Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degeneration
Age-related macular degeneration(AMD)is a common eye disease causing irreversible visual impairment in the elderly. The tight junction(TJ)between retinal pigment epithelium cells(RPECs)is an important structural unit of the outer blood retinal barrier(oBRB). The TJ is defective in the pathogenesis o...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2023-02-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/2/202302010.pdf |
| _version_ | 1811173502465605632 |
|---|---|
| author | Qiao-Yun Wang Lai-Qing Xie |
| author_facet | Qiao-Yun Wang Lai-Qing Xie |
| author_sort | Qiao-Yun Wang |
| collection | DOAJ |
| description | Age-related macular degeneration(AMD)is a common eye disease causing irreversible visual impairment in the elderly. The tight junction(TJ)between retinal pigment epithelium cells(RPECs)is an important structural unit of the outer blood retinal barrier(oBRB). The TJ is defective in the pathogenesis of AMD, which in turn promotes the destruction of oBRB and accelerates the occurrence and progression of AMD. In this paper, the roles of TJ and TJ protein in maintaining oBRB function, TJ protein abnormality and oBRB destruction in the pathogenesis of AMD were reviewed, aiming to provide new ideas for the treatment of AMD. |
| first_indexed | 2024-04-10T17:49:06Z |
| format | Article |
| id | doaj.art-d2db36e73ef84239bc20949d48f0b463 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-10T17:49:06Z |
| publishDate | 2023-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-d2db36e73ef84239bc20949d48f0b4632023-02-03T03:16:21ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-02-0123223223510.3980/j.issn.1672-5123.2023.2.10202302010Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degenerationQiao-Yun Wang0Lai-Qing Xie1Department of Ophthalmology,the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, ChinaAge-related macular degeneration(AMD)is a common eye disease causing irreversible visual impairment in the elderly. The tight junction(TJ)between retinal pigment epithelium cells(RPECs)is an important structural unit of the outer blood retinal barrier(oBRB). The TJ is defective in the pathogenesis of AMD, which in turn promotes the destruction of oBRB and accelerates the occurrence and progression of AMD. In this paper, the roles of TJ and TJ protein in maintaining oBRB function, TJ protein abnormality and oBRB destruction in the pathogenesis of AMD were reviewed, aiming to provide new ideas for the treatment of AMD.http://ies.ijo.cn/cn_publish/2023/2/202302010.pdfage-related macular degeneration(amd)outer blood retinal barrierretinal pigment epitheliumtight junction |
| spellingShingle | Qiao-Yun Wang Lai-Qing Xie Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degeneration Guoji Yanke Zazhi age-related macular degeneration(amd) outer blood retinal barrier retinal pigment epithelium tight junction |
| title | Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degeneration |
| title_full | Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degeneration |
| title_fullStr | Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degeneration |
| title_full_unstemmed | Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degeneration |
| title_short | Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degeneration |
| title_sort | research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age related macular degeneration |
| topic | age-related macular degeneration(amd) outer blood retinal barrier retinal pigment epithelium tight junction |
| url | http://ies.ijo.cn/cn_publish/2023/2/202302010.pdf |
| work_keys_str_mv | AT qiaoyunwang researchprogressoftightjunctionbetweenretinalpigmentepitheliumcellsanditsdisruptioninthepathogenesisofagerelatedmaculardegeneration AT laiqingxie researchprogressoftightjunctionbetweenretinalpigmentepitheliumcellsanditsdisruptioninthepathogenesisofagerelatedmaculardegeneration |