Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota
Abstract Rape (Brassica napus L.) bee pollen (RBP) is a functional food rich in nutrients obtained by worker bees collecting rape pollen and mixing it with nectar and bee salivary enzymes. The study aimed to investigate the protective impact of RBP on renal tissue damage and modulating gut microbiot...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | eFood |
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| Online Access: | https://doi.org/10.1002/efd2.101 |
| _version_ | 1797743814565167104 |
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| author | Yingjun Hu Simin Chen Wenrui Yan Le Ji Mengli Shao Ze Sun Dong He Lijun Zhang Zengrun Xia Xinsheng Li Hongxing Zheng Shanshan Qi |
| author_facet | Yingjun Hu Simin Chen Wenrui Yan Le Ji Mengli Shao Ze Sun Dong He Lijun Zhang Zengrun Xia Xinsheng Li Hongxing Zheng Shanshan Qi |
| author_sort | Yingjun Hu |
| collection | DOAJ |
| description | Abstract Rape (Brassica napus L.) bee pollen (RBP) is a functional food rich in nutrients obtained by worker bees collecting rape pollen and mixing it with nectar and bee salivary enzymes. The study aimed to investigate the protective impact of RBP on renal tissue damage and modulating gut microbiota in diabetic rats. We established a diabetic model of rat via streptozotocin injection, then the rats were treated with RBP for 6 weeks. Results showed that RBP significantly suppressed fasting glucose, reduced oxidative stress and prevented renal pathological changes as well as renal function damage in diabetic rats. In addition, RBP reduced the levels of serum inflammatory cytokines (tumor necrosis factor‐α, monocyte chemoattractant protein‐1, C‐reaction protein, interleukin (IL)‐6, IL‐1β, and IL‐18), and the expression levels of transforming growth factor‐β1, p‐Smad2, and p‐Smad3 in the kidney. Moreover, RBP supplementation also improved the gut microbial dysregulation in diabetic rats. Based on the results, RBP can improve kidney tissue damage in diabetic rats. This study will promote the development of RBP functional food. |
| first_indexed | 2024-03-12T15:00:53Z |
| format | Article |
| id | doaj.art-d2dca6b7743042f3b693e90b899f874a |
| institution | Directory Open Access Journal |
| issn | 2666-3066 |
| language | English |
| last_indexed | 2024-03-12T15:00:53Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | eFood |
| spelling | doaj.art-d2dca6b7743042f3b693e90b899f874a2023-08-14T08:22:27ZengWileyeFood2666-30662023-08-0144n/an/a10.1002/efd2.101Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiotaYingjun Hu0Simin Chen1Wenrui Yan2Le Ji3Mengli Shao4Ze Sun5Dong He6Lijun Zhang7Zengrun Xia8Xinsheng Li9Hongxing Zheng10Shanshan Qi11School of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaSchool of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaSchool of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaSchool of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaSchool of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaSchool of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaSchool of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaChina Selenium Rich Industry Research Institute Ankang Shaanxi ChinaChina Selenium Rich Industry Research Institute Ankang Shaanxi ChinaSchool of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaSchool of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaSchool of Biological Science and Engineering Shaanxi University of Technology Hanzhong Shaanxi ChinaAbstract Rape (Brassica napus L.) bee pollen (RBP) is a functional food rich in nutrients obtained by worker bees collecting rape pollen and mixing it with nectar and bee salivary enzymes. The study aimed to investigate the protective impact of RBP on renal tissue damage and modulating gut microbiota in diabetic rats. We established a diabetic model of rat via streptozotocin injection, then the rats were treated with RBP for 6 weeks. Results showed that RBP significantly suppressed fasting glucose, reduced oxidative stress and prevented renal pathological changes as well as renal function damage in diabetic rats. In addition, RBP reduced the levels of serum inflammatory cytokines (tumor necrosis factor‐α, monocyte chemoattractant protein‐1, C‐reaction protein, interleukin (IL)‐6, IL‐1β, and IL‐18), and the expression levels of transforming growth factor‐β1, p‐Smad2, and p‐Smad3 in the kidney. Moreover, RBP supplementation also improved the gut microbial dysregulation in diabetic rats. Based on the results, RBP can improve kidney tissue damage in diabetic rats. This study will promote the development of RBP functional food.https://doi.org/10.1002/efd2.101anti‐inflammationdiabetic nephropathygut microbialrape bee pollenTGF‐β1/Smad pathway |
| spellingShingle | Yingjun Hu Simin Chen Wenrui Yan Le Ji Mengli Shao Ze Sun Dong He Lijun Zhang Zengrun Xia Xinsheng Li Hongxing Zheng Shanshan Qi Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota eFood anti‐inflammation diabetic nephropathy gut microbial rape bee pollen TGF‐β1/Smad pathway |
| title | Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota |
| title_full | Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota |
| title_fullStr | Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota |
| title_full_unstemmed | Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota |
| title_short | Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota |
| title_sort | rape bee pollen alleviates renal tissue damage in diabetic rats via anti inflammation anti oxidation and modulating gut microbiota |
| topic | anti‐inflammation diabetic nephropathy gut microbial rape bee pollen TGF‐β1/Smad pathway |
| url | https://doi.org/10.1002/efd2.101 |
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