Lipid Signaling During Gamete Maturation
Cell lipids are differentially distributed in distinct organelles and within the leaflets of the bilayer. They can further form laterally defined sub-domains within membranes with important signaling functions. This molecular and spatial complexity offers optimal platforms for signaling with the ass...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.814876/full |
| _version_ | 1798035732839792640 |
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| author | Sherif Mostafa Nancy Nader Nancy Nader Khaled Machaca Khaled Machaca |
| author_facet | Sherif Mostafa Nancy Nader Nancy Nader Khaled Machaca Khaled Machaca |
| author_sort | Sherif Mostafa |
| collection | DOAJ |
| description | Cell lipids are differentially distributed in distinct organelles and within the leaflets of the bilayer. They can further form laterally defined sub-domains within membranes with important signaling functions. This molecular and spatial complexity offers optimal platforms for signaling with the associated challenge of dissecting these pathways especially that lipid metabolism tends to be highly interconnected. Lipid signaling has historically been implicated in gamete function, however the detailed signaling pathways involved remain obscure. In this review we focus on oocyte and sperm maturation in an effort to consolidate current knowledge of the role of lipid signaling and set the stage for future directions. |
| first_indexed | 2024-04-11T21:02:21Z |
| format | Article |
| id | doaj.art-d2f23cdce1944c93b5e3ed0a3b91a92c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T21:02:21Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d2f23cdce1944c93b5e3ed0a3b91a92c2022-12-22T04:03:28ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-06-011010.3389/fcell.2022.814876814876Lipid Signaling During Gamete MaturationSherif Mostafa0Nancy Nader1Nancy Nader2Khaled Machaca3Khaled Machaca4Medical Program, WCMQ, Education City, Qatar Foundation, Doha, QatarCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar (WCMQ), Education City, Qatar Foundation, Doha, QatarDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United StatesCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar (WCMQ), Education City, Qatar Foundation, Doha, QatarDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United StatesCell lipids are differentially distributed in distinct organelles and within the leaflets of the bilayer. They can further form laterally defined sub-domains within membranes with important signaling functions. This molecular and spatial complexity offers optimal platforms for signaling with the associated challenge of dissecting these pathways especially that lipid metabolism tends to be highly interconnected. Lipid signaling has historically been implicated in gamete function, however the detailed signaling pathways involved remain obscure. In this review we focus on oocyte and sperm maturation in an effort to consolidate current knowledge of the role of lipid signaling and set the stage for future directions.https://www.frontiersin.org/articles/10.3389/fcell.2022.814876/fulloocyteeggspermglycerolphospholipidsphingolipidceramides |
| spellingShingle | Sherif Mostafa Nancy Nader Nancy Nader Khaled Machaca Khaled Machaca Lipid Signaling During Gamete Maturation Frontiers in Cell and Developmental Biology oocyte egg sperm glycerolphospholipid sphingolipid ceramides |
| title | Lipid Signaling During Gamete Maturation |
| title_full | Lipid Signaling During Gamete Maturation |
| title_fullStr | Lipid Signaling During Gamete Maturation |
| title_full_unstemmed | Lipid Signaling During Gamete Maturation |
| title_short | Lipid Signaling During Gamete Maturation |
| title_sort | lipid signaling during gamete maturation |
| topic | oocyte egg sperm glycerolphospholipid sphingolipid ceramides |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.814876/full |
| work_keys_str_mv | AT sherifmostafa lipidsignalingduringgametematuration AT nancynader lipidsignalingduringgametematuration AT nancynader lipidsignalingduringgametematuration AT khaledmachaca lipidsignalingduringgametematuration AT khaledmachaca lipidsignalingduringgametematuration |