Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
Here, a cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene.
| Váldodahkkit: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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Nature Portfolio
2019-09-01
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| Ráidu: | Nature Communications |
| Liŋkkat: | https://doi.org/10.1038/s41467-019-12256-9 |
| _version_ | 1828971798818979840 |
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| author | Juliana M. Sá Sarah R. Kaslow Roberto R. Moraes Barros Nicholas F. Brazeau Christian M. Parobek Dingyin Tao Rebecca E. Salzman Tyler J. Gibson Soundarapandian Velmurugan Michael A. Krause Viviana Melendez-Muniz Whitney A. Kite Paul K. Han Richard T. Eastman Adam Kim Evan G. Kessler Yonas Abebe Eric R. James Sumana Chakravarty Sachy Orr-Gonzalez Lynn E. Lambert Theresa Engels Marvin L. Thomas Pius S. Fasinu David Serre Robert W. Gwadz Larry Walker Derrick K. DeConti Jianbing Mu Jeffrey A. Bailey B. Kim Lee Sim Stephen L. Hoffman Michael P. Fay Rhoel R. Dinglasan Jonathan J. Juliano Thomas E. Wellems |
| author_facet | Juliana M. Sá Sarah R. Kaslow Roberto R. Moraes Barros Nicholas F. Brazeau Christian M. Parobek Dingyin Tao Rebecca E. Salzman Tyler J. Gibson Soundarapandian Velmurugan Michael A. Krause Viviana Melendez-Muniz Whitney A. Kite Paul K. Han Richard T. Eastman Adam Kim Evan G. Kessler Yonas Abebe Eric R. James Sumana Chakravarty Sachy Orr-Gonzalez Lynn E. Lambert Theresa Engels Marvin L. Thomas Pius S. Fasinu David Serre Robert W. Gwadz Larry Walker Derrick K. DeConti Jianbing Mu Jeffrey A. Bailey B. Kim Lee Sim Stephen L. Hoffman Michael P. Fay Rhoel R. Dinglasan Jonathan J. Juliano Thomas E. Wellems |
| author_sort | Juliana M. Sá |
| collection | DOAJ |
| description | Here, a cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene. |
| first_indexed | 2024-12-14T13:16:54Z |
| format | Article |
| id | doaj.art-d2e5b78b5b7d41ea85f525fdaf910313 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:16:54Z |
| publishDate | 2019-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d2e5b78b5b7d41ea85f525fdaf9103132022-12-21T23:00:03ZengNature PortfolioNature Communications2041-17232019-09-0110111010.1038/s41467-019-12256-9Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic crossJuliana M. Sá0Sarah R. Kaslow1Roberto R. Moraes Barros2Nicholas F. Brazeau3Christian M. Parobek4Dingyin Tao5Rebecca E. Salzman6Tyler J. Gibson7Soundarapandian Velmurugan8Michael A. Krause9Viviana Melendez-Muniz10Whitney A. Kite11Paul K. Han12Richard T. Eastman13Adam Kim14Evan G. Kessler15Yonas Abebe16Eric R. James17Sumana Chakravarty18Sachy Orr-Gonzalez19Lynn E. Lambert20Theresa Engels21Marvin L. Thomas22Pius S. Fasinu23David Serre24Robert W. Gwadz25Larry Walker26Derrick K. DeConti27Jianbing Mu28Jeffrey A. Bailey29B. Kim Lee Sim30Stephen L. Hoffman31Michael P. Fay32Rhoel R. Dinglasan33Jonathan J. Juliano34Thomas E. Wellems35Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaCurriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina at Chapel HillW Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthSanaria Inc.Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInstitute for Genome Sciences, University of Maryland School of MedicineLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthSanaria Inc.Sanaria Inc.Sanaria Inc.Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDivision of Veterinary Resources, Office of Research Services, National Institutes of HealthDivision of Veterinary Resources, Office of Research Services, National Institutes of HealthDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Campbell UniversityInstitute for Genome Sciences, University of Maryland School of MedicineLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Campbell UniversityProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical SchoolLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Campbell UniversitySanaria Inc.Sanaria Inc.Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthW Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public HealthDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthHere, a cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene.https://doi.org/10.1038/s41467-019-12256-9 |
| spellingShingle | Juliana M. Sá Sarah R. Kaslow Roberto R. Moraes Barros Nicholas F. Brazeau Christian M. Parobek Dingyin Tao Rebecca E. Salzman Tyler J. Gibson Soundarapandian Velmurugan Michael A. Krause Viviana Melendez-Muniz Whitney A. Kite Paul K. Han Richard T. Eastman Adam Kim Evan G. Kessler Yonas Abebe Eric R. James Sumana Chakravarty Sachy Orr-Gonzalez Lynn E. Lambert Theresa Engels Marvin L. Thomas Pius S. Fasinu David Serre Robert W. Gwadz Larry Walker Derrick K. DeConti Jianbing Mu Jeffrey A. Bailey B. Kim Lee Sim Stephen L. Hoffman Michael P. Fay Rhoel R. Dinglasan Jonathan J. Juliano Thomas E. Wellems Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross Nature Communications |
| title | Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross |
| title_full | Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross |
| title_fullStr | Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross |
| title_full_unstemmed | Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross |
| title_short | Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross |
| title_sort | plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross |
| url | https://doi.org/10.1038/s41467-019-12256-9 |
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