Antioxidant supplements and cognition in Multiple Sclerosis: a systematic review
Background: Cognitive dysfunction is a debilitating characteristic of multiple sclerosis (MS) that affects approximately 60% of patients. To date, the only effective treatments for cognitive decline are cognitive rehabilitation and exercise training. While previous studies reported the beneficial ef...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2022-12-01
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| Series: | Neurology Letters |
| Subjects: | |
| Online Access: | https://www.neurologyletters.com/article_164010_d2386f3baa5eb01f87b2d25a0446fc25.pdf |
| _version_ | 1797630558776328192 |
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| author | Fardin Nabizadeh Fatemeh Sodeifian Ali Ghaderi Amir Mohammad Sharafi Mohammad Balabandian |
| author_facet | Fardin Nabizadeh Fatemeh Sodeifian Ali Ghaderi Amir Mohammad Sharafi Mohammad Balabandian |
| author_sort | Fardin Nabizadeh |
| collection | DOAJ |
| description | Background: Cognitive dysfunction is a debilitating characteristic of multiple sclerosis (MS) that affects approximately 60% of patients. To date, the only effective treatments for cognitive decline are cognitive rehabilitation and exercise training. While previous studies reported the beneficial effect of antioxidants on MS patients, several other studies investigated the effect of antioxidant supplements on the cognitive performance of MS patients. We aimed to conduct a systematic review to examine whether there is an association between antioxidants supplements and cognitive performance in MS patients.Methods: We searched PubMed, Embase, Scopus, and Web of Science for the identification of relevant studies in November 2021. We included control trials, cohort, case-control, and cross-sectional studies which showed the effect of any type of antioxidants on cognitive performance in MS patients.Results: After screening 12 papers were included in our study. Our review included three studies that examined the effect of ginkgo Biloba on cognitive performance, two examined the Mediterranean diet, and remained studies each investigated the vitamin A, Omega 5, Omega 3, estriol, epigallocatechin-3-gallate (EGCG), Boswellia papyrifera, and paleolithic diet. Overall, it seems that there were no benefits of antioxidant administration on cognitive performance in MS patients. |
| first_indexed | 2024-03-11T11:09:50Z |
| format | Article |
| id | doaj.art-d2d85bc737214ff89943a14f9b0a7ecc |
| institution | Directory Open Access Journal |
| issn | 2821-1723 |
| language | English |
| last_indexed | 2024-03-11T11:09:50Z |
| publishDate | 2022-12-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Neurology Letters |
| spelling | doaj.art-d2d85bc737214ff89943a14f9b0a7ecc2023-11-12T09:10:18ZengIran University of Medical SciencesNeurology Letters2821-17232022-12-0112486010.52547/nl.1.2.48164010Antioxidant supplements and cognition in Multiple Sclerosis: a systematic reviewFardin Nabizadeh0Fatemeh Sodeifian1Ali Ghaderi2Amir Mohammad Sharafi3Mohammad Balabandian4School of Medicine, Iran University of Medical Sciences, Tehran, IranStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical ScienceStudents Scientific Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, IranStudent's Scientific Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, IranSchool of Medicine, Iran University of Medical Sciences, Tehran, IranBackground: Cognitive dysfunction is a debilitating characteristic of multiple sclerosis (MS) that affects approximately 60% of patients. To date, the only effective treatments for cognitive decline are cognitive rehabilitation and exercise training. While previous studies reported the beneficial effect of antioxidants on MS patients, several other studies investigated the effect of antioxidant supplements on the cognitive performance of MS patients. We aimed to conduct a systematic review to examine whether there is an association between antioxidants supplements and cognitive performance in MS patients.Methods: We searched PubMed, Embase, Scopus, and Web of Science for the identification of relevant studies in November 2021. We included control trials, cohort, case-control, and cross-sectional studies which showed the effect of any type of antioxidants on cognitive performance in MS patients.Results: After screening 12 papers were included in our study. Our review included three studies that examined the effect of ginkgo Biloba on cognitive performance, two examined the Mediterranean diet, and remained studies each investigated the vitamin A, Omega 5, Omega 3, estriol, epigallocatechin-3-gallate (EGCG), Boswellia papyrifera, and paleolithic diet. Overall, it seems that there were no benefits of antioxidant administration on cognitive performance in MS patients.https://www.neurologyletters.com/article_164010_d2386f3baa5eb01f87b2d25a0446fc25.pdfantioxidantscognitionginkgo bilobavitaminsdiet |
| spellingShingle | Fardin Nabizadeh Fatemeh Sodeifian Ali Ghaderi Amir Mohammad Sharafi Mohammad Balabandian Antioxidant supplements and cognition in Multiple Sclerosis: a systematic review Neurology Letters antioxidants cognition ginkgo biloba vitamins diet |
| title | Antioxidant supplements and cognition in Multiple Sclerosis: a systematic review |
| title_full | Antioxidant supplements and cognition in Multiple Sclerosis: a systematic review |
| title_fullStr | Antioxidant supplements and cognition in Multiple Sclerosis: a systematic review |
| title_full_unstemmed | Antioxidant supplements and cognition in Multiple Sclerosis: a systematic review |
| title_short | Antioxidant supplements and cognition in Multiple Sclerosis: a systematic review |
| title_sort | antioxidant supplements and cognition in multiple sclerosis a systematic review |
| topic | antioxidants cognition ginkgo biloba vitamins diet |
| url | https://www.neurologyletters.com/article_164010_d2386f3baa5eb01f87b2d25a0446fc25.pdf |
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