Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investig...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2023-05-01
|
| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304222002331 |
| _version_ | 1797697012210073600 |
|---|---|
| author | Yuan Yuan Guoqiang Qiao Jiajiao Zhou Yilu Zhou Yali Li Xia Li Zhenglin Jiang Yihua Wang |
| author_facet | Yuan Yuan Guoqiang Qiao Jiajiao Zhou Yilu Zhou Yali Li Xia Li Zhenglin Jiang Yihua Wang |
| author_sort | Yuan Yuan |
| collection | DOAJ |
| description | Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients, several potential mechanisms of relevance to IPF pathology were identified, including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together, these data support HBO treatment as a viable strategy against pulmonary fibrosis. |
| first_indexed | 2024-03-12T03:34:09Z |
| format | Article |
| id | doaj.art-d2de74c3cc234d07a7cbdf057f73fdbc |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T03:34:09Z |
| publishDate | 2023-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-d2de74c3cc234d07a7cbdf057f73fdbc2023-09-03T13:21:42ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-05-0110310291039Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosisYuan Yuan0Guoqiang Qiao1Jiajiao Zhou2Yilu Zhou3Yali Li4Xia Li5Zhenglin Jiang6Yihua Wang7Department of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, ChinaDepartment of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, ChinaDepartment of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, ChinaBiological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton, SO17 1BJ, United KingdomDepartment of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, ChinaDepartment of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, China; Corresponding author.Department of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, China; Corresponding author.Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom; Corresponding author. Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom.Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients, several potential mechanisms of relevance to IPF pathology were identified, including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together, these data support HBO treatment as a viable strategy against pulmonary fibrosis.http://www.sciencedirect.com/science/article/pii/S2352304222002331Epithelial-mesenchymal transitionHyperbaricoxygenHypoxiaPulmonary fibrosisSystematic analysis |
| spellingShingle | Yuan Yuan Guoqiang Qiao Jiajiao Zhou Yilu Zhou Yali Li Xia Li Zhenglin Jiang Yihua Wang Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis Genes and Diseases Epithelial-mesenchymal transition Hyperbaricoxygen Hypoxia Pulmonary fibrosis Systematic analysis |
| title | Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis |
| title_full | Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis |
| title_fullStr | Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis |
| title_full_unstemmed | Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis |
| title_short | Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis |
| title_sort | integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis |
| topic | Epithelial-mesenchymal transition Hyperbaricoxygen Hypoxia Pulmonary fibrosis Systematic analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2352304222002331 |
| work_keys_str_mv | AT yuanyuan integratedanalysisrevealstheprotectivemechanismandtherapeuticpotentialofhyperbaricoxygenagainstpulmonaryfibrosis AT guoqiangqiao integratedanalysisrevealstheprotectivemechanismandtherapeuticpotentialofhyperbaricoxygenagainstpulmonaryfibrosis AT jiajiaozhou integratedanalysisrevealstheprotectivemechanismandtherapeuticpotentialofhyperbaricoxygenagainstpulmonaryfibrosis AT yiluzhou integratedanalysisrevealstheprotectivemechanismandtherapeuticpotentialofhyperbaricoxygenagainstpulmonaryfibrosis AT yalili integratedanalysisrevealstheprotectivemechanismandtherapeuticpotentialofhyperbaricoxygenagainstpulmonaryfibrosis AT xiali integratedanalysisrevealstheprotectivemechanismandtherapeuticpotentialofhyperbaricoxygenagainstpulmonaryfibrosis AT zhenglinjiang integratedanalysisrevealstheprotectivemechanismandtherapeuticpotentialofhyperbaricoxygenagainstpulmonaryfibrosis AT yihuawang integratedanalysisrevealstheprotectivemechanismandtherapeuticpotentialofhyperbaricoxygenagainstpulmonaryfibrosis |