke Republike Srbije, br. 451-03-2372-IP type 1/79: Antioxidants based on selenium complex compounds - research and development]http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391300035D.pdfNi(II)Cd(II) and Zn(II) complexesselenosemicarbazonesantioxidative activityin vivo toxicity |
| spellingShingle | Dekanski Dragana Todorović Tamara Mitić Dragana Filipović Nenad Polović Natalija Anđelković Katarina High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes Journal of the Serbian Chemical Society Ni(II) Cd(II) and Zn(II) complexes selenosemicarbazones antioxidative activity in vivo toxicity |
| title | High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes |
| title_full | High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes |
| title_fullStr | High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes |
| title_full_unstemmed | High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes |
| title_short | High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes |
| title_sort | high antioxidative potential and low toxic effects of selenosemicarbazone metal complexes |
| topic | Ni(II) Cd(II) and Zn(II) complexes selenosemicarbazones antioxidative activity in vivo toxicity |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391300035D.pdf |
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