Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
The molecular signals regulating the decision of neural stem cells (NSC) to proliferate versus differentiate are unclear. Here, the authors identify the nuclear receptor NR5A2 as coordinating cell-cycle exit with differentiation of NSCs via direct actions on Ink4, Prox1, Notch1 and JAK/STAT.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12230 |
| _version_ | 1818405361833476096 |
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| author | Athanasios Stergiopoulos Panagiotis K. Politis |
| author_facet | Athanasios Stergiopoulos Panagiotis K. Politis |
| author_sort | Athanasios Stergiopoulos |
| collection | DOAJ |
| description | The molecular signals regulating the decision of neural stem cells (NSC) to proliferate versus differentiate are unclear. Here, the authors identify the nuclear receptor NR5A2 as coordinating cell-cycle exit with differentiation of NSCs via direct actions on Ink4, Prox1, Notch1 and JAK/STAT. |
| first_indexed | 2024-12-14T08:54:50Z |
| format | Article |
| id | doaj.art-d2ea2f8f4bcf413f89c3f2c566fc5f26 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:54:50Z |
| publishDate | 2016-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d2ea2f8f4bcf413f89c3f2c566fc5f262022-12-21T23:08:57ZengNature PortfolioNature Communications2041-17232016-07-017111610.1038/ncomms12230Nuclear receptor NR5A2 controls neural stem cell fate decisions during developmentAthanasios Stergiopoulos0Panagiotis K. Politis1Center for Basic Research, Biomedical Research Foundation of the Academy of AthensCenter for Basic Research, Biomedical Research Foundation of the Academy of AthensThe molecular signals regulating the decision of neural stem cells (NSC) to proliferate versus differentiate are unclear. Here, the authors identify the nuclear receptor NR5A2 as coordinating cell-cycle exit with differentiation of NSCs via direct actions on Ink4, Prox1, Notch1 and JAK/STAT.https://doi.org/10.1038/ncomms12230 |
| spellingShingle | Athanasios Stergiopoulos Panagiotis K. Politis Nuclear receptor NR5A2 controls neural stem cell fate decisions during development Nature Communications |
| title | Nuclear receptor NR5A2 controls neural stem cell fate decisions during development |
| title_full | Nuclear receptor NR5A2 controls neural stem cell fate decisions during development |
| title_fullStr | Nuclear receptor NR5A2 controls neural stem cell fate decisions during development |
| title_full_unstemmed | Nuclear receptor NR5A2 controls neural stem cell fate decisions during development |
| title_short | Nuclear receptor NR5A2 controls neural stem cell fate decisions during development |
| title_sort | nuclear receptor nr5a2 controls neural stem cell fate decisions during development |
| url | https://doi.org/10.1038/ncomms12230 |
| work_keys_str_mv | AT athanasiosstergiopoulos nuclearreceptornr5a2controlsneuralstemcellfatedecisionsduringdevelopment AT panagiotiskpolitis nuclearreceptornr5a2controlsneuralstemcellfatedecisionsduringdevelopment |