Severely Hypoperfused Brain Tissue Correlates with Final Infarct Volume Despite Recanalization in DMVO Stroke
Objectives: We sought to assess whether there were any parameter(s) on baseline computed-tomography-perfusion (CTP) strongly correlating with final-infarct-volume, and infarct volume progression after endovascular recanalization of acute ischemic stroke (AIS) with primary distal, medium vessel occlu...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ubiquity Press
2023-11-01
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| Series: | Journal of the Belgian Society of Radiology |
| Subjects: | |
| Online Access: | https://account.jbsr.be/index.php/up-j-jbsr/article/view/3269 |
| _version_ | 1797382809144262656 |
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| author | Maud Wang Yousra Farouki Franny Hulscher Benjamin Mine Thomas Bonnet Stephanie Elens Juan Vazquez Suarez Lise Jodaitis Noemie Ligot Gilles Naeije Boris Lubicz Adrien Guenego |
| author_facet | Maud Wang Yousra Farouki Franny Hulscher Benjamin Mine Thomas Bonnet Stephanie Elens Juan Vazquez Suarez Lise Jodaitis Noemie Ligot Gilles Naeije Boris Lubicz Adrien Guenego |
| author_sort | Maud Wang |
| collection | DOAJ |
| description | Objectives: We sought to assess whether there were any parameter(s) on baseline computed-tomography-perfusion (CTP) strongly correlating with final-infarct-volume, and infarct volume progression after endovascular recanalization of acute ischemic stroke (AIS) with primary distal, medium vessel occlusion (DMVO). Materials and Methods: We performed a retrospective analysis of consecutive AIS patients who were successfully recanalized by thrombectomy for DMVO. By comparing baseline CTP and follow-up MRI, we evaluated the correlation between baseline infarct and hypoperfusion volumes, and final infarct volume and infarct volume progression. We also examined their effect on good clinical outcome at 3 months (defined as an mRS score of 0 to 2). Results: Between January 2018 and January 2021, 38 patients met the inclusion criteria (76% [29/38] female, median age 75 [66–86] years). Median final infarct volume and infarct volume progression were 8.4 mL [IQR: 5.2–44.4] and 7.2 mL [IQR: 4.3–29.1] respectively. TMax>10 sec volume was strongly correlated with both (r=0.831 and r=0.771 respectively, p<0.0001), as well as with good clinical outcome (–0.5, p=0.001). A higher baseline TMax>10 sec volume increased the probability of a higher final-infarct-volume (r2=0.690, coefficient = 0.83 [0.64–1.00], p<0.0001), whereas it decreased the probability of good clinical outcome at 3 months (odds ratio = –0.67 [–1.17 to –0.18], p=0.008). Conclusion: TMax>10 sec volume on baseline CTP correlates strongly with final infarct volume as well as with clinical outcome after mechanical thrombectomy for an AIS with DMVO. |
| first_indexed | 2024-03-08T21:10:48Z |
| format | Article |
| id | doaj.art-d2dd8f66639748ac9f45f215398ba394 |
| institution | Directory Open Access Journal |
| issn | 2514-8281 |
| language | English |
| last_indexed | 2024-03-08T21:10:48Z |
| publishDate | 2023-11-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Journal of the Belgian Society of Radiology |
| spelling | doaj.art-d2dd8f66639748ac9f45f215398ba3942023-12-22T06:35:20ZengUbiquity PressJournal of the Belgian Society of Radiology2514-82812023-11-011071909010.5334/jbsr.32693263Severely Hypoperfused Brain Tissue Correlates with Final Infarct Volume Despite Recanalization in DMVO StrokeMaud Wang0https://orcid.org/0000-0003-4216-9958Yousra Farouki1Franny Hulscher2https://orcid.org/0000-0002-2568-1717Benjamin Mine3https://orcid.org/0000-0002-9727-9196Thomas Bonnet4https://orcid.org/0000-0002-3121-6686Stephanie Elens5https://orcid.org/0000-0003-2433-8404Juan Vazquez Suarez6Lise Jodaitis7Noemie Ligot8https://orcid.org/0000-0002-0386-6817Gilles Naeije9https://orcid.org/0000-0003-1580-1970Boris Lubicz10https://orcid.org/0000-0001-8312-2115Adrien Guenego11https://orcid.org/0000-0001-7281-1652Department of Radiology, Leuven University Hospital, Leuven; Department