Variations of the UNC13D gene in patients with autoimmune lymphoproliferative syndrome.

Variations of the UNC13D gene in patients with autoimmune lymphoproliferative syndrome.

Autoimmune lymphoproliferative syndrome (ALPS) is caused by genetic defects decreasing Fas function and is characterized by lymphadenopathy/splenomegaly and expansion of CD4/CD8 double-negative T cells. This latter expansion is absent in the ALPS variant named Dianzani Autoimmune/lymphoproliferative...

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Main Authors: Maurizio Aricò, Elena Boggio, Valentina Cetica, Matteo Melensi, Elisabetta Orilieri, Nausicaa Clemente, Giuseppe Cappellano, Sara Buttini, Maria Felicia Soluri, Cristoforo Comi, Carlo Dufour, Daniela Pende, Irma Dianzani, Steven R Ellis, Sara Pagliano, Stefania Marcenaro, Ugo Ramenghi, Annalisa Chiocchetti, Umberto Dianzani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3698121?pdf=render

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