Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene
Abstract Background Metabolic syndrome (MetS), a cluster of metabolic and cardiovascular risk factors is influenced by environmental, lifestyle, and genetic factors. We explored whether coffee consumption and the rs301 variant of the lipoprotein lipase (LPL) gene are related to MetS. Methods We cond...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-024-00931-7 |
| _version_ | 1797275782377111552 |
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| author | Pao-Chun Hsieh Oswald Ndi Nfor Chuan-Chao Lin Chih-Hsuan Hsiao Yung-Po Liaw |
| author_facet | Pao-Chun Hsieh Oswald Ndi Nfor Chuan-Chao Lin Chih-Hsuan Hsiao Yung-Po Liaw |
| author_sort | Pao-Chun Hsieh |
| collection | DOAJ |
| description | Abstract Background Metabolic syndrome (MetS), a cluster of metabolic and cardiovascular risk factors is influenced by environmental, lifestyle, and genetic factors. We explored whether coffee consumption and the rs301 variant of the lipoprotein lipase (LPL) gene are related to MetS. Methods We conducted multiple logistic regression analyses using data gathered from 9523 subjects in Taiwan Biobank (TWB). Results Our findings indicated that individuals who consumed coffee had a reduced odds ratio (OR) for MetS (0.750 (95% confidence interval [CI] 0.653–0.861) compared to non-coffee drinkers. Additionally, the risk of MetS was lower for individuals with the ‘TC’ and ‘CC’ genotypes of rs301 compared to those with the ‘TT’ genotype. Specifically, the OR for MetS was 0.827 (95% CI 0.721–0.949) for the ‘TC’ genotype and 0.848 (95% CI 0.610–1.177) for the ‘CC’ genotype. We observed an interaction between coffee consumption and the rs301 variant, with a p-value for the interaction of 0.0437. Compared to the reference group (‘no coffee drinking/TT’), the ORs for MetS were 0.836 (95% CI 0.706–0.992) for ‘coffee drinking/TT’, 0.557 (95% CI 0.438–0.707) for ‘coffee drinking/TC’, and 0.544 (95% CI 0.319–0.927) for ‘coffee drinking/CC’. Notably, MetS was not observed in non-coffee drinkers regardless of their rs301 genotype. Conclusion Our findings suggest that rs301 genotypes may protect against MetS in Taiwanese adults who consume coffee compared to non-coffee drinkers. |
| first_indexed | 2024-03-07T15:19:23Z |
| format | Article |
| id | doaj.art-d2df7d97a63e426eb15beb9662e29dc3 |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-03-07T15:19:23Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-d2df7d97a63e426eb15beb9662e29dc32024-03-05T17:45:54ZengBMCNutrition Journal1475-28912024-03-012311610.1186/s12937-024-00931-7Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL genePao-Chun Hsieh0Oswald Ndi Nfor1Chuan-Chao Lin2Chih-Hsuan Hsiao3Yung-Po Liaw4Department of Obstetrics and Gynecology, Chung-Kang Branch, Cheng Ching HospitalDepartment of Public Health, Institute of Public Health, Chung Shan Medical UniversityDepartment of Physical Medicine and Rehabilitation, Chung Shan Medical University HospitalDepartment of Public Health, Institute of Public Health, Chung Shan Medical UniversityDepartment of Public Health, Institute of Public Health, Chung Shan Medical UniversityAbstract Background Metabolic syndrome (MetS), a cluster of metabolic and cardiovascular risk factors is influenced by environmental, lifestyle, and genetic factors. We explored whether coffee consumption and the rs301 variant of the lipoprotein lipase (LPL) gene are related to MetS. Methods We conducted multiple logistic regression analyses using data gathered from 9523 subjects in Taiwan Biobank (TWB). Results Our findings indicated that individuals who consumed coffee had a reduced odds ratio (OR) for MetS (0.750 (95% confidence interval [CI] 0.653–0.861) compared to non-coffee drinkers. Additionally, the risk of MetS was lower for individuals with the ‘TC’ and ‘CC’ genotypes of rs301 compared to those with the ‘TT’ genotype. Specifically, the OR for MetS was 0.827 (95% CI 0.721–0.949) for the ‘TC’ genotype and 0.848 (95% CI 0.610–1.177) for the ‘CC’ genotype. We observed an interaction between coffee consumption and the rs301 variant, with a p-value for the interaction of 0.0437. Compared to the reference group (‘no coffee drinking/TT’), the ORs for MetS were 0.836 (95% CI 0.706–0.992) for ‘coffee drinking/TT’, 0.557 (95% CI 0.438–0.707) for ‘coffee drinking/TC’, and 0.544 (95% CI 0.319–0.927) for ‘coffee drinking/CC’. Notably, MetS was not observed in non-coffee drinkers regardless of their rs301 genotype. Conclusion Our findings suggest that rs301 genotypes may protect against MetS in Taiwanese adults who consume coffee compared to non-coffee drinkers.https://doi.org/10.1186/s12937-024-00931-7Metabolic syndromePolymorphismCoffee |
| spellingShingle | Pao-Chun Hsieh Oswald Ndi Nfor Chuan-Chao Lin Chih-Hsuan Hsiao Yung-Po Liaw Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene Nutrition Journal Metabolic syndrome Polymorphism Coffee |
| title | Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene |
| title_full | Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene |
| title_fullStr | Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene |
| title_full_unstemmed | Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene |
| title_short | Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene |
| title_sort | metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the lpl gene |
| topic | Metabolic syndrome Polymorphism Coffee |
| url | https://doi.org/10.1186/s12937-024-00931-7 |
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