Mesenchymal stem cells combined with autocrosslinked hyaluronic acid improve mouse ovarian function by activating the PI3K-AKT pathway in a paracrine manner

Mesenchymal stem cells combined with autocrosslinked hyaluronic acid improve mouse ovarian function by activating the PI3K-AKT pathway in a paracrine manner

Abstract Background Declining ovarian function in advance-aged women and in premature ovarian insufficiency (POI) patients seriously affects quality of life, and there is currently no effective treatment to rescue ovarian function in clinic. Stem cell transplantation is a promising therapeutic strat...

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Bibliographic Details
Main Authors: Wenlin Jiao, Xin Mi, Yajuan Yang, Ran Liu, Qiang Liu, Tao Yan, Zi-Jiang Chen, Yingying Qin, Shidou Zhao
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Hyaluronic acid
Paracrine
PI3K-AKT pathway
Premature ovarian insufficiency
Ovarian aging
Online Access:https://doi.org/10.1186/s13287-022-02724-3

Internet

https://doi.org/10.1186/s13287-022-02724-3

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