The emerging roles of N6-methyladenosine RNA methylation in human cancers
Abstract N6-methyladenosine (m6A) is the most abundant form of mRNA modification in eukaryotes. It affects various aspects of RNA metabolism, including nuclear export, translation, decay and alternative splicing. In addition, m6A also participates in a great number of human physiological processes,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40364-020-00203-6 |
| _version_ | 1819276465065164800 |
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| author | Huafei Shen Yifen Lan Yanchun Zhao Yuanfei Shi Jie Jin Wanzhuo Xie |
| author_facet | Huafei Shen Yifen Lan Yanchun Zhao Yuanfei Shi Jie Jin Wanzhuo Xie |
| author_sort | Huafei Shen |
| collection | DOAJ |
| description | Abstract N6-methyladenosine (m6A) is the most abundant form of mRNA modification in eukaryotes. It affects various aspects of RNA metabolism, including nuclear export, translation, decay and alternative splicing. In addition, m6A also participates in a great number of human physiological processes, ranging from spermatogenesis modulation, response to heat shock, the control of T cell homeostasis to stem cell proliferation and differentiation. The dynamic equilibrium of m6A level is regulated by m6A methyltransferases (“writers”), m6A demethylases (“erasers”) as well as m6A-binding proteins (“readers”). Once the balance is broken, numerous diseases will knock on the door. Recently, increasing studies reveal that m6A methylation exerts a profound impact on tumorigenesis and tumor progression. Therefore, in this review, we summarize the functions of m6A modification and its emerging roles in human cancers, and discuss the potential of m6A regulators as biomarkers or therapeutic targets. |
| first_indexed | 2024-12-23T23:40:39Z |
| format | Article |
| id | doaj.art-d2e8dbab3cc04f5bb49af0359bc3c9ab |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-12-23T23:40:39Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-d2e8dbab3cc04f5bb49af0359bc3c9ab2022-12-21T17:25:40ZengBMCBiomarker Research2050-77712020-06-018111610.1186/s40364-020-00203-6The emerging roles of N6-methyladenosine RNA methylation in human cancersHuafei Shen0Yifen Lan1Yanchun Zhao2Yuanfei Shi3Jie Jin4Wanzhuo Xie5Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang UniversityDepartment of Hematology, the First Affiliated Hospital of Medical School of Zhejiang UniversityDepartment of Hematology, the First Affiliated Hospital of Medical School of Zhejiang UniversityDepartment of Hematology, the First Affiliated Hospital of Medical School of Zhejiang UniversityDepartment of Hematology, the First Affiliated Hospital of Medical School of Zhejiang UniversityDepartment of Hematology, the First Affiliated Hospital of Medical School of Zhejiang UniversityAbstract N6-methyladenosine (m6A) is the most abundant form of mRNA modification in eukaryotes. It affects various aspects of RNA metabolism, including nuclear export, translation, decay and alternative splicing. In addition, m6A also participates in a great number of human physiological processes, ranging from spermatogenesis modulation, response to heat shock, the control of T cell homeostasis to stem cell proliferation and differentiation. The dynamic equilibrium of m6A level is regulated by m6A methyltransferases (“writers”), m6A demethylases (“erasers”) as well as m6A-binding proteins (“readers”). Once the balance is broken, numerous diseases will knock on the door. Recently, increasing studies reveal that m6A methylation exerts a profound impact on tumorigenesis and tumor progression. Therefore, in this review, we summarize the functions of m6A modification and its emerging roles in human cancers, and discuss the potential of m6A regulators as biomarkers or therapeutic targets.http://link.springer.com/article/10.1186/s40364-020-00203-6N6-methyladenosineRNA methylationTumorigenesisCancerEpigeneticsTherapy |
| spellingShingle | Huafei Shen Yifen Lan Yanchun Zhao Yuanfei Shi Jie Jin Wanzhuo Xie The emerging roles of N6-methyladenosine RNA methylation in human cancers Biomarker Research N6-methyladenosine RNA methylation Tumorigenesis Cancer Epigenetics Therapy |
| title | The emerging roles of N6-methyladenosine RNA methylation in human cancers |
| title_full | The emerging roles of N6-methyladenosine RNA methylation in human cancers |
| title_fullStr | The emerging roles of N6-methyladenosine RNA methylation in human cancers |
| title_full_unstemmed | The emerging roles of N6-methyladenosine RNA methylation in human cancers |
| title_short | The emerging roles of N6-methyladenosine RNA methylation in human cancers |
| title_sort | emerging roles of n6 methyladenosine rna methylation in human cancers |
| topic | N6-methyladenosine RNA methylation Tumorigenesis Cancer Epigenetics Therapy |
| url | http://link.springer.com/article/10.1186/s40364-020-00203-6 |
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