Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task
The hippocampus is a brain area crucial for episodic memory in humans. In contrast, studies in rodents have highlighted its role in spatial learning, supported by the discovery of place cells. Efforts to reconcile these views have found neurons in the rodent hippocampus that respond to non-spatial e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/14321 |
| _version_ | 1797997586477481984 |
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| author | Kevin Q Shan Evgueniy V Lubenov Maria Papadopoulou Athanassios G Siapas |
| author_facet | Kevin Q Shan Evgueniy V Lubenov Maria Papadopoulou Athanassios G Siapas |
| author_sort | Kevin Q Shan |
| collection | DOAJ |
| description | The hippocampus is a brain area crucial for episodic memory in humans. In contrast, studies in rodents have highlighted its role in spatial learning, supported by the discovery of place cells. Efforts to reconcile these views have found neurons in the rodent hippocampus that respond to non-spatial events but have not unequivocally dissociated the spatial and non-spatial influences on these cells. To disentangle these influences, we trained freely moving rats in trace eyeblink conditioning, a hippocampally dependent task in which the animal learns to blink in response to a tone. We show that dorsal CA1 pyramidal neurons are all place cells, and do not respond to the tone when the animal is moving. When the animal is inactive, the apparent tone-evoked responses reflect an arousal-mediated resumption of place-specific firing. These results suggest that one of the main output stages of the hippocampus transmits only spatial information, even in this non-spatial task. |
| first_indexed | 2024-04-11T10:34:59Z |
| format | Article |
| id | doaj.art-d2e4a075d16b4ea39f1b4958423dcc7b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T10:34:59Z |
| publishDate | 2016-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d2e4a075d16b4ea39f1b4958423dcc7b2022-12-22T04:29:20ZengeLife Sciences Publications LtdeLife2050-084X2016-08-01510.7554/eLife.14321Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning taskKevin Q Shan0https://orcid.org/0000-0002-2621-1274Evgueniy V Lubenov1https://orcid.org/0000-0002-1099-944XMaria Papadopoulou2Athanassios G Siapas3https://orcid.org/0000-0001-8837-678XDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesThe hippocampus is a brain area crucial for episodic memory in humans. In contrast, studies in rodents have highlighted its role in spatial learning, supported by the discovery of place cells. Efforts to reconcile these views have found neurons in the rodent hippocampus that respond to non-spatial events but have not unequivocally dissociated the spatial and non-spatial influences on these cells. To disentangle these influences, we trained freely moving rats in trace eyeblink conditioning, a hippocampally dependent task in which the animal learns to blink in response to a tone. We show that dorsal CA1 pyramidal neurons are all place cells, and do not respond to the tone when the animal is moving. When the animal is inactive, the apparent tone-evoked responses reflect an arousal-mediated resumption of place-specific firing. These results suggest that one of the main output stages of the hippocampus transmits only spatial information, even in this non-spatial task.https://elifesciences.org/articles/14321hippocampusdorsal CA1nonspatial learning |
| spellingShingle | Kevin Q Shan Evgueniy V Lubenov Maria Papadopoulou Athanassios G Siapas Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task eLife hippocampus dorsal CA1 nonspatial learning |
| title | Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task |
| title_full | Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task |
| title_fullStr | Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task |
| title_full_unstemmed | Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task |
| title_short | Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task |
| title_sort | spatial tuning and brain state account for dorsal hippocampal ca1 activity in a non spatial learning task |
| topic | hippocampus dorsal CA1 nonspatial learning |
| url | https://elifesciences.org/articles/14321 |
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