REASSURED Multiplex Diagnostics: A Critical Review and Forecast
The diagnosis of infectious diseases is ineffective when the diagnostic test does not meet one or more of the necessary standards of affordability, accessibility, and accuracy. The World Health Organization further clarifies these standards with a set of criteria that has the acronym ASSURED (Afford...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/12/2/124 |
| _version_ | 1797482231543889920 |
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| author | Jonas A. Otoo Travis S. Schlappi |
| author_facet | Jonas A. Otoo Travis S. Schlappi |
| author_sort | Jonas A. Otoo |
| collection | DOAJ |
| description | The diagnosis of infectious diseases is ineffective when the diagnostic test does not meet one or more of the necessary standards of affordability, accessibility, and accuracy. The World Health Organization further clarifies these standards with a set of criteria that has the acronym ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment-free and Deliverable to end-users). The advancement of the digital age has led to a revision of the ASSURED criteria to REASSURED: Real-time connectivity, Ease of specimen collection, Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment-free or simple, and Deliverable to end-users. Many diagnostic tests have been developed that aim to satisfy the REASSURED criteria; however, most of them only detect a single target. With the progression of syndromic infections, coinfections and the current antimicrobial resistance challenges, the need for multiplexed diagnostics is now more important than ever. This review summarizes current diagnostic technologies for multiplexed detection and forecasts which methods have promise for detecting multiple targets and meeting all REASSURED criteria. |
| first_indexed | 2024-03-09T22:28:20Z |
| format | Article |
| id | doaj.art-d2df4a8232df4742b6a7b8305459f295 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T22:28:20Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-d2df4a8232df4742b6a7b8305459f2952023-11-23T19:01:43ZengMDPI AGBiosensors2079-63742022-02-0112212410.3390/bios12020124REASSURED Multiplex Diagnostics: A Critical Review and ForecastJonas A. Otoo0Travis S. Schlappi1Keck Graduate Institute, Claremont, CA 91711, USAKeck Graduate Institute, Claremont, CA 91711, USAThe diagnosis of infectious diseases is ineffective when the diagnostic test does not meet one or more of the necessary standards of affordability, accessibility, and accuracy. The World Health Organization further clarifies these standards with a set of criteria that has the acronym ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment-free and Deliverable to end-users). The advancement of the digital age has led to a revision of the ASSURED criteria to REASSURED: Real-time connectivity, Ease of specimen collection, Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment-free or simple, and Deliverable to end-users. Many diagnostic tests have been developed that aim to satisfy the REASSURED criteria; however, most of them only detect a single target. With the progression of syndromic infections, coinfections and the current antimicrobial resistance challenges, the need for multiplexed diagnostics is now more important than ever. This review summarizes current diagnostic technologies for multiplexed detection and forecasts which methods have promise for detecting multiple targets and meeting all REASSURED criteria.https://www.mdpi.com/2079-6374/12/2/124diagnosticsmultiplexpoint-of-care diagnosticsREASSURED |
| spellingShingle | Jonas A. Otoo Travis S. Schlappi REASSURED Multiplex Diagnostics: A Critical Review and Forecast Biosensors diagnostics multiplex point-of-care diagnostics REASSURED |
| title | REASSURED Multiplex Diagnostics: A Critical Review and Forecast |
| title_full | REASSURED Multiplex Diagnostics: A Critical Review and Forecast |
| title_fullStr | REASSURED Multiplex Diagnostics: A Critical Review and Forecast |
| title_full_unstemmed | REASSURED Multiplex Diagnostics: A Critical Review and Forecast |
| title_short | REASSURED Multiplex Diagnostics: A Critical Review and Forecast |
| title_sort | reassured multiplex diagnostics a critical review and forecast |
| topic | diagnostics multiplex point-of-care diagnostics REASSURED |
| url | https://www.mdpi.com/2079-6374/12/2/124 |
| work_keys_str_mv | AT jonasaotoo reassuredmultiplexdiagnosticsacriticalreviewandforecast AT travissschlappi reassuredmultiplexdiagnosticsacriticalreviewandforecast |