Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons

Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons

Anti-IgLON5 disease is a progressive neurological disorder associated with autoantibodies against a neuronal cell adhesion molecule, IgLON5. In human postmortem brain tissue, the neurodegeneration and accumulation of hyperphosphorylated tau (p-tau) are found. Whether IgLON5 antibodies induce neurode...

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Bibliographic Details
Main Authors: Matias Ryding, Mattias Gamre, Mette S. Nissen, Anna C. Nilsson, Justyna Okarmus, Anne A. E. Poulsen, Morten Meyer, Morten Blaabjerg
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
autoimmune encephalitis
IgLON5
phosphorylated tau
neurodegeneration
Online Access:https://www.mdpi.com/2073-4409/10/4/837

Internet

https://www.mdpi.com/2073-4409/10/4/837

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