Visceral leishmaniasis treatment outcome and its determinants in northwest Ethiopia
OBJECTIVES Poor treatment outcomes of visceral leishmaniasis (VL) are responsible for the high mortality rate of this condition in resource-limited settings such as Ethiopia. This study aimed to identify the proportion of poor VL treatment outcomes in northwest Ethiopia and to evaluate the determina...
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| Format: | Article |
| Language: | English |
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Korean Society of Epidemiology
2016-12-01
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| Series: | Epidemiology and Health |
| Subjects: | |
| Online Access: | http://www.e-epih.org/upload/pdf/epih-39-e2017001.pdf |
| _version_ | 1818481657064194048 |
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| author | Getachew Mebrahtu Welay Kefyalew Addis Alene Berihun Assefa Dachew |
| author_facet | Getachew Mebrahtu Welay Kefyalew Addis Alene Berihun Assefa Dachew |
| author_sort | Getachew Mebrahtu Welay |
| collection | DOAJ |
| description | OBJECTIVES Poor treatment outcomes of visceral leishmaniasis (VL) are responsible for the high mortality rate of this condition in resource-limited settings such as Ethiopia. This study aimed to identify the proportion of poor VL treatment outcomes in northwest Ethiopia and to evaluate the determinants associated with poor outcomes. METHODS A hospital-based retrospective study was conducted among 595 VL patients who were admitted to Kahsay Abera Hospital in northwest Ethiopia from October 2010 to April 2013. Data were entered into Epi Info version 7.0 and exported to SPSS version 20 for analysis. Bivariate and multivariate logistic regression models were fitted to identify the determinants of VL treatment outcomes. Adjusted odds ratio (aORs) with 95% confidence intervals (CIs) were used, and p-values <0.05 were considered to indicate statistical significance. RESULTS The proportion of poor treatment outcomes was 23.7%. Late diagnosis (≥29 days) (aOR, 4.34; 95% CI, 2.22 to 8.46), severe illness at admission (inability to walk) (aOR, 1.63; 95% CI, 1.06 to 2.40) and coinfection with VL and human immunodeficiency virus (HIV) (aOR, 2.72; 95% CI, 1.40 to 5.20) were found to be determinants of poor VL treatment outcomes. CONCLUSIONS Poor treatment outcomes, such as death, treatment failure, and non-adherence, were found to be common. Special attention must be paid to severely ill and VL/HIV-coinfected patients. To improve VL treatment outcomes, the early diagnosis and treatment of VL patients is recommended. |
| first_indexed | 2024-12-10T11:37:51Z |
| format | Article |
| id | doaj.art-d2dcf09749af4d5ab3767637b2caff4b |
| institution | Directory Open Access Journal |
| issn | 2092-7193 |
| language | English |
| last_indexed | 2024-12-10T11:37:51Z |
| publishDate | 2016-12-01 |
| publisher | Korean Society of Epidemiology |
| record_format | Article |
| series | Epidemiology and Health |
| spelling | doaj.art-d2dcf09749af4d5ab3767637b2caff4b2022-12-22T01:50:22ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932016-12-013910.4178/epih.e2017001886Visceral leishmaniasis treatment outcome and its determinants in northwest EthiopiaGetachew Mebrahtu Welay0Kefyalew Addis Alene1Berihun Assefa Dachew2 Aksum University, Shire Campus, Shire, Ethiopia Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaOBJECTIVES Poor treatment outcomes of visceral leishmaniasis (VL) are responsible for the high mortality rate of this condition in resource-limited settings such as Ethiopia. This study aimed to identify the proportion of poor VL treatment outcomes in northwest Ethiopia and to evaluate the determinants associated with poor outcomes. METHODS A hospital-based retrospective study was conducted among 595 VL patients who were admitted to Kahsay Abera Hospital in northwest Ethiopia from October 2010 to April 2013. Data were entered into Epi Info version 7.0 and exported to SPSS version 20 for analysis. Bivariate and multivariate logistic regression models were fitted to identify the determinants of VL treatment outcomes. Adjusted odds ratio (aORs) with 95% confidence intervals (CIs) were used, and p-values <0.05 were considered to indicate statistical significance. RESULTS The proportion of poor treatment outcomes was 23.7%. Late diagnosis (≥29 days) (aOR, 4.34; 95% CI, 2.22 to 8.46), severe illness at admission (inability to walk) (aOR, 1.63; 95% CI, 1.06 to 2.40) and coinfection with VL and human immunodeficiency virus (HIV) (aOR, 2.72; 95% CI, 1.40 to 5.20) were found to be determinants of poor VL treatment outcomes. CONCLUSIONS Poor treatment outcomes, such as death, treatment failure, and non-adherence, were found to be common. Special attention must be paid to severely ill and VL/HIV-coinfected patients. To improve VL treatment outcomes, the early diagnosis and treatment of VL patients is recommended.http://www.e-epih.org/upload/pdf/epih-39-e2017001.pdfVisceral leishmaniasisTreatment outcomeDeterminantsEthiopia |
| spellingShingle | Getachew Mebrahtu Welay Kefyalew Addis Alene Berihun Assefa Dachew Visceral leishmaniasis treatment outcome and its determinants in northwest Ethiopia Epidemiology and Health Visceral leishmaniasis Treatment outcome Determinants Ethiopia |
| title | Visceral leishmaniasis treatment outcome and its determinants in northwest Ethiopia |
| title_full | Visceral leishmaniasis treatment outcome and its determinants in northwest Ethiopia |
| title_fullStr | Visceral leishmaniasis treatment outcome and its determinants in northwest Ethiopia |
| title_full_unstemmed | Visceral leishmaniasis treatment outcome and its determinants in northwest Ethiopia |
| title_short | Visceral leishmaniasis treatment outcome and its determinants in northwest Ethiopia |
| title_sort | visceral leishmaniasis treatment outcome and its determinants in northwest ethiopia |
| topic | Visceral leishmaniasis Treatment outcome Determinants Ethiopia |
| url | http://www.e-epih.org/upload/pdf/epih-39-e2017001.pdf |
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