Treatment of Painful Diabetic Neuropathy—A Narrative Review of Pharmacological and Interventional Approaches
Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus that is associated with a significant decline in quality of life. Like other painful neuropathic conditions, PDN is difficult to manage clinically, and a variety of pharmacological and non-pharmacological options are ava...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/5/573 |
| _version_ | 1797533575438925824 |
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| author | Mayank Gupta Nebojsa Nick Knezevic Alaa Abd-Elsayed Mahoua Ray Kiran Patel Bhavika Chowdhury |
| author_facet | Mayank Gupta Nebojsa Nick Knezevic Alaa Abd-Elsayed Mahoua Ray Kiran Patel Bhavika Chowdhury |
| author_sort | Mayank Gupta |
| collection | DOAJ |
| description | Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus that is associated with a significant decline in quality of life. Like other painful neuropathic conditions, PDN is difficult to manage clinically, and a variety of pharmacological and non-pharmacological options are available for this condition. Recommended pharmacotherapies include anticonvulsive agents, antidepressant drugs, and topical capsaicin; and tapentadol, which combines opioid agonism and norepinephrine reuptake inhibition, has also recently been approved for use. Additionally, several neuromodulation therapies have been successfully used for pain relief in PDN, including intrathecal therapy, transcutaneous electrical nerve stimulation (TENS), and spinal cord stimulation (SCS). Recently, 10 kHz SCS has been shown to provide clinically meaningful pain relief for patients refractory to conventional medical management, with a subset of patients demonstrating improvement in neurological function. This literature review is intended to discuss the dosage and prospective data associated with pain management therapies for PDN. |
| first_indexed | 2024-03-10T11:16:33Z |
| format | Article |
| id | doaj.art-d2f04a8f65814f5ca51f48d531e57303 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T11:16:33Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-d2f04a8f65814f5ca51f48d531e573032023-11-21T20:24:14ZengMDPI AGBiomedicines2227-90592021-05-019557310.3390/biomedicines9050573Treatment of Painful Diabetic Neuropathy—A Narrative Review of Pharmacological and Interventional ApproachesMayank Gupta0Nebojsa Nick Knezevic1Alaa Abd-Elsayed2Mahoua Ray3Kiran Patel4Bhavika Chowdhury5Kansas Pain Management & Neuroscience Research Center, Overland Park, KS 66201, USADepartment of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USADepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53715, USAKansas Pain Management & Neuroscience Research Center, Overland Park, KS 66201, USADepartment of Pain Management, Spine and Pain Institute of New York, New York, NY 10065, USADepartment of Endocrinology, Saint Luke’s South Hospital, Overland Park, KS 66213, USAPainful diabetic neuropathy (PDN) is a common complication of diabetes mellitus that is associated with a significant decline in quality of life. Like other painful neuropathic conditions, PDN is difficult to manage clinically, and a variety of pharmacological and non-pharmacological options are available for this condition. Recommended pharmacotherapies include anticonvulsive agents, antidepressant drugs, and topical capsaicin; and tapentadol, which combines opioid agonism and norepinephrine reuptake inhibition, has also recently been approved for use. Additionally, several neuromodulation therapies have been successfully used for pain relief in PDN, including intrathecal therapy, transcutaneous electrical nerve stimulation (TENS), and spinal cord stimulation (SCS). Recently, 10 kHz SCS has been shown to provide clinically meaningful pain relief for patients refractory to conventional medical management, with a subset of patients demonstrating improvement in neurological function. This literature review is intended to discuss the dosage and prospective data associated with pain management therapies for PDN.https://www.mdpi.com/2227-9059/9/5/573painful diabetic neuropathydiabetesneuropathic painperipheral diabetic neuropathyneuromodulation10 kHz SCS |
| spellingShingle | Mayank Gupta Nebojsa Nick Knezevic Alaa Abd-Elsayed Mahoua Ray Kiran Patel Bhavika Chowdhury Treatment of Painful Diabetic Neuropathy—A Narrative Review of Pharmacological and Interventional Approaches Biomedicines painful diabetic neuropathy diabetes neuropathic pain peripheral diabetic neuropathy neuromodulation 10 kHz SCS |
| title | Treatment of Painful Diabetic Neuropathy—A Narrative Review of Pharmacological and Interventional Approaches |
| title_full | Treatment of Painful Diabetic Neuropathy—A Narrative Review of Pharmacological and Interventional Approaches |
| title_fullStr | Treatment of Painful Diabetic Neuropathy—A Narrative Review of Pharmacological and Interventional Approaches |
| title_full_unstemmed | Treatment of Painful Diabetic Neuropathy—A Narrative Review of Pharmacological and Interventional Approaches |
| title_short | Treatment of Painful Diabetic Neuropathy—A Narrative Review of Pharmacological and Interventional Approaches |
| title_sort | treatment of painful diabetic neuropathy a narrative review of pharmacological and interventional approaches |
| topic | painful diabetic neuropathy diabetes neuropathic pain peripheral diabetic neuropathy neuromodulation 10 kHz SCS |
| url | https://www.mdpi.com/2227-9059/9/5/573 |
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