Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

Abstract In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines based on 4-(N,N-dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The structure of all synthesized compounds were confirmed by spectral date (FT-IR,...

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Bibliographic Details
Main Authors: Eman M. Sayed, Etify A. Bakhite, Reda Hassanien, Nasser Farhan, Hanan F. Aly, Salma G. Morsy, Nivin A. Hassan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Chemistry
Subjects:
Anticancers
Apoptosis
Cell cycle arrest
CDK2 inhibitor
DHFR inhibitor
Antioxidants
Online Access:https://doi.org/10.1186/s13065-024-01139-w

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