Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional study
ObjectiveDespite previous research that focused on aspartate aminotransferase/alanine aminotransferase ratio (AAR) as predictors of type 2 diabetes mellitus (T2DM) and cardiovascular disease, there has been limited research evaluating the association between AAR and diabetic microvascular complicati...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1064125/full |
| _version_ | 1828005158698614784 |
|---|---|
| author | Pijun Yan Pijun Yan Pijun Yan Pijun Yan Yuru Wu Yuru Wu Yuru Wu Yuru Wu Xiaofang Dan Xiaofang Dan Xiaofang Dan Xiaofang Dan Xian Wu Xian Wu Xian Wu Xian Wu Qian Tang Qian Tang Qian Tang Qian Tang Xiping Chen Yong Xu Yong Xu Yong Xu Yong Xu Jianhua Zhu Jianhua Zhu Jianhua Zhu Jianhua Zhu Ying Miao Ying Miao Ying Miao Ying Miao Qin Wan Qin Wan Qin Wan Qin Wan |
| author_facet | Pijun Yan Pijun Yan Pijun Yan Pijun Yan Yuru Wu Yuru Wu Yuru Wu Yuru Wu Xiaofang Dan Xiaofang Dan Xiaofang Dan Xiaofang Dan Xian Wu Xian Wu Xian Wu Xian Wu Qian Tang Qian Tang Qian Tang Qian Tang Xiping Chen Yong Xu Yong Xu Yong Xu Yong Xu Jianhua Zhu Jianhua Zhu Jianhua Zhu Jianhua Zhu Ying Miao Ying Miao Ying Miao Ying Miao Qin Wan Qin Wan Qin Wan Qin Wan |
| author_sort | Pijun Yan |
| collection | DOAJ |
| description | ObjectiveDespite previous research that focused on aspartate aminotransferase/alanine aminotransferase ratio (AAR) as predictors of type 2 diabetes mellitus (T2DM) and cardiovascular disease, there has been limited research evaluating the association between AAR and diabetic microvascular complications. This study aimed to investigate the association of AAR with diabetic peripheral neuropathy (DPN).MethodsA total of 1562 hospitalized patients with T2DM were divided into four groups according to AAR quartiles. The relationship between AAR and DPN and related parameters was explored by the Spearman correlation coefficients, multivariable logistic regression analysis, and receiver operating characteristic (ROC) curves.ResultsPatients with higher AAR quartiles had higher levels of vibration perception threshold (VPT) and presence of DPN, and AAR was positively associated with VPT and presence of DPN independent of sex, age, body mass index, and diabetic duration (P<0.01 or P<0.05). Moreover, AAR remained significantly associated with a higher odds ratio (OR) of DPN (OR 2.413, 95% confidence interval [CI] 1.081-5.386, P<0.05) after multivariate adjustment. Additionally, the risk of presence of DPN increased progressively as AAR quartiles increased (all P for trend <0.01) in both male and female subjects, and the highest quartile of AAR of male and female subjects was respectively associated with 107.3% (95% CI: 1.386-3.101; P<0.01) and 136.8% (95% CI: 1.550-3.618; P<0.01) increased odds of DPN compared with the lower quartiles. Last, the analysis of receiver operating characteristic curves revealed that the best cutoff values for AAR to predict the presence of DPN were 0.906 (sensitivity: 70.3%; specificity: 49.2%; and area under the curve [AUC]: 0.618) and 1.402 (sensitivity: 38%; specificity: 81.9%; and AUC: 0.600) in male and female subjects, respectively.ConclusionsThese findings suggest that the high AAR may be associated with the presence of DPN in Chinese patients with T2DM, and may be used as an additional indicator of risk of DPN. |
| first_indexed | 2024-04-10T07:25:34Z |
| format | Article |
| id | doaj.art-d2daff2e3ec34f42a3d75a117119a2db |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T07:25:34Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d2daff2e3ec34f42a3d75a117119a2db2023-02-24T07:46:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.10641251064125Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional studyPijun Yan0Pijun Yan1Pijun Yan2Pijun Yan3Yuru Wu4Yuru Wu5Yuru Wu6Yuru Wu7Xiaofang Dan8Xiaofang Dan9Xiaofang Dan10Xiaofang Dan11Xian Wu12Xian Wu13Xian Wu14Xian Wu15Qian Tang16Qian Tang17Qian Tang18Qian Tang19Xiping Chen20Yong Xu21Yong Xu22Yong Xu23Yong Xu24Jianhua Zhu25Jianhua Zhu26Jianhua Zhu27Jianhua Zhu28Ying Miao29Ying Miao30Ying Miao31Ying Miao32Qin Wan33Qin Wan34Qin Wan35Qin Wan36Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaSouthwest Medical University, Luzhou, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaObjectiveDespite previous research that focused on aspartate aminotransferase/alanine aminotransferase ratio (AAR) as predictors of type 2 diabetes mellitus (T2DM) and cardiovascular disease, there has been limited research evaluating the association between AAR and diabetic microvascular complications. This study aimed to investigate the association of AAR with diabetic peripheral neuropathy (DPN).MethodsA total of 1562 hospitalized patients with T2DM were divided into four groups according to AAR quartiles. The relationship between AAR and DPN and related parameters was explored by the Spearman correlation coefficients, multivariable logistic regression analysis, and receiver operating characteristic (ROC) curves.ResultsPatients with higher AAR quartiles had higher levels of vibration perception threshold (VPT) and presence of DPN, and AAR was positively associated with VPT and presence of DPN independent of