Effect of exercise and pharmacotherapy on non-alcoholic fatty liver disease
Objectives: Nonalcoholic fatty liver disease is one of the emerging liver diseases affecting 20%–30% of the population creating a burden on public health worldwide and has been associated with the causation of multiple diseases. Besides exercise, several drugs are being used in patients based on cli...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-01-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121241227090 |
| _version_ | 1797346324558905344 |
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| author | Amrita Kandel Poonam Pant Sushila Todi Sudhamshu KC Sudip Pandey |
| author_facet | Amrita Kandel Poonam Pant Sushila Todi Sudhamshu KC Sudip Pandey |
| author_sort | Amrita Kandel |
| collection | DOAJ |
| description | Objectives: Nonalcoholic fatty liver disease is one of the emerging liver diseases affecting 20%–30% of the population creating a burden on public health worldwide and has been associated with the causation of multiple diseases. Besides exercise, several drugs are being used in patients based on clinical evidence especially vitamin E, a potent antioxidant to reduce the oxidative stress responsible for the development and progression of nonalcoholic fatty liver disease. This study aims at evaluating the effect of exercise and pharmacotherapy on nonalcoholic fatty liver disease. Design: A prospective follow-up study with purposive sampling was done at a liver clinic for 3 months. Baseline characteristics such as anthropometric measurements and biochemical parameters were recorded and compared after 3 months to determine the effect of therapy. Descriptive analysis using a parametric test was used to assess the change in biochemical parameters and a non-parametric test was applied to find out the association between non-pharmacological and pharmacological approaches. Results: Out of 177 patients, 67.2 % were male and 32.8% were female with the mean age ±SD of 46.8 ± 12.06 years. Mean ± SD weight and body mass index of the patients were changed from 74.88 ± 11.61 kg to 72.37 ± 11.61 kg and from 28.41 ± 4.02 kg/m 2 to 27.31 ± 4.58 kg/m 2 respectively which was found to be statistically significant. There was a significant change in all the biochemical parameters with the p -value < 0.05 through both non-pharmacological and pharmacological approaches. Conclusion: Nonalcoholic fatty liver disease management through exercise and pharmacotherapy shows significant improvement in biochemical parameters indicating that alone or in combination with both approaches play an effective role in treating nonalcoholic fatty liver disease. |
| first_indexed | 2024-03-08T11:31:27Z |
| format | Article |
| id | doaj.art-d2d9af8e74ff49b3b573216753128e7e |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-03-08T11:31:27Z |
| publishDate | 2024-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-d2d9af8e74ff49b3b573216753128e7e2024-01-25T19:04:15ZengSAGE PublishingSAGE Open Medicine2050-31212024-01-011210.1177/20503121241227090Effect of exercise and pharmacotherapy on non-alcoholic fatty liver diseaseAmrita Kandel0Poonam Pant1Sushila Todi2Sudhamshu KC3Sudip Pandey4Pharmacy Program, CiST College, New Baneshwor, Kathmandu, NepalPharmacy Program, CiST College, New Baneshwor, Kathmandu, NepalObstetrics and Gynaecology Departments, Patan Academy of Health Sciences, Kathmandu, NepalHepatology Departments, NAMS, Bir Hospital, Kathmandu, NepalMadan Bhandari University of Science and Technology, Lalitpur, NepalObjectives: Nonalcoholic fatty liver disease is one of the emerging liver diseases affecting 20%–30% of the population creating a burden on public health worldwide and has been associated with the causation of multiple diseases. Besides exercise, several drugs are being used in patients based on clinical evidence especially vitamin E, a potent antioxidant to reduce the oxidative stress responsible for the development and progression of nonalcoholic fatty liver disease. This study aims at evaluating the effect of exercise and pharmacotherapy on nonalcoholic fatty liver disease. Design: A prospective follow-up study with purposive sampling was done at a liver clinic for 3 months. Baseline characteristics such as anthropometric measurements and biochemical parameters were recorded and compared after 3 months to determine the effect of therapy. Descriptive analysis using a parametric test was used to assess the change in biochemical parameters and a non-parametric test was applied to find out the association between non-pharmacological and pharmacological approaches. Results: Out of 177 patients, 67.2 % were male and 32.8% were female with the mean age ±SD of 46.8 ± 12.06 years. Mean ± SD weight and body mass index of the patients were changed from 74.88 ± 11.61 kg to 72.37 ± 11.61 kg and from 28.41 ± 4.02 kg/m 2 to 27.31 ± 4.58 kg/m 2 respectively which was found to be statistically significant. There was a significant change in all the biochemical parameters with the p -value < 0.05 through both non-pharmacological and pharmacological approaches. Conclusion: Nonalcoholic fatty liver disease management through exercise and pharmacotherapy shows significant improvement in biochemical parameters indicating that alone or in combination with both approaches play an effective role in treating nonalcoholic fatty liver disease.https://doi.org/10.1177/20503121241227090 |
| spellingShingle | Amrita Kandel Poonam Pant Sushila Todi Sudhamshu KC Sudip Pandey Effect of exercise and pharmacotherapy on non-alcoholic fatty liver disease SAGE Open Medicine |
| title | Effect of exercise and pharmacotherapy on non-alcoholic fatty liver disease |
| title_full | Effect of exercise and pharmacotherapy on non-alcoholic fatty liver disease |
| title_fullStr | Effect of exercise and pharmacotherapy on non-alcoholic fatty liver disease |
| title_full_unstemmed | Effect of exercise and pharmacotherapy on non-alcoholic fatty liver disease |
| title_short | Effect of exercise and pharmacotherapy on non-alcoholic fatty liver disease |
| title_sort | effect of exercise and pharmacotherapy on non alcoholic fatty liver disease |
| url | https://doi.org/10.1177/20503121241227090 |
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