Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women
Abstract Background The aim of this study is to determine whether there is correlation between endothelial function and skeletal muscle function measured by hand grip strength in elderly women. Methods This cross‐sectional study used data of NAMGARAM‐2 cohort. The NAMGARAM‐2 cohort consisted of a gr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-12-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.12340 |
| _version_ | 1797205036617433088 |
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| author | Jun‐Il Yoo Mi‐Ji Kim Jae‐Bum Na Yun‐Hong Chun Young‐Jin Park Yongwhi Park Young‐Sool Hah Yong‐Chan Ha Ki Soo Park |
| author_facet | Jun‐Il Yoo Mi‐Ji Kim Jae‐Bum Na Yun‐Hong Chun Young‐Jin Park Yongwhi Park Young‐Sool Hah Yong‐Chan Ha Ki Soo Park |
| author_sort | Jun‐Il Yoo |
| collection | DOAJ |
| description | Abstract Background The aim of this study is to determine whether there is correlation between endothelial function and skeletal muscle function measured by hand grip strength in elderly women. Methods This cross‐sectional study used data of NAMGARAM‐2 cohort. The NAMGARAM‐2 cohort consisted of a group of people living in three rural communities. They were enrolled for studies on activity limitation due to age‐related musculoskeletal disorders including knee osteoarthritis, osteoporosis, and sarcopenia. They were residents aged 40 years or older. They agreed to participate in this cohort from March 2016 to May 2017. Peripheral endothelial function was assessed by reactive hyperaemia‐peripheral arterial tonometry using EndoPAT2000 system. Hand grip strength was measured using a digital hand dynamometer. Results Endothelial function index assessed by EndoPAT was worse in the low grip strength group than that in the normal group of elderly women (1.54 ± 0.51 in the low grip strength group vs. 1.77 ± 0.67 in the normal group, P = 0.003). There was a positive correlation between hand grip strength and endothelial function (r = 0.176, P = 0.007). On stepwise multivariate analysis, endothelial dysfunction (reactive hyperaemia‐peripheral arterial tonometry index < 1.67) significantly increased the risk of low hand grip strength (odds ratio = 2.019; 95% confidence interval = 1.107–3.682; P = 0.022). Conclusions Endothelial function and skeletal muscle strength had a significant correlation in elderly women, providing additional support for the relevant role of vascular system in sarcopenia. |
| first_indexed | 2024-04-24T08:44:44Z |
| format | Article |
| id | doaj.art-d2dd8dce10df4f5fad06c711c8f773d5 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-24T08:44:44Z |
| publishDate | 2018-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-d2dd8dce10df4f5fad06c711c8f773d52024-04-16T14:06:32ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092018-12-01961034104110.1002/jcsm.12340Relationship between endothelial function and skeletal muscle strength in community dwelling elderly womenJun‐Il Yoo0Mi‐Ji Kim1Jae‐Bum Na2Yun‐Hong Chun3Young‐Jin Park4Yongwhi Park5Young‐Sool Hah6Yong‐Chan Ha7Ki Soo Park8Department of Orthopedic Surgery Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju South KoreaDepartment of Preventive Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju South KoreaDepartment of Radiology Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju South KoreaDepartment of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju South KoreaDepartment of Orthopedic Surgery Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju South KoreaDepartment of Internal Medicine Gyeongsang National University Changwon Hospital Changwon South KoreaInstitute of Health Sciences Gyeongsang National University Jinju South KoreaDepartment of Orthopedic Surgery Chung‐Ang University Hospital Seoul South KoreaDepartment of Preventive Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju South KoreaAbstract Background The aim of this study is to determine whether there is correlation between endothelial function and skeletal muscle function measured by hand grip strength in elderly women. Methods This cross‐sectional study used data of NAMGARAM‐2 cohort. The NAMGARAM‐2 cohort consisted of a group of people living in three rural communities. They were enrolled for studies on activity limitation due to age‐related musculoskeletal disorders including knee osteoarthritis, osteoporosis, and sarcopenia. They were residents aged 40 years or older. They agreed to participate in this cohort from March 2016 to May 2017. Peripheral endothelial function was assessed by reactive hyperaemia‐peripheral arterial tonometry using EndoPAT2000 system. Hand grip strength was measured using a digital hand dynamometer. Results Endothelial function index assessed by EndoPAT was worse in the low grip strength group than that in the normal group of elderly women (1.54 ± 0.51 in the low grip strength group vs. 1.77 ± 0.67 in the normal group, P = 0.003). There was a positive correlation between hand grip strength and endothelial function (r = 0.176, P = 0.007). On stepwise multivariate analysis, endothelial dysfunction (reactive hyperaemia‐peripheral arterial tonometry index < 1.67) significantly increased the risk of low hand grip strength (odds ratio = 2.019; 95% confidence interval = 1.107–3.682; P = 0.022). Conclusions Endothelial function and skeletal muscle strength had a significant correlation in elderly women, providing additional support for the relevant role of vascular system in sarcopenia.https://doi.org/10.1002/jcsm.12340SarcopeniaEndothelial functionEndoPAT |
| spellingShingle | Jun‐Il Yoo Mi‐Ji Kim Jae‐Bum Na Yun‐Hong Chun Young‐Jin Park Yongwhi Park Young‐Sool Hah Yong‐Chan Ha Ki Soo Park Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women Journal of Cachexia, Sarcopenia and Muscle Sarcopenia Endothelial function EndoPAT |
| title | Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women |
| title_full | Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women |
| title_fullStr | Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women |
| title_full_unstemmed | Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women |
| title_short | Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women |
| title_sort | relationship between endothelial function and skeletal muscle strength in community dwelling elderly women |
| topic | Sarcopenia Endothelial function EndoPAT |
| url | https://doi.org/10.1002/jcsm.12340 |
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