Tear Film and Ocular Surface Changes in Patients Receiving Systemic Isotretinoin
Purpose: Our aim in this study was to assess the ocular surface and tear film changes in acne vulgaris patients receiving systemic isotretinoin. Material and Method: Twenty-two eyes of 22 patients who received oral isotretinoin (roaccutane®, 0.7 mg/kg/day) for nodular acne vulgaris were enrolled...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2013-10-01
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| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.oftalmoloji.org/article_2291/Tear-Film-And-Ocular-Surface-Changes-In-Patients-Receiving-Systemic-Isotretinoin |
| _version_ | 1797913427413303296 |
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| author | Ebru Nevin Çetin Berna Şanlı Ferda Bir Filiz Yaldızkaya Nida Kaçar Volkan Yaylalı |
| author_facet | Ebru Nevin Çetin Berna Şanlı Ferda Bir Filiz Yaldızkaya Nida Kaçar Volkan Yaylalı |
| author_sort | Ebru Nevin Çetin |
| collection | DOAJ |
| description | Purpose: Our aim in this study was to assess the ocular surface and tear film changes in acne vulgaris patients receiving systemic
isotretinoin.
Material and Method: Twenty-two eyes of 22 patients who received oral isotretinoin (roaccutane®, 0.7 mg/kg/day) for nodular acne
vulgaris were enrolled in this prospective study. Tear film break-up time (BUT), Schirmer 1 test scores with anesthesia, ocular surface disease
index (OSDI) scores and conjunctival impression cytology scores were recorded before treatment and at 3- and 6-month visits following the
beginning of treatment.
Results: BUT values decreased and OSDI scores significantly increased at 3 months after treatment (p=0.007 and p=0.018, paired samples
test). Schirmer scores did not significantly change by isotretinoin treatment. Of 9 eyes with impression cytology specimens, 4 revealed normal
conjunctival findings before treatment. At the 3rd month, there was an increase in the scores characterized by decrease of Goblet cells, and at 6
months of treatment, normal conjunctival findings did not exist in any of the patients (p=0.004, Friedman test).
Discussion: Systemic isotretinoin treatment can cause alterations in the tear film and cause dry eye symptoms. (Turk J Ophthalmol 2013;
43: 309-12) |
| first_indexed | 2024-04-10T12:11:46Z |
| format | Article |
| id | doaj.art-d2dfd0c6f6f349f1b489b8ac690a7830 |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T12:11:46Z |
| publishDate | 2013-10-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-d2dfd0c6f6f349f1b489b8ac690a78302023-02-15T16:15:59ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612013-10-0143530931210.4274/tjo.87520Tear Film and Ocular Surface Changes in Patients Receiving Systemic IsotretinoinEbru Nevin Çetin0 Berna Şanlı1Ferda Bir2Filiz Yaldızkaya3Nida Kaçar4Volkan Yaylalı5Pamukkale Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Denizli, TürkiyePamukkale Üniversitesi, Tıp Fakültesi, Dermatoloji Anabilim Dalı, Denizli, TürkiyePamukkale Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Denizli, TürkiyePamukkale Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Denizli, TürkiyePamukkale Üniversitesi, Tıp Fakültesi, Dermatoloji Anabilim Dalı, Denizli, TürkiyePamukkale Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Denizli, TürkiyePurpose: Our aim in this study was to assess the ocular surface and tear film changes in acne vulgaris patients receiving systemic isotretinoin. Material and Method: Twenty-two eyes of 22 patients who received oral isotretinoin (roaccutane®, 0.7 mg/kg/day) for nodular acne vulgaris were enrolled in this prospective study. Tear film break-up time (BUT), Schirmer 1 test scores with anesthesia, ocular surface disease index (OSDI) scores and conjunctival impression cytology scores were recorded before treatment and at 3- and 6-month visits following the beginning of treatment. Results: BUT values decreased and OSDI scores significantly increased at 3 months after treatment (p=0.007 and p=0.018, paired samples test). Schirmer scores did not significantly change by isotretinoin treatment. Of 9 eyes with impression cytology specimens, 4 revealed normal conjunctival findings before treatment. At the 3rd month, there was an increase in the scores characterized by decrease of Goblet cells, and at 6 months of treatment, normal conjunctival findings did not exist in any of the patients (p=0.004, Friedman test). Discussion: Systemic isotretinoin treatment can cause alterations in the tear film and cause dry eye symptoms. (Turk J Ophthalmol 2013; 43: 309-12)http://www.oftalmoloji.org/article_2291/Tear-Film-And-Ocular-Surface-Changes-In-Patients-Receiving-Systemic-IsotretinoinAcne vulgaristear film break-up timeimpression cytologyisotretinoindry eyeSchirmer test |
| spellingShingle | Ebru Nevin Çetin Berna Şanlı Ferda Bir Filiz Yaldızkaya Nida Kaçar Volkan Yaylalı Tear Film and Ocular Surface Changes in Patients Receiving Systemic Isotretinoin Türk Oftalmoloji Dergisi Acne vulgaris tear film break-up time impression cytology isotretinoin dry eye Schirmer test |
| title | Tear Film and Ocular Surface Changes in Patients Receiving Systemic Isotretinoin |
| title_full | Tear Film and Ocular Surface Changes in Patients Receiving Systemic Isotretinoin |
| title_fullStr | Tear Film and Ocular Surface Changes in Patients Receiving Systemic Isotretinoin |
| title_full_unstemmed | Tear Film and Ocular Surface Changes in Patients Receiving Systemic Isotretinoin |
| title_short | Tear Film and Ocular Surface Changes in Patients Receiving Systemic Isotretinoin |
| title_sort | tear film and ocular surface changes in patients receiving systemic isotretinoin |
| topic | Acne vulgaris tear film break-up time impression cytology isotretinoin dry eye Schirmer test |
| url | http://www.oftalmoloji.org/article_2291/Tear-Film-And-Ocular-Surface-Changes-In-Patients-Receiving-Systemic-Isotretinoin |
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