of Interventional Neuroradiology, Erasme University Hospital, BrusselsDepartment of Interventional Neuroradiology, Erasme University Hospital, BrusselsDepartment of Interventional Neuroradiology, Erasme University Hospital, BrusselsDepartment of Interventional Neuroradiology, Erasme University Hospital, BrusselsDepartment of Interventional Neuroradiology, Erasme University Hospital, BrusselsDepartment of Interventional Neuroradiology, Erasme University Hospital, BrusselsDepartment of Interventional Neuroradiology, Erasme University Hospital, BrusselsDepartment of Neurology, Erasme University Hospital, BrusselsDepartment of Neurology, Erasme University Hospital, BrusselsDepartment of Neurology, Erasme University Hospital, BrusselsDepartment of Interventional Neuroradiology, Erasme University Hospital, BrusselsDepartment of Interventional Neuroradiology, Erasme University Hospital, BrusselsObjectives: We sought to assess whether there were any parameter(s) on baseline computed-tomography-perfusion (CTP) strongly correlating with final-infarct-volume, and infarct volume progression after endovascular recanalization of acute ischemic stroke (AIS) with primary distal, medium vessel occlusion (DMVO). Materials and Methods: We performed a retrospective analysis of consecutive AIS patients who were successfully recanalized by thrombectomy for DMVO. By comparing baseline CTP and follow-up MRI, we evaluated the correlation between baseline infarct and hypoperfusion volumes, and final infarct volume and infarct volume progression. We also examined their effect on good clinical outcome at 3 months (defined as an mRS score of 0 to 2). Results: Between January 2018 and January 2021, 38 patients met the inclusion criteria (76% [29/38] female, median age 75 [66–86] years). Median final infarct volume and infarct volume progression were 8.4 mL [IQR: 5.2–44.4] and 7.2 mL [IQR: 4.3–29.1] respectively. TMax>10 sec volume was strongly correlated with both (r=0.831 and r=0.771 respectively, p<0.0001), as well as with good clinical outcome (–0.5, p=0.001). A higher baseline TMax>10 sec volume increased the probability of a higher final-infarct-volume (r2=0.690, coefficient = 0.83 [0.64–1.00], p<0.0001), whereas it decreased the probability of good clinical outcome at 3 months (odds ratio = –0.67 [–1.17 to –0.18], p=0.008). Conclusion: TMax>10 sec volume on baseline CTP correlates strongly with final infarct volume as well as with clinical outcome after mechanical thrombectomy for an AIS with DMVO.https://account.jbsr.be/index.php/up-j-jbsr/article/view/3269acute ischemic strokeendovascular recanalizationdistal thrombectomyperfusion imaging |
| spellingShingle | Maud Wang Yousra Farouki Franny Hulscher Benjamin Mine Thomas Bonnet Stephanie Elens Juan Vazquez Suarez Lise Jodaitis Noemie Ligot Gilles Naeije Boris Lubicz Adrien Guenego Severely Hypoperfused Brain Tissue Correlates with Final Infarct Volume Despite Recanalization in DMVO Stroke Journal of the Belgian Society of Radiology acute ischemic stroke endovascular recanalization distal thrombectomy perfusion imaging |
| title | Severely Hypoperfused Brain Tissue Correlates with Final Infarct Volume Despite Recanalization in DMVO Stroke |
| title_full | Severely Hypoperfused Brain Tissue Correlates with Final Infarct Volume Despite Recanalization in DMVO Stroke |
| title_fullStr | Severely Hypoperfused Brain Tissue Correlates with Final Infarct Volume Despite Recanalization in DMVO Stroke |
| title_full_unstemmed | Severely Hypoperfused Brain Tissue Correlates with Final Infarct Volume Despite Recanalization in DMVO Stroke |
| title_short | Severely Hypoperfused Brain Tissue Correlates with Final Infarct Volume Despite Recanalization in DMVO Stroke |
| title_sort | severely hypoperfused brain tissue correlates with final infarct volume despite recanalization in dmvo stroke |
| topic | acute ischemic stroke endovascular recanalization distal thrombectomy perfusion imaging |
| url | https://account.jbsr.be/index.php/up-j-jbsr/article/view/3269 |
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