Ocular manifestations of psoriasis: An inflammatory disease beyond the skin
Abstract Background Psoriasis is a chronic inflammatory disorder, mainly involves skin. Aims To evaluate the prevalence of ocular manifestations in Iranian patients with psoriasis, compared to healthy controls. Materials and methods Forty psoriasis patients and 40 age‐ and gender‐matched healthy con...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of General and Family Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jgf2.576 |
| _version_ | 1797964563887423488 |
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| author | Zeinab Aryanian Azar Shirzadian Parvaneh Hatami Gholam abbas Roostayi Sadrollah Najafi Azadeh Goodarzi |
| author_facet | Zeinab Aryanian Azar Shirzadian Parvaneh Hatami Gholam abbas Roostayi Sadrollah Najafi Azadeh Goodarzi |
| author_sort | Zeinab Aryanian |
| collection | DOAJ |
| description | Abstract Background Psoriasis is a chronic inflammatory disorder, mainly involves skin. Aims To evaluate the prevalence of ocular manifestations in Iranian patients with psoriasis, compared to healthy controls. Materials and methods Forty psoriasis patients and 40 age‐ and gender‐matched healthy controls were enrolled in the study and underwent a comprehensive ophthalmologic assessment. Results Only meibomian gland dysfunction was significantly more common among patients with psoriasis, compared to control group (p value: 0.011). Regarding intraocular pressure (IOP), the mean values for both patients and healthy controls were within the normal range and mean IOP in patients was even lower than normal controls, although this difference was significant only for left eye (p value: 0.049). A strong positive correlation between PASI and tear meniscus height for both right and left eyes (p value: 0.005, r: 0.44 for OD and p value: 0.003, r: 0.46 for OS.) was noted. Meibomian gland dysfunction was also positively correlated with disease duration for right and left palpebras (p: 0.04, r: 0.31 for both). Conclusion Psoriasis can lead to meibomian gland dysfunction, especially in patients with long‐lasting disease. Hence, dermatologists and general practitioners should be vigilant in this regard when visiting psoriasis patients, especially those who have higher PASI values or long‐lasting disease. |
| first_indexed | 2024-04-11T01:45:57Z |
| format | Article |
| id | doaj.art-d2e96eddbf5d4b77a41adb8acafbe2af |
| institution | Directory Open Access Journal |
| issn | 2189-7948 |
| language | English |
| last_indexed | 2024-04-11T01:45:57Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of General and Family Medicine |
| spelling | doaj.art-d2e96eddbf5d4b77a41adb8acafbe2af2023-01-03T07:37:16ZengWileyJournal of General and Family Medicine2189-79482023-01-01241454910.1002/jgf2.576Ocular manifestations of psoriasis: An inflammatory disease beyond the skinZeinab Aryanian0Azar Shirzadian1Parvaneh Hatami2Gholam abbas Roostayi3Sadrollah Najafi4Azadeh Goodarzi5Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences Tehran IranDepartment of Dermatology Babol University of Medical Sciences Babol IranAutoimmune Bullous Diseases Research Center Tehran University of Medical Sciences Tehran IranDepartment of Ophthalmology Babol University of Medical Sciences Babol IranStudent Research Committee Babol University of Medical Sciences Babol IranDepartment of Dermatology, School of Medicine, Rasool Akram Medical Complex Clinical Research Development Center Iran University of Medical Sciences Tehran IranAbstract Background Psoriasis is a chronic inflammatory disorder, mainly involves skin. Aims To evaluate the prevalence of ocular manifestations in Iranian patients with psoriasis, compared to healthy controls. Materials and methods Forty psoriasis patients and 40 age‐ and gender‐matched healthy controls were enrolled in the study and underwent a comprehensive ophthalmologic assessment. Results Only meibomian gland dysfunction was significantly more common among patients with psoriasis, compared to control group (p value: 0.011). Regarding intraocular pressure (IOP), the mean values for both patients and healthy controls were within the normal range and mean IOP in patients was even lower than normal controls, although this difference was significant only for left eye (p value: 0.049). A strong positive correlation between PASI and tear meniscus height for both right and left eyes (p value: 0.005, r: 0.44 for OD and p value: 0.003, r: 0.46 for OS.) was noted. Meibomian gland dysfunction was also positively correlated with disease duration for right and left palpebras (p: 0.04, r: 0.31 for both). Conclusion Psoriasis can lead to meibomian gland dysfunction, especially in patients with long‐lasting disease. Hence, dermatologists and general practitioners should be vigilant in this regard when visiting psoriasis patients, especially those who have higher PASI values or long‐lasting disease.https://doi.org/10.1002/jgf2.576dry eye syndromemeibomian gland dysfunctionocular manifestationpsoriasispsoriasis area severity index |
| spellingShingle | Zeinab Aryanian Azar Shirzadian Parvaneh Hatami Gholam abbas Roostayi Sadrollah Najafi Azadeh Goodarzi Ocular manifestations of psoriasis: An inflammatory disease beyond the skin Journal of General and Family Medicine dry eye syndrome meibomian gland dysfunction ocular manifestation psoriasis psoriasis area severity index |
| title | Ocular manifestations of psoriasis: An inflammatory disease beyond the skin |
| title_full | Ocular manifestations of psoriasis: An inflammatory disease beyond the skin |
| title_fullStr | Ocular manifestations of psoriasis: An inflammatory disease beyond the skin |
| title_full_unstemmed | Ocular manifestations of psoriasis: An inflammatory disease beyond the skin |
| title_short | Ocular manifestations of psoriasis: An inflammatory disease beyond the skin |
| title_sort | ocular manifestations of psoriasis an inflammatory disease beyond the skin |
| topic | dry eye syndrome meibomian gland dysfunction ocular manifestation psoriasis psoriasis area severity index |
| url | https://doi.org/10.1002/jgf2.576 |
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