Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen Planus
Lichen planus is a chronic inflammatory mucocutaneous disease that belongs to the group of papulosquamous skin diseases among diseases like psoriasis, a widely studied disease in dermatology. The aim of the study was to identify the changes between the blood sera of lichen planus patients and health...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/91 |
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| author | Liis Ilves Aigar Ottas Liisi Raam Mihkel Zilmer Tanel Traks Viljar Jaks Külli Kingo |
| author_facet | Liis Ilves Aigar Ottas Liisi Raam Mihkel Zilmer Tanel Traks Viljar Jaks Külli Kingo |
| author_sort | Liis Ilves |
| collection | DOAJ |
| description | Lichen planus is a chronic inflammatory mucocutaneous disease that belongs to the group of papulosquamous skin diseases among diseases like psoriasis, a widely studied disease in dermatology. The aim of the study was to identify the changes between the blood sera of lichen planus patients and healthy controls to widen the knowledge about the metabolomic aspect of lichen planus and gain a better understanding about the pathophysiology of the disease. We used high-throughput nuclear magnetic resonance (NMR) spectroscopy to measure the levels of blood serum metabolites, lipoproteins and lipoprotein particles. Dyslipidemia has relatively recently been shown to be one of the comorbidities of lichen planus, but the changes in the components of lipoproteins have not been described yet. We found statistically significant changes in the concentrations of 16 markers regarding lipoproteins, which included the components of intermediate-density lipoproteins, low-density lipoproteins and large low-density lipoproteins. We propose that the detected changes may increase the risk for specific comorbidities (e.g., dyslipidemia) and resulting cardiovascular diseases, as the turnover and hepatic uptake of the altered/modified lipoprotein particles are disturbed. |
| first_indexed | 2024-03-09T11:42:54Z |
| format | Article |
| id | doaj.art-d2eb07e6039b42bcbbfd32d6e9aec1e6 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:42:54Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-d2eb07e6039b42bcbbfd32d6e9aec1e62023-11-30T23:28:52ZengMDPI AGMetabolites2218-19892023-01-011319110.3390/metabo13010091Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen PlanusLiis Ilves0Aigar Ottas1Liisi Raam2Mihkel Zilmer3Tanel Traks4Viljar Jaks5Külli Kingo6Department of Dermatology and Venereology, University of Tartu, 50417 Tartu, EstoniaDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, EstoniaDepartment of Dermatology and Venereology, University of Tartu, 50417 Tartu, EstoniaDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, EstoniaDepartment of Dermatology and Venereology, University of Tartu, 50417 Tartu, EstoniaDermatology Clinic, Tartu University Hospital, 50417 Tartu, EstoniaDepartment of Dermatology and Venereology, University of Tartu, 50417 Tartu, EstoniaLichen planus is a chronic inflammatory mucocutaneous disease that belongs to the group of papulosquamous skin diseases among diseases like psoriasis, a widely studied disease in dermatology. The aim of the study was to identify the changes between the blood sera of lichen planus patients and healthy controls to widen the knowledge about the metabolomic aspect of lichen planus and gain a better understanding about the pathophysiology of the disease. We used high-throughput nuclear magnetic resonance (NMR) spectroscopy to measure the levels of blood serum metabolites, lipoproteins and lipoprotein particles. Dyslipidemia has relatively recently been shown to be one of the comorbidities of lichen planus, but the changes in the components of lipoproteins have not been described yet. We found statistically significant changes in the concentrations of 16 markers regarding lipoproteins, which included the components of intermediate-density lipoproteins, low-density lipoproteins and large low-density lipoproteins. We propose that the detected changes may increase the risk for specific comorbidities (e.g., dyslipidemia) and resulting cardiovascular diseases, as the turnover and hepatic uptake of the altered/modified lipoprotein particles are disturbed.https://www.mdpi.com/2218-1989/13/1/91lichen planusdermatologylipids |
| spellingShingle | Liis Ilves Aigar Ottas Liisi Raam Mihkel Zilmer Tanel Traks Viljar Jaks Külli Kingo Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen Planus Metabolites lichen planus dermatology lipids |
| title | Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen Planus |
| title_full | Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen Planus |
| title_fullStr | Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen Planus |
| title_full_unstemmed | Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen Planus |
| title_short | Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen Planus |
| title_sort | changes in lipoprotein particles in the blood serum of patients with lichen planus |
| topic | lichen planus dermatology lipids |
| url | https://www.mdpi.com/2218-1989/13/1/91 |
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