Harnessing digital health to objectively assess cancer-related fatigue: The impact of fatigue on mobility performance.
<h4>Objective</h4>Cancer-related fatigue (CRF) is highly prevalent among cancer survivors, which may have long-term effects on physical activity and quality of life. CRF is assessed by self-report or clinical observation, which may limit timely diagnosis and management. In this study, we...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0246101 |
| _version_ | 1818825195816747008 |
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| author | Yvonne H Sada Olia Poursina He Zhou Biruh T Workeneh Sandhya V Maddali Bijan Najafi |
| author_facet | Yvonne H Sada Olia Poursina He Zhou Biruh T Workeneh Sandhya V Maddali Bijan Najafi |
| author_sort | Yvonne H Sada |
| collection | DOAJ |
| description | <h4>Objective</h4>Cancer-related fatigue (CRF) is highly prevalent among cancer survivors, which may have long-term effects on physical activity and quality of life. CRF is assessed by self-report or clinical observation, which may limit timely diagnosis and management. In this study, we examined the effect of CRF on mobility performance measured by a wearable pendant sensor.<h4>Methods</h4>This is a secondary analysis of a clinical trial evaluating the benefit of exercise in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN). CRF status was classified based on a Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) score ≤ 33. Among 28 patients (age = 65.7±9.8 years old, BMI = 26.9±4.1kg/m2, sex = 32.9%female) with database variables of interest, twenty-one subjects (75.9%) were classified as non-CRF. Mobility performance, including behavior (sedentary, light, and moderate to vigorous activity (MtV)), postures (sitting, standing, lying, and walking), and locomotion (e.g., steps, postural transitions) were measured using a validated pendant-sensor over 24-hours. Baseline psychosocial, Functional Assessment of Cancer Therapy-General (FACT-G), Falls Efficacy Scale-International (FES-I), and motor-capacity assessments including gait (habitual speed, fast speed, and dual-task speed) and static balance were also performed.<h4>Results</h4>Both groups had similar baseline clinical and psychosocial characteristics, except for body-mass index (BMI), FACT-G, FACIT-F, and FES-I (p<0.050). The groups did not differ on motor-capacity. However, the majority of mobility performance parameters were different between groups with large to very large effect size, Cohen's d ranging from 0.91 to 1.59. Among assessed mobility performance, the largest effect sizes were observed for sedentary-behavior (d = 1.59, p = 0.006), light-activity (d = 1.48, p = 0.009), and duration of sitting+lying (d = 1.46, p = 0.016). The largest correlations between mobility performance and FACIT-F were observed for sitting+lying (rho = -0.67, p<0.001) and the number of steps per day (rho = 0.60, p = 0.001).<h4>Conclusion</h4>The results of this study suggest that sensor-based mobility performance monitoring could be considered as a potential digital biomarker for CRF assessment. Future studies warrant evaluating utilization of mobility performance to track changes in CRF over time, response to CRF-related interventions, and earlier detection of CRF. |
| first_indexed | 2024-12-19T00:07:55Z |
| format | Article |
| id | doaj.art-d2f69bf60c3346a888c2c79e2e2963d1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T00:07:55Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-d2f69bf60c3346a888c2c79e2e2963d12022-12-21T20:46:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01162e024610110.1371/journal.pone.0246101Harnessing digital health to objectively assess cancer-related fatigue: The impact of fatigue on mobility performance.Yvonne H SadaOlia PoursinaHe ZhouBiruh T WorkenehSandhya V MaddaliBijan Najafi<h4>Objective</h4>Cancer-related fatigue (CRF) is highly prevalent among cancer survivors, which may have long-term effects on physical activity and quality of life. CRF is assessed by self-report or clinical observation, which may limit timely diagnosis and management. In this study, we examined the effect of CRF on mobility performance measured by a wearable pendant sensor.<h4>Methods</h4>This is a secondary analysis of a clinical trial evaluating the benefit of exercise in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN). CRF status was classified based on a Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) score ≤ 33. Among 28 patients (age = 65.7±9.8 years old, BMI = 26.9±4.1kg/m2, sex = 32.9%female) with database variables of interest, twenty-one subjects (75.9%) were classified as non-CRF. Mobility performance, including behavior (sedentary, light, and moderate to vigorous activity (MtV)), postures (sitting, standing, lying, and walking), and locomotion (e.g., steps, postural transitions) were measured using a validated pendant-sensor over 24-hours. Baseline psychosocial, Functional Assessment of Cancer Therapy-General (FACT-G), Falls Efficacy Scale-International (FES-I), and motor-capacity assessments including gait (habitual speed, fast speed, and dual-task speed) and static balance were also performed.<h4>Results</h4>Both groups had similar baseline clinical and psychosocial characteristics, except for body-mass index (BMI), FACT-G, FACIT-F, and FES-I (p<0.050). The groups did not differ on motor-capacity. However, the majority of mobility performance parameters were different between groups with large to very large effect size, Cohen's d ranging from 0.91 to 1.59. Among assessed mobility performance, the largest effect sizes were observed for sedentary-behavior (d = 1.59, p = 0.006), light-activity (d = 1.48, p = 0.009), and duration of sitting+lying (d = 1.46, p = 0.016). The largest correlations between mobility performance and FACIT-F were observed for sitting+lying (rho = -0.67, p<0.001) and the number of steps per day (rho = 0.60, p = 0.001).<h4>Conclusion</h4>The results of this study suggest that sensor-based mobility performance monitoring could be considered as a potential digital biomarker for CRF assessment. Future studies warrant evaluating utilization of mobility performance to track changes in CRF over time, response to CRF-related interventions, and earlier detection of CRF.https://doi.org/10.1371/journal.pone.0246101 |
| spellingShingle | Yvonne H Sada Olia Poursina He Zhou Biruh T Workeneh Sandhya V Maddali Bijan Najafi Harnessing digital health to objectively assess cancer-related fatigue: The impact of fatigue on mobility performance. PLoS ONE |
| title | Harnessing digital health to objectively assess cancer-related fatigue: The impact of fatigue on mobility performance. |
| title_full | Harnessing digital health to objectively assess cancer-related fatigue: The impact of fatigue on mobility performance. |
| title_fullStr | Harnessing digital health to objectively assess cancer-related fatigue: The impact of fatigue on mobility performance. |
| title_full_unstemmed | Harnessing digital health to objectively assess cancer-related fatigue: The impact of fatigue on mobility performance. |
| title_short | Harnessing digital health to objectively assess cancer-related fatigue: The impact of fatigue on mobility performance. |
| title_sort | harnessing digital health to objectively assess cancer related fatigue the impact of fatigue on mobility performance |
| url | https://doi.org/10.1371/journal.pone.0246101 |
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