A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus
BackgroundPrevious studies have reported an association between sarcopenia and type 2 diabetes mellitus (T2DM), but causation was prone to confounding factors. A more robust research approach is urgently required to investigate the causal relationship between sarcopenia and T2DM.MethodsThe bi-direct...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1109800/full |
| _version_ | 1811158342814400512 |
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| author | Simin Chen Shikang Yan Nuerbiyamu Aiheti Kaidiriyan Kuribanjiang Xuemei Yao Qian Wang Tao Zhou Lei Yang Lei Yang |
| author_facet | Simin Chen Shikang Yan Nuerbiyamu Aiheti Kaidiriyan Kuribanjiang Xuemei Yao Qian Wang Tao Zhou Lei Yang Lei Yang |
| author_sort | Simin Chen |
| collection | DOAJ |
| description | BackgroundPrevious studies have reported an association between sarcopenia and type 2 diabetes mellitus (T2DM), but causation was prone to confounding factors. A more robust research approach is urgently required to investigate the causal relationship between sarcopenia and T2DM.MethodsThe bi-directional two-sample MR study was carried out in two stages: Sarcopenia-related traits were investigated as exposure while T2DM was investigated as an outcome in the first step, whereas the second step was reversed. The GWAS summary data for hand-grip strength (n = 256,523), appendicular lean mass (ALM, n = 450,243), and walking pace (n = 459,915) were obtained from the UK Biobank. T2DM data were obtained from one of the biggest case-control studies on diabetes (DIAGRAM; n = 180,834 cases and 492,191 controls), which was published in 2022. The inverse-variance weighted (IVW) approach was used to obtain MR estimates, and various sensitivity analysis was also performed.ResultsLow hand-grip strength had a potential causal relationship with an increased incidence of T2DM (OR = 1.109; 95% CI, 1.008–1.222; p = 0.0350). T2DM risk was reduced by increasing ALM and walking pace: A 1 kg/m2 increase in ALM decreased the risk of T2DM by 10.2% (OR = 0.898; 95% CI, 0.830–0.952; p < 0.001). A 1 m/s increase in walking pace decreased the risk of T2DM by 90.0% (OR = 0.100; 95% CI, 0.053–0.186; p < 0.001). The relationship was bidirectional, with T2DM as a causative factor of sarcopenia-related traits (p < 0.05) except for ALM (β = 0.018; 95% CI, −0.008 to −0.044; p = 0.168).ConclusionsHand-grip strength and T2DM had a potential bidirectional causal relationship, as did walking pace and T2DM. We suggest that sarcopenia and T2DM may mutually have a significant causal effect on each other. |
| first_indexed | 2024-04-10T05:22:54Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T05:22:54Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-d2ee85bb72d54506a72270dd38b612fa2023-03-08T06:42:50ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11098001109800A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitusSimin Chen0Shikang Yan1Nuerbiyamu Aiheti2Kaidiriyan Kuribanjiang3Xuemei Yao4Qian Wang5Tao Zhou6Lei Yang7Lei Yang8Department of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, ChinaState Key Laboratory of Causes and Prevention of High Morbidity in Central Asia jointly established by the Ministry and the Province Urumqi, Xinjiang, ChinaBackgroundPrevious studies have reported an association between sarcopenia and type 2 diabetes mellitus (T2DM), but causation was prone to confounding factors. A more robust research approach is urgently required to investigate the causal relationship between sarcopenia and T2DM.MethodsThe bi-directional two-sample MR study was carried out in two stages: Sarcopenia-related traits were investigated as exposure while T2DM was investigated as an outcome in the first step, whereas the second step was reversed. The GWAS summary data for hand-grip strength (n = 256,523), appendicular lean mass (ALM, n = 450,243), and walking pace (n = 459,915) were obtained from the UK Biobank. T2DM data were obtained from one of the biggest case-control studies on diabetes (DIAGRAM; n = 180,834 cases and 492,191 controls), which was published in 2022. The inverse-variance weighted (IVW) approach was used to obtain MR estimates, and various sensitivity analysis was also performed.ResultsLow hand-grip strength had a potential causal relationship with an increased incidence of T2DM (OR = 1.109; 95% CI, 1.008–1.222; p = 0.0350). T2DM risk was reduced by increasing ALM and walking pace: A 1 kg/m2 increase in ALM decreased the risk of T2DM by 10.2% (OR = 0.898; 95% CI, 0.830–0.952; p < 0.001). A 1 m/s increase in walking pace decreased the risk of T2DM by 90.0% (OR = 0.100; 95% CI, 0.053–0.186; p < 0.001). The relationship was bidirectional, with T2DM as a causative factor of sarcopenia-related traits (p < 0.05) except for ALM (β = 0.018; 95% CI, −0.008 to −0.044; p = 0.168).ConclusionsHand-grip strength and T2DM had a potential bidirectional causal relationship, as did walking pace and T2DM. We suggest that sarcopenia and T2DM may mutually have a significant causal effect on each other.https://www.frontiersin.org/articles/10.3389/fendo.2023.1109800/fulltype 2 diabetes mellitussarcopeniamendelian randomizationhand-grip strengthappendicular lean masswalking pace |
| spellingShingle | Simin Chen Shikang Yan Nuerbiyamu Aiheti Kaidiriyan Kuribanjiang Xuemei Yao Qian Wang Tao Zhou Lei Yang Lei Yang A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus Frontiers in Endocrinology type 2 diabetes mellitus sarcopenia mendelian randomization hand-grip strength appendicular lean mass walking pace |
| title | A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus |
| title_full | A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus |
| title_fullStr | A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus |
| title_full_unstemmed | A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus |
| title_short | A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus |
| title_sort | bi directional mendelian randomization study of sarcopenia related traits and type 2 diabetes mellitus |
| topic | type 2 diabetes mellitus sarcopenia mendelian randomization hand-grip strength appendicular lean mass walking pace |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1109800/full |
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