sex, age, body mass index, and diabetic duration (P<0.01 or P<0.05). Moreover, AAR remained significantly associated with a higher odds ratio (OR) of DPN (OR 2.413, 95% confidence interval [CI] 1.081-5.386, P<0.05) after multivariate adjustment. Additionally, the risk of presence of DPN increased progressively as AAR quartiles increased (all P for trend <0.01) in both male and female subjects, and the highest quartile of AAR of male and female subjects was respectively associated with 107.3% (95% CI: 1.386-3.101; P<0.01) and 136.8% (95% CI: 1.550-3.618; P<0.01) increased odds of DPN compared with the lower quartiles. Last, the analysis of receiver operating characteristic curves revealed that the best cutoff values for AAR to predict the presence of DPN were 0.906 (sensitivity: 70.3%; specificity: 49.2%; and area under the curve [AUC]: 0.618) and 1.402 (sensitivity: 38%; specificity: 81.9%; and AUC: 0.600) in male and female subjects, respectively.ConclusionsThese findings suggest that the high AAR may be associated with the presence of DPN in Chinese patients with T2DM, and may be used as an additional indicator of risk of DPN.https://www.frontiersin.org/articles/10.3389/fendo.2023.1064125/fullaspartate aminotransferase/alanine aminotransferase ratiodiabetic peripheral neuropathyvibration perception thresholdtype 2 diabetes mellitusChinese population |
| spellingShingle | Pijun Yan Pijun Yan Pijun Yan Pijun Yan Yuru Wu Yuru Wu Yuru Wu Yuru Wu Xiaofang Dan Xiaofang Dan Xiaofang Dan Xiaofang Dan Xian Wu Xian Wu Xian Wu Xian Wu Qian Tang Qian Tang Qian Tang Qian Tang Xiping Chen Yong Xu Yong Xu Yong Xu Yong Xu Jianhua Zhu Jianhua Zhu Jianhua Zhu Jianhua Zhu Ying Miao Ying Miao Ying Miao Ying Miao Qin Wan Qin Wan Qin Wan Qin Wan Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional study Frontiers in Endocrinology aspartate aminotransferase/alanine aminotransferase ratio diabetic peripheral neuropathy vibration perception threshold type 2 diabetes mellitus Chinese population |
| title | Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional study |
| title_full | Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional study |
| title_fullStr | Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional study |
| title_full_unstemmed | Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional study |
| title_short | Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional study |
| title_sort | aspartate aminotransferase alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a chinese population a cross sectional study |
| topic | aspartate aminotransferase/alanine aminotransferase ratio diabetic peripheral neuropathy vibration perception threshold type 2 diabetes mellitus Chinese population |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1064125/full |
| work_keys_str_mv | AT pijunyan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT pijunyan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT pijunyan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT pijunyan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yuruwu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yuruwu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yuruwu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yuruwu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT xiaofangdan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT xiaofangdan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT xiaofangdan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT xiaofangdan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT xianwu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT xianwu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT xianwu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT xianwu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT qiantang aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT qiantang aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT qiantang aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT qiantang aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT xipingchen aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yongxu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yongxu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yongxu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yongxu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT jianhuazhu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT jianhuazhu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT jianhuazhu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT jianhuazhu aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yingmiao aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yingmiao aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yingmiao aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT yingmiao aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT qinwan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT qinwan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT qinwan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy AT qinwan aspartateaminotransferasealanineaminotransferaseratiowasassociatedwithtype2diabeticperipheralneuropathyinachinesepopulationacrosssectionalstudy |