Synaptic rewiring of stress-sensitive neurons by early-life experience: A mechanism for resilience?
Genes and environment interact to influence cognitive and emotional functions throughout life. Early-life experiences in particular contribute to vulnerability or resilience to a number of emotional and cognitive illnesses in humans. In rodents, early-life experiences directly lead to resilience or...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289514000150 |
| _version_ | 1818051033640730624 |
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| author | Akanksha Singh-Taylor Aniko Korosi Jenny Molet Benjamin G. Gunn Tallie Z. Baram |
| author_facet | Akanksha Singh-Taylor Aniko Korosi Jenny Molet Benjamin G. Gunn Tallie Z. Baram |
| author_sort | Akanksha Singh-Taylor |
| collection | DOAJ |
| description | Genes and environment interact to influence cognitive and emotional functions throughout life. Early-life experiences in particular contribute to vulnerability or resilience to a number of emotional and cognitive illnesses in humans. In rodents, early-life experiences directly lead to resilience or vulnerability to stress later in life, and influence the development of cognitive and emotional deficits. The mechanisms for the enduring effects of early-life experiences on cognitive and emotional outcomes are not completely understood. Here, we present emerging information supporting experience-dependent modulation of the number and efficacy of synaptic inputs onto stress-sensitive neurons. This synaptic ‘rewiring’, in turn, may influence the expression of crucial neuronal genes. The persistent changes in gene expression in resilient versus vulnerable rodent models are likely maintained via epigenetic mechanisms. Thus, early-life experience may generate resilience by altering synaptic input to neurons, which informs them to modulate their epigenetic machinery. |
| first_indexed | 2024-12-10T11:02:56Z |
| format | Article |
| id | doaj.art-d2e80e7cab6147aca738395d107091c3 |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-12-10T11:02:56Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-d2e80e7cab6147aca738395d107091c32022-12-22T01:51:39ZengElsevierNeurobiology of Stress2352-28952015-01-011C10911510.1016/j.ynstr.2014.10.007Synaptic rewiring of stress-sensitive neurons by early-life experience: A mechanism for resilience?Akanksha Singh-Taylor0Aniko Korosi1Jenny Molet2Benjamin G. Gunn3Tallie Z. Baram4Department of Pediatrics, University of California-Irvine, Irvine, CA 92697-4475, USASwammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The NetherlandsDepartment of Anatomy/Neurobiology, University of California-Irvine, Irvine, CA 92697-4475, USADepartment of Pediatrics, University of California-Irvine, Irvine, CA 92697-4475, USADepartment of Pediatrics, University of California-Irvine, Irvine, CA 92697-4475, USAGenes and environment interact to influence cognitive and emotional functions throughout life. Early-life experiences in particular contribute to vulnerability or resilience to a number of emotional and cognitive illnesses in humans. In rodents, early-life experiences directly lead to resilience or vulnerability to stress later in life, and influence the development of cognitive and emotional deficits. The mechanisms for the enduring effects of early-life experiences on cognitive and emotional outcomes are not completely understood. Here, we present emerging information supporting experience-dependent modulation of the number and efficacy of synaptic inputs onto stress-sensitive neurons. This synaptic ‘rewiring’, in turn, may influence the expression of crucial neuronal genes. The persistent changes in gene expression in resilient versus vulnerable rodent models are likely maintained via epigenetic mechanisms. Thus, early-life experience may generate resilience by altering synaptic input to neurons, which informs them to modulate their epigenetic machinery.http://www.sciencedirect.com/science/article/pii/S2352289514000150Synaptic plasticityResilienceStressCorticotropin releasing hormone (CRH)Maternal careEpigenetics |
| spellingShingle | Akanksha Singh-Taylor Aniko Korosi Jenny Molet Benjamin G. Gunn Tallie Z. Baram Synaptic rewiring of stress-sensitive neurons by early-life experience: A mechanism for resilience? Neurobiology of Stress Synaptic plasticity Resilience Stress Corticotropin releasing hormone (CRH) Maternal care Epigenetics |
| title | Synaptic rewiring of stress-sensitive neurons by early-life experience: A mechanism for resilience? |
| title_full | Synaptic rewiring of stress-sensitive neurons by early-life experience: A mechanism for resilience? |
| title_fullStr | Synaptic rewiring of stress-sensitive neurons by early-life experience: A mechanism for resilience? |
| title_full_unstemmed | Synaptic rewiring of stress-sensitive neurons by early-life experience: A mechanism for resilience? |
| title_short | Synaptic rewiring of stress-sensitive neurons by early-life experience: A mechanism for resilience? |
| title_sort | synaptic rewiring of stress sensitive neurons by early life experience a mechanism for resilience |
| topic | Synaptic plasticity Resilience Stress Corticotropin releasing hormone (CRH) Maternal care Epigenetics |
| url | http://www.sciencedirect.com/science/article/pii/S2352289514000150 |
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