Cortical Thickness in Alcohol Dependent Patients With Apathy
ObjectivesMany studies reported structural brain changes in patients with alcohol dependence (PADs). However, no studies identified structural correlates of apathy that might aggravate alcohol misuse. Here, we explored regional differences in cortical thickness in PADs relative to healthy controls (...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00364/full |
| _version_ | 1818385070978760704 |
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| author | Kebing Yang Qingyan Yang Yajuan Niu Fengmei Fan Song Chen Xingguang Luo Shuping Tan Zhiren Wang Jinghui Tong Fude Yang Thang M. Le Chiang-Shan R. Li Chiang-Shan R. Li Yunlong Tan |
| author_facet | Kebing Yang Qingyan Yang Yajuan Niu Fengmei Fan Song Chen Xingguang Luo Shuping Tan Zhiren Wang Jinghui Tong Fude Yang Thang M. Le Chiang-Shan R. Li Chiang-Shan R. Li Yunlong Tan |
| author_sort | Kebing Yang |
| collection | DOAJ |
| description | ObjectivesMany studies reported structural brain changes in patients with alcohol dependence (PADs). However, no studies identified structural correlates of apathy that might aggravate alcohol misuse. Here, we explored regional differences in cortical thickness in PADs relative to healthy controls (HCs), and examined the potential correlation of regional thickness with the severity of apathy.MethodsMagnetic resonance imaging data were collected from 33 male PADs and 35 male age- and education-matched HCs. We used the FreeSurfer software to investigate group differences in cortical thickness across 148 regions. Apathy was evaluated using the Lille Apathy Rating Scale-Informant (LARS-I). Regression analyses examined the relationship between cortical thickness of regions of interest and apathy score in PADs.ResultsCompared to HCs, PADs showed significant decreases in the cortical thickness of occipito-temporal cortex (OTC), including the left middle occipital gyrus and occipital pole, right superior occipital gyri, and bilateral lingual gyrus; bilateral superior parietal cortex (SPC), including the right intraparietal sulcus; and bilateral inferior parietal cortex (IPC). Furthermore, the cortical thickness of all of the three regions was negatively correlated with the apathy total scores. The cortical thickness of the IPC was also negatively correlated with the action initiation subscore of the LARS-I.ConclusionsThe current results suggest the thickness of bilateral parietal and occipital temporal cortices as neural markers of apathy in PADs. These findings add to the literature by identifying the neural bases of a critical clinical feature of individuals with alcoholism. |
| first_indexed | 2024-12-14T03:32:19Z |
| format | Article |
| id | doaj.art-d2ecce535e5542958129354c95720c7b |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-14T03:32:19Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d2ecce535e5542958129354c95720c7b2022-12-21T23:18:43ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-05-011110.3389/fpsyt.2020.00364537709Cortical Thickness in Alcohol Dependent Patients With ApathyKebing Yang0Qingyan Yang1Yajuan Niu2Fengmei Fan3Song Chen4Xingguang Luo5Shuping Tan6Zhiren Wang7Jinghui Tong8Fude Yang9Thang M. Le10Chiang-Shan R. Li11Chiang-Shan R. Li12Yunlong Tan13Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United StatesPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, United StatesPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, ChinaObjectivesMany studies reported structural brain changes in patients with alcohol dependence (PADs). However, no studies identified structural correlates of apathy that might aggravate alcohol misuse. Here, we explored regional differences in cortical thickness in PADs relative to healthy controls (HCs), and examined the potential correlation of regional thickness with the severity of apathy.MethodsMagnetic resonance imaging data were collected from 33 male PADs and 35 male age- and education-matched HCs. We used the FreeSurfer software to investigate group differences in cortical thickness across 148 regions. Apathy was evaluated using the Lille Apathy Rating Scale-Informant (LARS-I). Regression analyses examined the relationship between cortical thickness of regions of interest and apathy score in PADs.ResultsCompared to HCs, PADs showed significant decreases in the cortical thickness of occipito-temporal cortex (OTC), including the left middle occipital gyrus and occipital pole, right superior occipital gyri, and bilateral lingual gyrus; bilateral superior parietal cortex (SPC), including the right intraparietal sulcus; and bilateral inferior parietal cortex (IPC). Furthermore, the cortical thickness of all of the three regions was negatively correlated with the apathy total scores. The cortical thickness of the IPC was also negatively correlated with the action initiation subscore of the LARS-I.ConclusionsThe current results suggest the thickness of bilateral parietal and occipital temporal cortices as neural markers of apathy in PADs. These findings add to the literature by identifying the neural bases of a critical clinical feature of individuals with alcoholism.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00364/fullalcohol dependenceapathyoccipito-temporal cortexsuperior parietal cortexinferior parietal cortex |
| spellingShingle | Kebing Yang Qingyan Yang Yajuan Niu Fengmei Fan Song Chen Xingguang Luo Shuping Tan Zhiren Wang Jinghui Tong Fude Yang Thang M. Le Chiang-Shan R. Li Chiang-Shan R. Li Yunlong Tan Cortical Thickness in Alcohol Dependent Patients With Apathy Frontiers in Psychiatry alcohol dependence apathy occipito-temporal cortex superior parietal cortex inferior parietal cortex |
| title | Cortical Thickness in Alcohol Dependent Patients With Apathy |
| title_full | Cortical Thickness in Alcohol Dependent Patients With Apathy |
| title_fullStr | Cortical Thickness in Alcohol Dependent Patients With Apathy |
| title_full_unstemmed | Cortical Thickness in Alcohol Dependent Patients With Apathy |
| title_short | Cortical Thickness in Alcohol Dependent Patients With Apathy |
| title_sort | cortical thickness in alcohol dependent patients with apathy |
| topic | alcohol dependence apathy occipito-temporal cortex superior parietal cortex inferior parietal cortex |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00364/full |
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