Fucoxanthin—An Antibacterial Carotenoid
Fucoxanthin is a carotenoid produced by brown algae and diatoms. This compound has several biological properties such as antioxidant, anti-obesity, anti-diabetic, anticancer, and antimicrobial activities. Unfortunately, until now the latter effect has been poorly confirmed. The aim of this study was...
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| Format: | Article |
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MDPI AG
2019-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/8/239 |
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| author | Tomasz M. Karpiński Artur Adamczak |
| author_facet | Tomasz M. Karpiński Artur Adamczak |
| author_sort | Tomasz M. Karpiński |
| collection | DOAJ |
| description | Fucoxanthin is a carotenoid produced by brown algae and diatoms. This compound has several biological properties such as antioxidant, anti-obesity, anti-diabetic, anticancer, and antimicrobial activities. Unfortunately, until now the latter effect has been poorly confirmed. The aim of this study was an evaluation of fucoxanthin activity against 20 bacterial species. Antimicrobial effect of fucoxanthin was determined by using the agar disc-diffusion and micro-dilution methods. The studied carotenoid acted against 13 bacteria growing in aerobic conditions. It was observed to have a significantly stronger impact on Gram-positive than Gram-negative bacteria. Mean zones of growth inhibition (ZOIs) for Gram-positive bacteria ranged between 9.0 and 12.2 mm, while for Gram-negative were from 7.2 to 10.2 mm. According to the agar disc-diffusion method, the highest activity of fucoxanthin was exhibited against <i>Streptococcus agalactiae</i> (mean ZOI 12.2 mm), <i>Staphylococcus epidermidis</i> (mean ZOI 11.2 mm), and <i>Staphylococcus aureus</i> (mean ZOI 11.0 mm), and in the microdilution test towards <i>Streptococcus agalactiae</i> with the minimal inhibitory concentration (MIC) of 62.5 µg/mL. On the other hand, fucoxanthin was not active against strict anaerobic bacteria. |
| first_indexed | 2024-03-12T09:01:14Z |
| format | Article |
| id | doaj.art-d2dbd12e7d4a4929977cbe91913d0d62 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T09:01:14Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-d2dbd12e7d4a4929977cbe91913d0d622023-09-02T15:40:29ZengMDPI AGAntioxidants2076-39212019-07-018823910.3390/antiox8080239antiox8080239Fucoxanthin—An Antibacterial CarotenoidTomasz M. Karpiński0Artur Adamczak1Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, PolandDepartment of Botany, Breeding and Agricultural Technology of Medicinal Plants, Institute of Natural Fibres and Medicinal Plants, Kolejowa 2, 62-064 Plewiska, PolandFucoxanthin is a carotenoid produced by brown algae and diatoms. This compound has several biological properties such as antioxidant, anti-obesity, anti-diabetic, anticancer, and antimicrobial activities. Unfortunately, until now the latter effect has been poorly confirmed. The aim of this study was an evaluation of fucoxanthin activity against 20 bacterial species. Antimicrobial effect of fucoxanthin was determined by using the agar disc-diffusion and micro-dilution methods. The studied carotenoid acted against 13 bacteria growing in aerobic conditions. It was observed to have a significantly stronger impact on Gram-positive than Gram-negative bacteria. Mean zones of growth inhibition (ZOIs) for Gram-positive bacteria ranged between 9.0 and 12.2 mm, while for Gram-negative were from 7.2 to 10.2 mm. According to the agar disc-diffusion method, the highest activity of fucoxanthin was exhibited against <i>Streptococcus agalactiae</i> (mean ZOI 12.2 mm), <i>Staphylococcus epidermidis</i> (mean ZOI 11.2 mm), and <i>Staphylococcus aureus</i> (mean ZOI 11.0 mm), and in the microdilution test towards <i>Streptococcus agalactiae</i> with the minimal inhibitory concentration (MIC) of 62.5 µg/mL. On the other hand, fucoxanthin was not active against strict anaerobic bacteria.https://www.mdpi.com/2076-3921/8/8/239brown seaweedsalgal pigmentsantibacterial activitydisk-diffusion methodmicro-dilution method |
| spellingShingle | Tomasz M. Karpiński Artur Adamczak Fucoxanthin—An Antibacterial Carotenoid Antioxidants brown seaweeds algal pigments antibacterial activity disk-diffusion method micro-dilution method |
| title | Fucoxanthin—An Antibacterial Carotenoid |
| title_full | Fucoxanthin—An Antibacterial Carotenoid |
| title_fullStr | Fucoxanthin—An Antibacterial Carotenoid |
| title_full_unstemmed | Fucoxanthin—An Antibacterial Carotenoid |
| title_short | Fucoxanthin—An Antibacterial Carotenoid |
| title_sort | fucoxanthin an antibacterial carotenoid |
| topic | brown seaweeds algal pigments antibacterial activity disk-diffusion method micro-dilution method |
| url | https://www.mdpi.com/2076-3921/8/8/239 |
| work_keys_str_mv | AT tomaszmkarpinski fucoxanthinanantibacterialcarotenoid AT arturadamczak fucoxanthinanantibacterialcarotenoid |