The potential of polygenic scores to improve cost and efficiency of clinical trials
Polygenic scores can identify individuals with high disease risk based on inborn DNA variation. We explore their potential to enrich clinical trials by identifying individuals based on higher risk of disease (‘prognostic enrichment’), or increased probability of benefit (‘predictive enrichment’)....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30675-z |
| _version_ | 1818207844912070656 |
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| author | Akl C. Fahed Anthony A. Philippakis Amit V. Khera |
| author_facet | Akl C. Fahed Anthony A. Philippakis Amit V. Khera |
| author_sort | Akl C. Fahed |
| collection | DOAJ |
| description | Polygenic scores can identify individuals with high disease risk based on inborn DNA variation. We explore their potential to enrich clinical trials by identifying individuals based on higher risk of disease (‘prognostic enrichment’), or increased probability of benefit (‘predictive enrichment’). |
| first_indexed | 2024-12-12T04:35:23Z |
| format | Article |
| id | doaj.art-d2e299e461da4d2d98501322a2cf64c4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T04:35:23Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d2e299e461da4d2d98501322a2cf64c42022-12-22T00:37:59ZengNature PortfolioNature Communications2041-17232022-05-011311410.1038/s41467-022-30675-zThe potential of polygenic scores to improve cost and efficiency of clinical trialsAkl C. Fahed0Anthony A. Philippakis1Amit V. Khera2Division of Cardiology and Center for Genomic Medicine, Massachusetts General HospitalData Sciences Platform, Broad Institute of MIT and HarvardDivision of Cardiology and Center for Genomic Medicine, Massachusetts General HospitalPolygenic scores can identify individuals with high disease risk based on inborn DNA variation. We explore their potential to enrich clinical trials by identifying individuals based on higher risk of disease (‘prognostic enrichment’), or increased probability of benefit (‘predictive enrichment’).https://doi.org/10.1038/s41467-022-30675-z |
| spellingShingle | Akl C. Fahed Anthony A. Philippakis Amit V. Khera The potential of polygenic scores to improve cost and efficiency of clinical trials Nature Communications |
| title | The potential of polygenic scores to improve cost and efficiency of clinical trials |
| title_full | The potential of polygenic scores to improve cost and efficiency of clinical trials |
| title_fullStr | The potential of polygenic scores to improve cost and efficiency of clinical trials |
| title_full_unstemmed | The potential of polygenic scores to improve cost and efficiency of clinical trials |
| title_short | The potential of polygenic scores to improve cost and efficiency of clinical trials |
| title_sort | potential of polygenic scores to improve cost and efficiency of clinical trials |
| url | https://doi.org/10.1038/s41467-022-30675-z |
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